Thanks for that, pretty great info..
It's mentioned that QSAR shows a similar pattern to arylcyclohexylamines, in terms of potency vs different MeO subsitutions. Not unexpected considering the overlapping structure. Comparing 3-MeO-PCP with 3-MeO-PCE they seem largely similar, with 3-MeO-PCE having more affinity for sigma2. MXE on the other hand apparently lacks this, and is also an N-ethyl compound.
I think you'd expect ephenidine to have higher NMDA affinity, but no crazy differences as far as I can tell. But of course it remains a guess.
I wonder if many other dissociatives have effect on prepulse inhibition, but apparently this can mess with ability to filter out useful information from stimuli? (Yes apparently not only NMDA antagonists but also serotonergic psychedelics can cause this, and dopamine agonists.. at least this is being studied and suggested)
Differences in subjective experience between these compounds may also be explained by their trapping abilities which were not studied.
