Juniper Bruhmomentius
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BDD Moderators: Keif’ Richards | negrogesic
Opioids Does hydroxyzine really potentiate opioids?
- Thread starter Juniper Bruhmomentius
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jackie jones
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Not really. It helps with the itches and has very mild sedative effects, but does not have any appreciable effects to speak of for us drug users.
Juniper Bruhmomentius
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Ok thanks
Nicomorphinist
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Some more than others -- and other piperazine antihistamines like cyclizine and meclizine/meclozine also have the general potentiating effect and have special effects it seems with some, like increasing the CNS effects of loperamide, difenoxin, diphenoxylate and other 4-phenylpiperidines, and especially the effect that cyclizine has on the rush of dipipanone, phenadoxone, and other methadone relatives, which is also caused by the others.
There is enough of an effect with hydroxyzine that physicians and pharmaceutical manufacturers use them with the above and codeine, dihydrocodeine and others. For a long time I was on dihydrocodeine and hydroxyzine for chronic pain with orphenadrine added soon after and then the dihydrocodeine changed to morphine plus tripelennamine to be taken along with the hydroxyzine and orphenadrine. Morphine and cyclizine are mixed into Cyclomorphine, dipipanone and cyclizine are Diconal, there is a generic pethidine with hydroxyzine and pethidine with promethazine is available and there once was a mixture known as Mepergan (MEPeridine + PhenERGAN) Tripelennamine and codeine, DHC, or hydrocodone are common cough mixtures, and sometimes doctors will add a low dose of hydroxyzine at bedtime if it is a dry violent cough keeping one up at night.
There is also somewhat less of an anticholinergic effect, and it does not really overlap with the ethanolamines, ethylenediamines, or other antihistamines in those respects; for example, the orphenadrine and tripelennamine effects have been still there when I take hydroxyzine with those two and just about any other narcotic analgesic. The anticholinergic effects that are there seem to be additive rather than synergistic.
There is enough of an effect with hydroxyzine that physicians and pharmaceutical manufacturers use them with the above and codeine, dihydrocodeine and others. For a long time I was on dihydrocodeine and hydroxyzine for chronic pain with orphenadrine added soon after and then the dihydrocodeine changed to morphine plus tripelennamine to be taken along with the hydroxyzine and orphenadrine. Morphine and cyclizine are mixed into Cyclomorphine, dipipanone and cyclizine are Diconal, there is a generic pethidine with hydroxyzine and pethidine with promethazine is available and there once was a mixture known as Mepergan (MEPeridine + PhenERGAN) Tripelennamine and codeine, DHC, or hydrocodone are common cough mixtures, and sometimes doctors will add a low dose of hydroxyzine at bedtime if it is a dry violent cough keeping one up at night.
There is also somewhat less of an anticholinergic effect, and it does not really overlap with the ethanolamines, ethylenediamines, or other antihistamines in those respects; for example, the orphenadrine and tripelennamine effects have been still there when I take hydroxyzine with those two and just about any other narcotic analgesic. The anticholinergic effects that are there seem to be additive rather than synergistic.
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