ecstacylover
Bluelighter
- Joined
- Nov 26, 2014
- Messages
- 699
I know that monoamine transporter inhibitors work by having a higher affinity for the transporter than the endogenous ligand, thus blocking it from being bound and uptaken.
A substrate would basically do the same, but I understand that it is also transported into the cytoplasm in the manner of the endogenous ligand.
I would assume that not all inhibitors are substrates, due to steric hindrance, etc., but are there any reliable methods of determining this? If anyone has any good sources I'd be interested.
The main reason I'm interested is because some receptors are intracellular, so the drug must either be transported into the cell or diffuse across the membrane to interact with them.
A substrate would basically do the same, but I understand that it is also transported into the cytoplasm in the manner of the endogenous ligand.
I would assume that not all inhibitors are substrates, due to steric hindrance, etc., but are there any reliable methods of determining this? If anyone has any good sources I'd be interested.
The main reason I'm interested is because some receptors are intracellular, so the drug must either be transported into the cell or diffuse across the membrane to interact with them.