MephedroneCandy
Bluelighter
- Joined
- Mar 18, 2022
- Messages
- 88
If you started antipsychotics for schizophrenia and they work, do not stop them because of cognitive deficits. An hypodopaminergic tone in most regions in the brain except the striatum which is hyperdopaminergic is normal for schizophrenia and it is responsible for the negative symptoms and partially for hallucinations. Risperidone for example exacerbates this hypodopaminergic state in favor of rebalancing striatum.
Abilify fixes it by being a partial agonist instead of antagonist, so you can try switching to it. Cognitive deficits should get better than other antipsychotics, or possibly better than baseline. If you still want improvement you can very carefully add lisdexamphetamine to the treatment ALWAYS when you are already stable on antipsychotics. With lisdexamphetamine you can rebalance all hypodopaminergic regions and so treat all the negative symptoms of schizophrenia, while still having protection from positive symptoms by antipsychotics.
The lack of treatment for negative symptoms contributes to the reason of why some schizophrenics do still have positive symptoms when on antipsychotics. For example because the hypodopaminergic tone is associated to hearing problems, it goes in synergy with positive symptoms since the brain is forced to predict with low confidence aka hallucinate to understand the confused stuff it hears. But psychiatrists don't even know if they're alive, so this isn't being addressed as it should be.
Whatever you choose, I don't think just don't taking nothing is a good solution for a schizophrenic patient because there is good potential of a normal or better than normal quality of life thanks to the right treatment. Good luck!
The best antipsychotic to take when in combination with lisdexamphetamine is something that is more selective on 5ht2a antagonism such as brexpiprazole, maybe using a small dose of haloperidol as augmentation if it is not enough. So it will inhibit dopamine neurons firing selectively on the hyperdopaminergic region and the hypodopaminergic ones can be treated with a stimulant.
Some source if the logical explaination isn't enough: https://www.nature.com/articles/npp2013111
Abilify fixes it by being a partial agonist instead of antagonist, so you can try switching to it. Cognitive deficits should get better than other antipsychotics, or possibly better than baseline. If you still want improvement you can very carefully add lisdexamphetamine to the treatment ALWAYS when you are already stable on antipsychotics. With lisdexamphetamine you can rebalance all hypodopaminergic regions and so treat all the negative symptoms of schizophrenia, while still having protection from positive symptoms by antipsychotics.
The lack of treatment for negative symptoms contributes to the reason of why some schizophrenics do still have positive symptoms when on antipsychotics. For example because the hypodopaminergic tone is associated to hearing problems, it goes in synergy with positive symptoms since the brain is forced to predict with low confidence aka hallucinate to understand the confused stuff it hears. But psychiatrists don't even know if they're alive, so this isn't being addressed as it should be.
Whatever you choose, I don't think just don't taking nothing is a good solution for a schizophrenic patient because there is good potential of a normal or better than normal quality of life thanks to the right treatment. Good luck!
The best antipsychotic to take when in combination with lisdexamphetamine is something that is more selective on 5ht2a antagonism such as brexpiprazole, maybe using a small dose of haloperidol as augmentation if it is not enough. So it will inhibit dopamine neurons firing selectively on the hyperdopaminergic region and the hypodopaminergic ones can be treated with a stimulant.
Some source if the logical explaination isn't enough: https://www.nature.com/articles/npp2013111
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