Misc Diphenhydramine four nights in a row?

[crawlingfish]

Thursday was 250mg, Friday was 350mg, and last night I took 450mg. Really enjoyable experiences, each time has gotten better, but I want more of an adrenaline rush from the increased sensations/fear that people reportedly get at higher doses.
I don't feel "off" today or anything, do you think I can push it up to 600-700mg tonight without spending tomorrow completely hungover?
(I am a 22 yr old, 140-lb male. I realize that some people state that taking DPH several days in a row can give you a permanent hallucinatory condition, but, being a schizophrenic to start with, this doesn't really dissuade me.)
Thoughts?

 

[Jabberwocky]

Certainly whatever hangover you have noticed will just become stronger if you consume a larger dose again tonight.

 

[Jessssssssee]

Can you write us a trip report ive been a long time lurker but i would be really interested thanks.

 

[Jabberwocky]

I'd be interested in reading it too. I'm still trying to wrap my head around high dose diphenhydramine use. I don't judge at all, I just can't imagine I'd find it pleasant.

 

[Jessssssssee]

I'd be interested in reading it too. I'm still trying to wrap my head around high dose diphenhydramine use. I don't judge at all, I just can't imagine I'd find it pleasant.

haha took the words out of my mouth

 

[d1nach]

I took 175 mg twice today twelve hours apart.
Just made me feel really emotional and listen to music for a teenage girl and drink almost a gallon of milk.

I would be very careful because it blocks sodium ion channels which can make your heart go into failure i forget the word.

Also it antagonizes muscarinic acetylcholinergic receptors which play a role in your heart increasing parasympathetic tone.

Additionally it blocks potassium ion channels.

Abnormalities of sodium and potassium ion channels can cause sudden death and and increase the sensitivity of the heart to adrenaline esp when blocking mACh.

In short, if you feel like your sick dont be afraid to call 911. Benadyrl at high doses blocks vital signaling to keeping you alive and they can quickly determine if you need acetylcholinesterase inhibitor, iv saline, mineral ect.

 

[Jessssssssee]

I took 175 mg twice today twelve hours apart.
Just made me feel really emotional and listen to music for a teenage girl and drink almost a gallon of milk.

I would be very careful because it blocks sodium ion channels which can make your heart go into failure i forget the word.

Also it antagonizes muscarinic acetylcholinergic receptors which play a role in your heart increasing parasympathetic tone.

Additionally it blocks potassium ion channels.

Abnormalities of sodium and potassium ion channels can cause sudden death and and increase the sensitivity of the heart to adrenaline esp when blocking mACh.

In short, if you feel like your sick dont be afraid to call 911. Benadyrl at high doses blocks vital signaling to keeping you alive and they can quickly determine if you need acetylcholinesterase inhibitor, iv saline, mineral ect.

SORRY but I find all that quite hard to beleive that they would sell something so dangerous ive had it plenty of times with no side effects and never heard of of this blocking of vital body signalling either I hope is aint true anyway lol.

 

[Jabberwocky]

I think they're talking about super high doses, significantly higher than 200mg.

 

[d1nach]

otc drugs like aspirin antihistamines alcohol tobacco ect i believe disproportionly account for drug overdose hospitalization and early death.

You cant trust that what is in the store is safe once you take more than what is on the bottle.

You can buy a gun, knife or blow torch at the store that doesnt mean they wont kill you if you use them wrong because they are over the counter. A guns thats are not illegal from Generic Store can be just as fatal as a gun from some guy in a trenchcoat behind the store.

 

[JahSEEuS]

Thursday was 250mg, Friday was 350mg, and last night I took 450mg. Really enjoyable experiences, each time has gotten better, but I want more of an adrenaline rush from the increased sensations/fear that people reportedly get at higher doses.
I don't feel "off" today or anything, do you think I can push it up to 600-700mg tonight without spending tomorrow completely hungover?
(I am a 22 yr old, 140-lb male. I realize that some people state that taking DPH several days in a row can give you a permanent hallucinatory condition, but, being a schizophrenic to start with, this doesn't really dissuade me.)
Thoughts?

What meds are you taking for your condition?

Taking such high amounts of Diph can cause some serious health issues, especially heart/liver failure.

What do you find so enjoyable about the experience?

I've done 300 mg once. It wasn't fun, or enjoyable. It was interesting to see my brain could be manipulated into seeing things that weren't there, but nothing novel about it in my humble opinion.

I'm surprised none of the HR specialists here picked up on the fact that you are abusing otc drugs that cause hallucinations/delusions. You should stop doing this immediately.

 

[d1nach]

I like how it stops the voice my head and overpowers me. 175 mg to 225 mg makes me feel discomfort but i guess i take it because i want to helpless sometimes over something i kno wont last

 

[Jabberwocky]

Totally. I might not understand the particular desire to consume DPH recreationally, but I do understand that we all find our own ways of meeting out needs like this.

I never had issue combining highish doses like 200mg with an opioid to increase the sedation and whatnot, but outside of opioid potentiation never been my thing. To each one's own.

d1nach, any reflection on your experiences or knowledge about DPH you have to share is appreciated. How much research have you done into the potential side effects and issues with high dose DPH?

 

[d1nach]

I really do not find it enjoyable on its own. If anything its incredibly dysphoric. I take it before my amphetamines because i like the feeling of being held down in the bed. Its hard to explain i just listen to like lana del ray or mars argo. It feels almost like someone has their hand over my mouth and wrapped around me and i could get up but its just too much of a fuss. And i can barely do anything and feel this intense uneasy anxiety and so i feel more comfort from bands like paramore just lying with my eyes closed. Instead of always being speeding feeling like i have to control everything and fix everything blasting death metal and ganster rap.

 

[d1nach]

My biggest concern would be a interaction between the opiates and benadyrl at sodium and potassium ion channels especially HERG. Especially since other sedatives like alcohol also interact with ion channels.

However other issues may be
Cocaine + Dph sodium ion channel sudden death
Amphet or cocaine + dph extremely high amounts of sympathetic signaling in the heart via mACh antagonism

DPH in general
-severe skin and mouth damage
-bowel obstruction and paralysis
-bladder damage
- severe agitation and delusions
-very very vivid hallucinations of bugs
-double vision
-extreme confusion
-amnesia

 

[Nod Alot]

I've had some crazy experiences with Benadryl. Originally I would mix it with 100mg morphine pills (IV'd) for potentiation. But when I couldn't afford morphine I would shoot the Benadryl by itself cuz if gives a lil rush, and I'd end up going overboard and be stuck in a miserable state of blurry vision and extreme confusion. I'd have a hard time forming sentences when talking and don't even get me started about the memory loss. I can't emphasize enough how severely forgetful it makes you in high doses. And then you get a paradoxical effect when it comes to "drowsiness". Sleep becomes damn near impossible.

 

[Slow_Mobius]

A friend of a friend ODed on DPH. I can't remember what exactly happened, but from what I do remember, it was pretty brutal