Rectify's molecular poetry thread

[Dresden]

EMINEM ["MARSHALL MATHERS"]

AFAICT, the 2,4-peas/amps are canine in nature, while the 3,4,5's are feline.

 

[adder]

A pretty bad joke,pomzazed, and the really annoying thing is the OP is obviously a liar.

Look at him say he is just starting to learn basic chem, then further back, claimed to be an 'established drug designer' whatever that is. I saw through through it and called him out, to give an explanation of his statements, only to be told to fuck off.

So yes I'm annoyed, because the OP is full of shit and a liar.

Oh, well, he's playing with you now too, he's an established drug designer by this thread alone if you know what I mean. But I get it, I don't condone name calling, it could be out of boredom or whatever, but I do not condone it. If you can, give him some understanding, if I keep track of what's going on here lately, he's got some meth problem, we all know quitting drugs and then facing reality sober is not an easy thing to do. Otherwise if someone's rude to you, just ignore them. IIRC, Dresden pointed out once he finished chemistry so can't be starting basic chem now.

 

[Pomzazed]

[rant] wtf I typed a lot on my ipad then lost connection and all texts are lost; gonna retype all em again! [/rant]

@Dresden
- Keep it coming, some of the molecules are interesting (although most of them are weirdly named without correlation or whatsover), I just like to imagine their 3D shapes

@Limpet_Chicken, @adder
- I don't really mind about Dresden or what he is and is not, as long as the random naming and weird molecules do not spam the main thread, where it supposed to be 'fun'
- Aryl Hydrocarbon Receptor (AHR) is a whore receptor; say; it has very wide variety of ligands that will bind to it.
Basically it is just a sensor for xenochemical aromatics so the body can acknowledge and eliminate them from the body accordingly. Since most of these molecules are highly hydrophobic and tends to be stored in fat cells, so the body must find a way to sense them, and abolish them by activating oxidative pathway (mostly CYP450) to make them more polar so being easier to excrete via urine (or adding more functional group so it can be conjugated with, say, glucoronides then excreted)
- But the bad thing about that is some metabolites are even more toxic and just don't want to exit the body (eg. benzopyrene -> its epoxides), and increasing oxidation means alot of free radical concentration damaging other parts of the cells.
- General requirements are easy: 1.Flat 2.Has conjugated pi-system 3.Larger than benzene (Example of ligands: Naphthalene, Pyrene, Indole)
- Substituents on the plane are possible, lipophilic substituents and halogens increase affinity in comparison to hydrocarbon-only ring (Example: anthraquinone, hexachlorobenzene, indigo, benzoflavones, indirubin, dioxins)
- Large Substituents can be out-of-plane if they are not tightly "fixed" onto the plane (say, not polycyclic nonaromatics attached to aromatic like morphinans or sterols which do not bind) and is approximate 2+ carbon distances from the "main ring", (Example: diphenylmethane). This is also the reason i believe that some cannabimimetic indoles metabolite will also activated this ligand (Example: N-Despentyl-JWH-018 and Dresden's "Alisson")
- Even non aromatic can also bind to this receptor as long as it has similar shape of recognition, like conjugated cis-cis-trans or cis-cis-cis fatty acid detivatives. (Example: Lipoxin - interesting structure: https://en.wikipedia.org/wiki/Lipoxin)

One thing, meeting the requirement does not mean the molecule will bind AHR in vivo, it seems like another requirement is the lack of feasible excretion pathway and being kept inside the cell for so long.

 

[Dresden]

Some points:

1.If you want cannabinoid activity, remove the OH from WAYNE and FLOYD,
Or change it to OMe, or they will be absense of CB1/2 activity.

2.WAYNE is quite unstable to acidic environment, i think even pH5-6 aq. workup will dealkylate the pyrrole.
Maybe the phenolic OH itself is able to autocatalyse this reaction in polar solvent already

3.Both seems to not withstand vaporization tho, if administration is done at all, they seemed to withstand less than 100 C due to the nature of that ?oxalyl? type, prone to degrade to carbon monoxide, idk about your molecules, but similar molecules with this indole,CO,CO,aryl bridge decomposes at like 45C-70C so i had to workup in ice bath. (I was synthesis polyamine coupling agent at the time)

Can we have a thread dedicated to this type of hands on yet still rigorous, quantitative, general and exhaustive chemical information?

I started grad school today. I feel a bit uneasy about it. I'm going for my masters but the professor made it clear that phd programs are where it's at. I just want to make and patent 3 or 4 good, useful compounds and auction off the patent rights. I wonder, do I even need to go to grad school or should I just find a biochemtech company that believes in me?

Limpet_Chicken, I have never made an illegal drug in my life, yet, and I don't know if I ever will or not. (But legally, isn't that on a very real and large way a GOOD thing from my perspective, duh?)

Now, I ain't no spring chicken or a hillbilly. And for your 411, I got syphilis at 11 years old indirectly from Freddy Kreuger, not my mother WHO IS A SAINT. If you've been following all the goings ons of the hive and of bluelight over the last couple o decades, you will know that I am truly a bona fida virtual drug designer of sorts. Or at least I know that. Let's just put it like that. Teamwork: It takes all kinds.

Lastly, if you are interested, I am willing to write up telepathic trip reports for Shiva, Willing Way, and Brooks as long as no flaming breaks out like California wildfires.

 

[Dresden]

CUPPA JOE

WILLIE JOE

CJ is from theobromine which is from chocolate.
WJ is from theophylline which is fron tea leaves
(Rather easily, I would imagine, in both instances.)

CJ is probably a stimulant, but it *could* conceivably be an entactogen. I doubt that latter prognostication.

WJ is probably a tryptamine like hallucinogen when smoked/vaporized or injected. These two gems, both sourced from uncontrollable chocolate or tea derivatives, are almost guaranteed to be active, as their xanthine nucleus is fully aromatic in its own right, just like a benzene or indolyl nucleus. Bon apetit! Literally, Good Ape Tit, Mammals! So what if mammals suck?! I heart being a mammal with my man pec mammaries and voracious oral sucking fixation, lol.) E N J O Y but remember, Sharing Is Caring!!! You'd better bow down on both knees. Who'd you think talk you to smoke weed!

 

[Limpet_Chicken]

Actually I really don't have sufficient regard for one who so inanely takes to insult me, to give enough of a damn to value him to the point of view he could easily insult me; yes, there are words that would result in my killing him on the spot, hut he will never know to/about who, or why. And that would apply to almost anyone, not just him.

As far as I'm concerned, he's just a reference sample of arsenacyclopentadiene held just barely around his melting point with really inefficient heating/cooling point. Haven't the energy to attempt to dimerize him and stick a comma in his middle

(you gotta give me that for a decent comeback, no? it was at least creative)

It was most of all, the fact that he bald-faced lied to us ALL, in saying he was an 'established drug designer' and not long later AT ALL, claimed he was just about entering college to study pharmacology/chemistry or both. BOTH cannot be at the same time, truth, ergo one must be a lie.

And to simply tell me, someone who ACTUALLY knows what they are talking about, in such a forum, well,it is an insult and offense to us all is it not? to openly lie to us like this? it is in my book.

Hell I bet he couldn't make bromethiazole or chlormethiazole if he had the thionyl halide there, the reagent grade very initial substrate, and the thing used to cleave the first starting compound! and thats with instructions! I'm serious, he'd problably poison himself, (hopefully if anyone, ONLY so, and nobody else) because of the pyrimidine byproduct.

Could I do so without that happening? sure! have had to before to avoid having seizures after an obnoxious locum berated me not for coming in too often for my chlormethiazole rescue packs, but said 'oh if you can manage THAT long, you can wait until the doctor I want you to see gets back off holiday'' after I told him 'A-this is a crisis, if I work or not, but I must work no matter what'

Just was a callous prick,and said 'well don't work then, not my problem if I don't make sure you are healthy enough to work' and besides you should have a license if you aren't employed by a uni or in research for the govt. etc. or else not work at all' when AFAIK, here at least, no such specific license actually exists.

Besides, the licensing of a man's activities and hobby, driving aside, things like what I do, that is the purview of a licensing authority, not a GP. And to the best of my knowledge, no such board exists and no license of the kind actually in reality, exists. He basically demanded I go and do what he thinks I ought to because he thinks personally that is how the world ought to work.

I never did get the medical treatment I required that day, although as soon as I could see someone else, (and keep in mind this was a thing instituted by a full time GP who partners the owner of the practice), they just said 'here you go, have a nice day'

I call dresden out not only for posting crap 'soul molecules' or whatever he worded it as? not even science there!, but for actively telling us lies on one page, and claiming the opposite on the next. Of two competing, opposing claims, one of them MUST be false, at least one, I mean, as minimum.

So he should have the guts to eat his words, retract the false statement as such, to us all, rather than pretending not to be a liar, or worse, for telling him straight up that the two statements (his 'established drug designer' statement' and his 'going to college to learn pharmacology/chemistry', those two are mutually exclusive, For asking him to prove this 'fuck off' is not even close to adequate, is it now? and yet he did so.

HAD I now abused him in the same manner, I don't doubt I would have been infracted. Its worse than his shitposting, it is lying to us all.


Rio-the point I was trying to make, was that whilst there are things that could be said to me in person, or where I could get to the speaker, that would bring out physical unpleasantness, insults, aren't them. There might be a few, very, very specific things said that would get that result, yes. But not one of them is about me or even genetic relations.

One individual could be targeted, and I'd flip my lid, anything anyone else, r anyTHING else, and I'd at most tell them (potentially in pretty colourful language all the same) where they can take it, turn it sideways and stick it. I've got a very thick skin indeed. And to care what DRESDEN of all thinks of me? I wouldn't justify his BS. There is a person who exists, who were someone to mouth off at them, I'd be more than willing to do rather unpleasant things to the speaker, otherwise and to even blood family, they'd just get told to go get fucked.

 

[Rio Fantastic]

Actually I really don't have sufficient regard for one who so inanely takes to insult me, to give enough of a damn to value him to the point of view he could easily insult me; yes, there are words that would result in my killing him on the spot, hut he will never know to/about who, or why. And that would apply to almost anyone, not just him.

Your ego is talking, Limpet. If this was true you wouldn't have to broadcast it. I hope you're on some kind of drugs making you speak like this, since I used to hold you in very high esteem, and I don't mean to be offensive but honestly from the outside you really look like a 12 year old trying to be edgy here, and I know you're better than that. If it was true that he couldn't insult you then you could just move past it, but the fact that you write a really long post about how unoffended you are doesn't reflect well on you.

 

[Limpet_Chicken]

If you write up a 'trip report' for a deity, then yes, I will flame you so flamed that your feathers have plucked themselves, used the stubs to butter your carcass, the oven turn alive and pull you in; before spitting you out with your giblets removed with your head, and your legs tied together so a cortically blind, jewish man (jewish not because Im being racist, but that they would never have smelled or tasted roasting pork, which primates of the ape variety are supposed to taste like when cooked and eaten) would come in and say 'mom? is that chicken roasting in the oven?'

Because that isn't just idle messing, you would be purporting to write a trip report for a deity, something nobody here has the least proof even that exists. And even were it for a human, writing a non-dictated TR for someone else is nothing short of or other than a lie.

BS whilst the rest of the people, and sekio (yes, you are people too, good people IMO ) tolerate these toilet-plungings of a heap of shit, IMO if/when he keeps LYING to us, that is more than just idiotic on his behalf, he is if so, taking all of US for idiots as well, and that I won't stand for. I'll go right to the forum staff top such as available to me, if he keeps that up, to get his arse kicked so hard his decendents (should anyone want to have anything to DO with him for whatever crack-whore-affected-by-the-clap once it infects the CNS-spawned reason that might possibly be) all come out of the womb with an arse cheek poking out of each ear canal.

Its one thing to be an obvious tool, another to present his stupidity as fact, but to start abusing people for telling them to back up a specific, definable claim he has made which blatantly isn't true (whether its true or not in fact, abuse is against the BLUA, I've been infracted for much less than I'd say to this....individual bipedal mammalian entity....in response to his claims.)

And worse still, is to tell LIES to us. Even if he isn't bright enough to make them anything but transparent, to tell us lies detracts from the forum even more than this thread of stinking efflient, and for that matter it shows the very height of disrespect to each and every single user of the forum.

I do not like liars, and I like them even less when they are warned and keep at it. My tolerance for the bastards is so low, you could fit it between spectral lines of an entire sodding periodic table. With room to spare so large one could within the remaining space, fit theresa may's dick and balls.

 

[Pomzazed]

Well, insulting or not just let it be @Limpet_Chicken, at lease this is Dresden's thread

As far as I'm concerned, he's just a reference sample of arsenacyclopentadiene held just barely around his melting point with really inefficient heating/cooling point. Haven't the energy to attempt to dimerize him and stick a comma in his middle

(you gotta give me that for a decent comeback, no? it was at least creative)

It is very creative, LOL! I got all what you imply except the comma thing, what is that refer to? an alkylation to prevent de-dimerization?
Anyway,

arsenacyclopentadiene

I keep LOLing several times as I'm typing this hahahah... I know what you did there!

 

[sekio]

Yes, the entire reason this thread exists is to cordon it off from people who don't like it, it's one thread on a board full of posts, if you don't like it nobody is forcing you to read it.

It seems to me that anyone who has more than a few active cells in the decision-making parts of their neocortex can judge Dresden's posts for their possible value with their own eyes and come to the same conclusion that it's a bunch of spiritualist hooey and not to be taken seriously.

 

[Limpet_Chicken]

The dimer bit, that was meant to go somewhere else in another post, I've got a fucky laptop with an even fuckier keyboard that at times takes to doing weird things with the mouse, and even weirder things with the cursor. Meant to say imply a highly impure (and what would we often call such compounds as have this quality..?) reference sample of arsenacyclopentadiene, anyhow. I just hope that the other place I was posting in didn't get reference to that, and wonder what on earth I was talking about that particular compound for haha.

Hehe, glad that one found its mark, Pomzazed. Might have been a bit corny, but I couldn't resist.

 

[Pomzazed]

Well, i got it now, as arsine quickly dimerized at rt to its dimer akin to Cp itself, resulting in a reddist brown product that mus tbe redistilled under cold vac fresh prior to use, and

dimerized arsenacyclopentadiene

^ lol, so that reads “crude arsine” (= crud arse)
Well, some of dresden post have their value, sometimes interesting molecules pops up when aligning things in 3D
It is a good excercise for “in-head” binding simulation without trying to put into computer and use CHARMM or MM2/MM94

Occasionally i can spot things binding to weird target, like being Adenosine Agonist (anti-caffeine, a sleep med with few addiction),
some weird selective 5HT subtype agonist, or some AHR agonist like prior post we just discussed.

So this post is kinda useful to me, and i hope he post a lot more, but just in this thread and not spreading to random place.

 

[Dresden]

For The First Time In 17 Years, I Now Have Acess To The Scientific Literature! I Am Going To The Library Today.

Be Expecting Good Things To Come To You From This Development.

 

[Limpet_Chicken]

Heh pomzazed, you one-upped me. I didn't mean 'crud arse', just 'crude arse'

But still. Either way, it works.

And dresden...sci-hub.TW

Even if you have legit access to the literature, use it. That way it takes money from the pockets of those shiteaters that are the big publishing houses. Apparently quite a lot of people with institutional access use sci-hub, just for that reason, because the publishing houses, like those Elsevier fucking bastards, rip the fuck out of unis, individual users (seriously....paying 40 quid, and thats at the cheap end, for 48 hours of read-only access, can't save, can't print, just read. For that, I'd expect to at least be able to print off a damn copy!)

I've no institutional access, but I've never PAID those cunts for a paper in my entire life. And I've probably read thousands, probably more, all through sci-hub.

Just plug the DOI in, and go. Help starve the big publishing house ratbastards!

 

[Pomzazed]

@Dresden
Yep, dont get burnt when you have accessed to literature lol.

That happened to me long ago in my university day, which these online things arent so available.
Most of the time i had to go to library and keeps looking where the hardcopy literatures are,
among the vast array of shelves x.x Nowadays it is so easy.

Even with that i keep reading alot for some few month then get burnt out lol
Its like playing too much fun game and suddenly dont want to touch it anymore.

 

[sekio]

Most university libraries I know of are more than happy to grant you free access to the stacks and the library web proxy, usually on a temporary 24-hour basis, even if you're a "civilian" who does not attend class. Ask the staff at the information/checkout desk. You've still got to pay for the photocopy fees though, so maybe instead just bring a point'n'shoot camera or your smartphone - taking pictures of an open book's pages is a little more expeditious than stuffing the thing into a photocopier or scanner.

However, I concur that sci-hub is the Way To Go, no fees whatsoever and you can fetch papers from the comfort of your armchair at home. Although then you'll miss the opportunity to see that one library staff member with the low-cut top and suggestive smile...

 

[Dresden]

KILLER WEED

haha

CHILLS

Take Me To Your Leader.

 

[Limpet_Chicken]

Sci-hub is definitely the way to go.

I've read that quite a lot of people with access are using it anyway now, because they are pissed at the way the publishing companies are shitting on people from the very top end of the ladder (I.e researchers themselves) to the very bottom end (people without institutional access), the only people not getting shat on, are the giant arseholes responsible for the shitting.

 

[Dresden]

MIRIAM

The biggest chance I took with this one was making it a carbamate. Hey people, don't take opiates indefinitely unless you are dying soon and short term only if you really need them.

CHOOSE LIFE, CHOOSE

AMPHETAMINE(s)!

Like 4 really, yo.

MORPHEUS, The Matrix, also Greek god of dreams.

ANTHONY HOPKINS; also (unrelated), SISSYPHUS, an immortal Titan.

SMOKIN' THAT DUST AT SAINT ANTHONY'S FEAST!

BUTTHEAD from MTV.

IV some. I D.A.R.E you!

PYLON

THE B-52's

GWAR

4-Aco-amp: PANSY DIVISION
N-ethyl-4-AcO-amp: THE VIOLENT FEMMES

N-Methyl-3,4-di-AcO-amp: REM
N-Ethyl-3,4-di-AcO-amp: JUCIFER

All these acetoxy thingies would have to be smoked or IVed. 4 subs, Aquarius, LGBTQI, Uranian, eccentric genius indicator. 3 goes with Sagittarius.
3,4 --> 7, Pisces.

This time, it's GWAR!!!

 

[sekio]

Unfortunately, the poly-hydroxy-amphetamines would seemingly be nothing but (relatively awful) adrenergic/perhipheral dopamine receptor ligands ... it iz, 'ow you say, very polar, und zo not zo good for ze BBB penetration, yes?

Also you'd pee them out quickly, and your liver would just love to put some sulfates or glucuronides on those lonely hydroxy groups, making them increasingly likely to become urine-bound, sulfates doubly so (salt formation, which dooms BBB penetration in 93 out of 100 cases).