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Ketamine salts solubility

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1-(4-ethylphenyl)-2-ethylaminopropane.png


DANNY
1-(4-ethylphenyl)-2-ethylaminopropane
 
4-phenyl-3-oxo-4-(1-(2-phenyl-1-methylethyl)-piperidin-4-yl)butane.png


OP8UP
4-phenyl-3-oxo-4-(1-(2-phenyl-1-methylethyl)-piperidin-4-yl)butane

aka carba-AMF, where 'carba' indicates N --> C using replacement nomenclature.
 
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The N being just one C away from the SO2 functional group is a no go, right?

5-(3-methoxyphenyl)-5-(1-piperidinyl)-bicyclo%5b2.1.2%5dheptane.png


THE_INCREDIBLE_HULK
2-(3-methoxyphenyl)-2-(1-piperidinyl)-bicyclo[2.1.2]heptane

You're right. This one might be impossible, too.

Anyway I've been drawing these molecules all day, but the most promising are probably TALISHA and FENYL_FEINDING and their 3,4-MDO and 4-MeO analogues. At least, I feel as though they could definitely be made. But, then again, that might just be me being naive.
 
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2,6-dimethyl-3,5-bis-carbomethoxy-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


SWEET_CAROLINE
2,6-dimethyl-3,5-bis-carbomethoxy-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3,5-bis-phenyl-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


AROMATICITY
2,6-dimethyl-3,5-bis-phenyl-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3-phenyl-5-carbomethoxy-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


HUCKEL'S_RULE
2,6-dimethyl-3-phenyl-5-carbomethoxy-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3,5-bis(4-methoxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


NUMINOUS
2,6-dimethyl-3,5-bis(4-methoxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3,5-bis(3,4-methylenedioxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


VOLUMINOUS
2,6-dimethyl-3,5-bis(3,4-methylenedioxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3-(3,4-methylenedioxyphenyl)-5-(4-methoxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


BURNING_MAN
2,6-dimethyl-3-(3,4-methylenedioxyphenyl)-5-(4-methoxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3-carbomethoxy-5-(4-methoxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


RIGOROUS
2,6-dimethyl-3-carbomethoxy-5-(4-methoxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

2,6-dimethyl-3-carbomethoxy-5-(3,4-methylenedioxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene.png


VOCIFEROUS
2,6-dimethyl-3-carbomethoxy-5-(3,4-methylenedioxyphenyl)-N-methyl-1-aza-4,4-dimethyl-cyclohex-2,5-diene

1-aza-3-carbomethoxycyclohex-2-ene.png


BETELGEUSE
1-aza-3-carbomethoxycyclohex-2-ene

N-ethyl-1-aza-3-carbomethoxycyclohex-2-ene.png


SOUTH_ARECOLINE_CAROLINA
N-ethyl-1-aza-3-carbomethoxycyclohex-2-ene

N-methyl-1-aza-3-carbomethoxycyclohex-2-ene.png


NORTH_ARECOLINE_CAROLINA
N-methyl-1-aza-3-carbomethoxycyclohex-2-ene
 
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2-methyl-3-(2,5-dimethoxy-4-methylphenyl)piperidine.png


MARILYN
2-methyl-3-(2,5-dimethoxy-4-methylphenyl)piperidine

2-methyl-3-(2,5-dimethoxy-4-methylphenyl)-4-oxapiperidine.png


ROSE
2-methyl-3-(2,5-dimethoxy-4-methylphenyl)-4-oxapiperidine
 
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Ethylenediaminetetra-acetic%20acid.png


EDTA
EthyleneDiamineTetra-Acetic acid

Using EDTA as the solvent in the Birch Reduction [Li metal; anhydrous NH3 or ammonium nitrate, NH3+NO2] of PPA or ephedrine to amp or methamphetamine makes the reaction work in just 60 seconds aka 1 minute!
 
as I am blind, I’m not sure if you’re all posting images of the molecules you propose, Plus I’m no expert in chemistry. however, just want to suggest deschlorobupropion. that would be bupropion without the chlorine atom in the molecule. Of course, that chlorine atom would have to be replaced by a hydrogen. does anyone know what the pharmacological properties of this molecule could be?
 
Stronger stimulation but less color enhancement. Probably has to be snorted or injected to give the desired effects, like bupropion. Here, let me post the structure we're talking about:

N-tert-butyl-1-phenyl-1-oxo-2-aminopropane.png


NEUROPROTECTION
N-tert-butyl-1-phenyl-1-oxo-2-aminopropane

There you go, I even named it after your username.
 
2-benzyl-1,3-diaza-cyclopent-1-ene.png


HERCULES
2-benzyl-1,3-diaza-cyclopent-1-ene

2-piperonyl-1,3-diaza-cyclopent-1-ene.png


SUSAN
2-piperonyl-1,3-diaza-cyclopent-1-ene

2-(4-methoxyphenylmethyl)-1,3-diaza-cyclopent-1-ene.png


PERSEUS
2-(4-methoxyphenylmethyl)-1,3-diaza-cyclopent-1-ene

2-(4-bromo-2,5-dimethoxyphenylmethyl)-1,3-diaza-cyclopent-1-ene.png


RED_FOX
2-(4-bromo-2,5-dimethoxyphenylmethyl)-1,3-diaza-cyclopent-1-ene
 
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Neuroprotection said:
as I am blind, I’m not sure if you’re all posting images of the molecules you propose, Plus I’m no expert in chemistry. however, just want to suggest deschlorobupropion. that would be bupropion without the chlorine atom in the molecule. Of course, that chlorine atom would have to be replaced by a hydrogen. does anyone know what the pharmacological properties of this molecule could be?
Click to expand...

Removing that meta chloro moiety will increase the activity of the drug, Specifically it will engender at least some SERT activity and most likely increase reuptake inhibition of all three monoamines.
 
Rectify said:
Ethylenediaminetetra-acetic%20acid.png


EDTA
EthyleneDiamineTetra-Acetic acid

Using EDTA as the solvent in the Birch Reduction [Li metal; anhydrous NH3 or ammonium nitrate, NH3+NO2] of PPA or ephedrine to amp or methamphetamine makes the reaction work in just 60 seconds aka 1 minute!
Click to expand...
This one I'm quite fond of. So many uses.
 
AlsoTapered said:
It's a chelating agent - so it's often used to treat metal poisoning.
Click to expand...
It also inhibits a bunch of enzymes, especially proteases (pretty much anything with a metal active site), can elute proteins of nickel chromatography resin, can be bacteriostatic, and can stabilize unstable things due to metals.
 
Birch reductions are a class of reaction. With regards to the use of ETDA, it would appear that it's more generally applicable to the reduction of aromatic rings:


pubmed.ncbi.nlm.nih.gov

Scalable Birch reduction with lithium and ethylenediamine in tetrahydrofuran - PubMed

The Birch reduction dearomatizes arenes into 1,4-cyclohexadienes. Despite substantial efforts devoted to avoiding ammonia and cryogenic conditions, the traditional, cumbersome, and dangerous procedure remains the standard. The Benkeser reduction with lithium in ethylenediamine converts arenes to...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

So it wouldn't be of much use in the reduction of a benzylic hydroxyl.

I'm quite prepared to read any papers in which ETDA is used for that specific class of Birch reduction.
 
AlsoTapered,

You are often right, but this time you are just flat out wrong. I read an article 2 months ago that said exactly what I wrote. I am not going to argue with you or be called wrong about this. I am beginning to wonder if you are an argumentative AI chatbot.
 
Removing the electron withdrawing 3-chloro makes the compound *less* serotonergic.
 
1-phenyl-1-methoxy-2-ethylaminopropane.png


ETHEREAL
1-phenyl-1-methoxy-2-ethylaminopropane

1-(3,4-methylenedioxyphenyl)-1-methoxy-2-ethylaminopropane.png


SULTRY_SHEIK
1-(3,4-methylenedioxyphenyl)-1-methoxy-2-ethylaminopropane

I Give Your Mind A Blow Job Every Time!
 
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