Dextro- and levo-methamphetamine?

[Survival0200]

Why do they tell in cases of normal amphetamine, if it's dextro- or not? I mean, if I check up Dexedrine from RxList, it says "dexamphetamine hydrochloride". Why doesn't it say "dexmethamphetamine hydrochloride" in the description of Desoxyn?

 

[hussness]

Because trade names can contain as much or as little chemical information as the company would like. Like Escitalopram is really S-Citalopram; there are varying levels of specificity.

 

[Helios.]

^what hussness said.

It probably has to do with the order in which the drugs came out in.

For instance, first Company A gets permission to market amphetamine and then Company B comes along and gets to market dexamphetamine (as a 'new' drug).

As for Desoxyn, it is indeed (S)-methamphetamine.

 

[Riemann Zeta]

Desoxyn is (S)-N-methyl-amphetamine because the (l)-enantiomer of methamphetamine is worthless as a CNS stimulant and simply adds PNS stimulation.

 

[chipper2]

When people usually have meth, meth that they've bought from the streets in crystal form, is it dextro-, levo- or racemic methamphetamine? People usually just talk about meth, crank and methamphetamine. No one ever says anything about dextro- or levo- forms of methamphetamine. The selegiline topic made me think about it (selegiline metabolizes into l-methamphetamine and l-amphetamine). So, how is it? I'd of course assume that the street meth would be d-meth, but you never know. Just wanted to make sure.

There is also d-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine and it metabolises into d-meth and d-amph.

It may or may not be controlled in your country but I believe it to be quite expensive even if you are a registered researcher.

Like other metabolised prodrugs, abuse is much less of a problem.

 

[Rectify]

Idk but if you want levo-meth, look no further than otc levo Vick's inhalers. I prefer racemic.

 

[Eryximachus]

Like other metabolised prodrugs, abuse is much less of a problem.

Why?

 

[snmfmy]

Why?

Well for one the pro-drug usually doesn't have the same effect as the metabolite.

As an example, Deprenyl is an MAO-B inhibitor, not necessarily something you want to be taking large amounts of, that then metabolizes into a dopamine releaser.

And also metabolism takes time. Even if the pro-drug didn't have a negative effect profile compared to the wanted metabolite, it still takes the entire half-life to slowly metabolize (less than)half the pro-drug dose into the wanted drug.

Just imagine that You take a pro drug at 12:00 and by 9:00 p.m. half the dose that you wanted had been slowly infused into your body through metabolism. Not much of a rush and probably hardly any effects.