What's your tolerance to any of these drug? What doses are you taking? How long have you been taking any of these drugs? All these things are going to effect the answer.
Mixing depressants can kill you, mixing drugs of any kind can kill you. Wanting to stay alive and enjoy some drugs in the future means saying 'no' some times.
Honestly, the combination isn’t going to “kill you” (most likely), but the drugs would be best utilized this way. Opioids and amphs are pleasant together, but having something to come down with works far better IME.