I'd assume it'd be more often than not the opposite of the original proposition in the original post; phenotypically discernible physiological re-actions to acute cessation to a compound that are not the direct influence of the MoA of the drug in question (but are the bodies way or readjusting and calibrating to the immediate loss of its former but artificial baseline); you can't tell when damage is being done, but reeling from effects, now that is a quantifiable experience which overwhelmingly (or so I presume seeing as it is sensible to do so) is more of the neurological healing process than "cut and dry"/wholly-unwarranted, isolated, instances of full-on dysfunctional damage that was done and which isn't a pendulum compensation that your body is doing to show its caring for itself (the latter which I'd more readily presume it to be, than cringing in fear of it being a sign of damage. Let's just say, in many ways (and I am speaking of "you" in a rhetorical, general sense of the quintessential "everyman") you aren't as smart as your brain is when it comes to how to react to stimuli).
