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  • BDD Moderators: Keif’ Richards | negrogesic

Diphenhydramine Hydrochloride and alcohol?

wheaters

Bluelighter
Joined
Oct 25, 2015
Messages
111
so ive been recently using 50mg of [FONT=Arial, Helvetica, sans-serif]Diphenhydramine Hydrochloride to help me sleep (yesterday - first day) and i also had around 20 units of alcohol. TBH i had the best sleep ever and i plan on doing the same tonight im just wandering how dangerous this is even tho im having the minimal dose of [/FONT]Diphenhydramine Hydrochloride.

thanks for the responses ^^
 
20 units of alcohol? That's dangerous by itself, 2 Benadryl are the least of your problems.

Also, off to BDD, for the booze and Benadryl experts.

(Yes, I now that's technically me, but I said my wisdom already)
 
normally if i drink i have around 20 units minimum :S well... 8-10x 2.2unit drinks but im just wandering how dangerous this is to CNS depression or do i need a lot more of each?

I should maybe add that i often have 20+ units every night ...
 
Why do you feel the need to consume as much as 20 units? how spread out are these doses? If the alcohol amount wasn't so high I wouldn't be slightly worried about mixing it with a threshold dose of DPH. Do not take moderate/high doses of alcohol and DPH together, that could cause some problems.
 
suppose im an "alcoholic" i guess, idk but i just normally drink 8x 2.2 unit drinks without even thinking it has been this way for years...i still have the odd day off with no ill effects, even 2-5 days. I just recently found these pills and found i had a great sleep + the effect for the time before sleeping was pretty good :p curious how they interact, since i dont want CNS depression x)

17.6 units to be exact is just a average week day for me ... i realize that probs comes across badly but normally within 3-4 hours?

its a bit of an eye opener that this is deemed as a lot as 20 units is a "chill out" dose and i dont really get drunk from this.
 
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I believe benadryl behaves differently than CNS depressants, and does not typically cause respiratory depression.. Therefore it is not physically dangerous to take with other downers. I think, as was said previously, alcohol is your primary concern. I might be wrong on this but that is how I understood it.
 
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Look, 20 units of alcohol is obviously too much for anyone, but it's also not jaw-dropping record setting.

This isn't a contest, but you could pick one of your booze stats at random, and I'm fairly confident I'd have you beat. Some of that is just because I'm much older, it's not an accomplishment. Anyone can keep it up and become a homeless frequent flyer.

So I know what 20 units is like. I don't use or endorse the term "alcoholic," which means "anyone whose drinking bothered someone (note past tense)" and is not defined by number of drinks. I'm not going to critique or evaluate your habit beyond saying what you already know: it's too much, unsustainable.

But at that level, you ask if two Benadryl are dangerous? They will make your blackout chances go up, for sure, hopefully they'll knock you out before you get to 30 units. But you have bigger problems than diphenhydramine right now.

ETA, after Mr. Pickled: it's true that it's a downer through a different brain circuit, but that doesn't make it safe. Benzos and opioids are also on different circuits.

It doesn't depress your breathing, but then alcohol doesn't either, compared to opioids. The problem is it will intensify memory lapse, from the anticholinergic traits of the DPH, it will worsen your clumsiness, inability to walk straight, don't get near a car, fall-on-your-face joys that alcohol so lovingly provides.

So it is dangerous because you will blackout sooner and hurt yourself or others when you do.
 
thankyou for the reply! i am by no means wanting to say my alcohol consumption is "big" or anything just putting the honest answer out there to get a real response i appreciate everybodys! just was curious if the drugs were very dangerous. I am no longer going to continue so much alcohol, but thank you all for the input!
 
Diphenhydramine and alcohol are relatively safe together so CNS depression wouldn't be an issue. There would be the likelihood of increased side effects though. I see why it would be appealing to use them for sleep. Trouble is, you will get a tolerance with Benadryl the same way you got with the alcohol. Before long, it will not work the same as it did last night and you'll be back to square one sleep-wise.

Both of these are dehydrating on their own so together your chances of getting hungover the next morning are greater. I used to drink quite a bit so no judgment from my end. But if 20 units is your chill-out dose, I would hate to see your get loaded dose. My liver hurts thinking about it! A nightcap or two can help with sleep. However, high levels of blood alcohol content is detrimental to sleep architecture. My best advice is try cutting back a bit.
 
As a 175 pound male, I have drank that much and taken the dose of Benadryl that you mentioned on a number of occasions. Not all the time or anything, but it's something I've done from time to time. Certainly, it never resulted in "getting a good sleep" though. Just basically passing out either in bed or in my recliner and waking up feeling like shit the next day. So, I'm quite surprised that you felt like you got a good sleep. However, mixing that much alcohol with Benadryl certainly can't be good for your physical health. I usually drink 10-12 units myself a night, but when I go beyond my usual amount I typically get a hangover. My "chill out" dose booze wise is usually a tall boy of high alcohol beer (a nice imperial stout or imperial ipa or if I'm on a budget a steel reserve) along with a couple shots of 100 proof vodka or a couple 16 ounce cans of 6-8% craft beer and a couple shots of this interesting vodka I drink that has a vanilla flavor to it. Even with my usual amount, I have never felt like booze really gave me a better sleep. Just a "buzz" that I enjoyed and perhaps helped me to get to sleep earlier as sometimes without alcohol I'll stay up late as fuck (e.g. staying up until 5 AM). I don't know why. I'm self employed, so I likely wouldn't stay up so late otherwise but since I am I still don't really like staying up till 5 sleep schedule wise even though I'm self-employed and can set my own schedule. Overall, I wouldn't recommend drinking 20 units a night to anyone. In fact, according to rational doctors (e.g. not the CDC's information of "two standard drinks a day for males and one for women" which I feel is nothing other than government brainwashing and state-sponsored propaganda a.k.a. fake news in my opinion), drinking more than around a bottle of standard ABV wine 10-12% or around a six pack of 4.2-5% of beer a night is potentially dangerous as far as liver health though the effects vary for everyone.

However, not everyone experiences liver damage. Some who drink more than this amount, even by a lot are fine. However, others who exceed this amount experience long-term deterioration in liver function that can even prove fatal in some cases. According to statistics, around 20% of people who drink amounts that are large enough to cause this damage experience problems with their liver. Still, drinking 20 units a night, on a typical night is definitely too much and could cause serious problems. As far as I know, there is no particular risk with regard to combining alcohol and diphenhydramine in terms of immediate effects. Although, adding another substance to the mix certainly increases the strain on your body to remove it. In the immediate sense, I've suffered no ill effects from this. Though, mixing them both regularly would increase the potential for issues. Also, I suggest taking some nights off from alcohol if you also drink every night. This will likely help to prevent damage from it and also lessen your chances of physical dependence if you are a "drink every night" type of person like I am. As much as it seems to "suck" to not drink at night, as a daily drinker, I find that 90% of it is psyching myself out. And the actual experience of not drinking one or even two nights is not a big deal, I just build it up in my mind as a "big deal". So, after having seen this, in a way I can take it or leave it to be honest. Drinking at night is a mere preference for me and not a necessity. If you drink every night, I'd also really recommend going without for a night to see how that is. At least, take a night off every now and then.
 
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I used to do the reverse and combine a handful of diphenhydramine(250-300 mg) with one or two units of alcohol and never had any dangerous side effects. For what you're after there's probably a much better way of getting to sleep than drinking to high heaven and popping a couple anti-histamines. I was after something different, a more hallucinogenic/stimulant/aphrodisiac effect rather than a knockout experience and the alcohol dulled all three of those effects.

I hate to admit it but I miss the epic porn marathons diphenhydramine would induce. I would go from completely uninterested in sexual stimuli to almost climaxing just flicking through some of my favorite pics/videos before I even engaged in any physical stimulation. It really did a number on my mind and reward circuits long-term so it wasn't worth it, I'll never be able to feel that aroused on any other drug or just plain sober again I fear. I got into NoFap to try and gain my libido back and its somewhat worked but I still fantasize about taking some diphenhydramine and going on another marathon.

Sorry for this whole post, your thread has made me nostalgic.
 
ETA, after Mr. Pickled: it's true that it's a downer through a different brain circuit, but that doesn't make it safe. Benzos and opioids are also on different circuits.

It doesn't depress your breathing, but then alcohol doesn't either, compared to opioids. The problem is it will intensify memory lapse, from the anticholinergic traits of the DPH, it will worsen your clumsiness, inability to walk straight, don't get near a car, fall-on-your-face joys that alcohol so lovingly provides.

This is wrong. First of all, same receptors or not, both benzos and opioids depress breathing on their own, and especially in combination it can result in respiratory failure. Alcohol, being a GABA-A positive allosteric modulator like benzos and barbs (although not certain which it's closer to), also depresses breathing. The two most likely mechanisms for death in alcohol overdose are 1) choking on your own vomit; 2) plain ole respiratory depression.

That said, diphenhydramine doesn't depress breathing AFAIK, so it shouldn't add to the fatal OD danger, which by my understanding you're not facing anyway as 20 units just gets you chilled out. I'm also in the same boat with I don't-even-want-to-calculate-how-many units per night every night and I'm less drunk than a normal person would be from 2 beers, so fatal CNS depression seems to be far away as long as you control your intake.

E: in regards to CNS depression from the alcohol, I understand that the OP has been drinking daily for at least a year. I personally have been back on the juice daily for around 6 months now. As an example, I calculated that yesterday I had 21 units of alcohol, which is actually around the average for me, over 4 hours, and by the time I went to bed I was as intoxicated as I would be from 1 beer without tolerance; I definitely was nowhere near drunk. Slight withdrawal started creeping up by 4 AM. Obviously this is pure conjecture, but I imagine I'd need 40 drink in the same time period to be in any danger of respiratory failure if not more.

Point is, for a person with alcohol tolerance like the OP seems to be, judging from their dosage and subjective evaluation, dangerous CNS depression is not a danger.
 
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Thanks to everone for all the responses! Im going to actively cut down the amount of units i drink, and start having more than 1-3 days off per week :) bluelighters as helpful as ever <3
 
AngrySot said:
This is wrong. First of all, same receptors or not, both benzos and opioids depress breathing on their own, and especially in combination it can result in respiratory failure. Alcohol, being a GABA-A positive allosteric modulator like benzos and barbs (although not certain which it's closer to), also depresses breathing. The two most likely mechanisms for death in alcohol overdose are 1) choking on your own vomit; 2) plain ole respiratory depression.

If you've ever tried to sleep with a passed-out drunk nearby, you know from his snoring that his breathing hasn't been depressed. And yet if he was that intoxicated on opioids, people would call it an OD. At therapeutic levels of opioids, breathing is already depressed slightly. They have (and not all of them) a unique kind of respiratory depression, not the same as the respiratory failure you get when you die. Benzos in general do not produce that, and is why deaths from pure-benzo overdoses is rare.

Alcohol is a messy drug, and death from alcohol overdose has many mechanisms, including respiratory failure, which might be caused by acidosis, and not involve any neurotransmitters.

The main cause of death for drunk young and young-ish people is accidents, and blackouts are often when those happen. I've eaten 2.5g DPH while drunk on foot in traffic. I lived. But what would have killed me would be a car or the police, not my depressed breathing.
 
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