Damaging the transporter

[AiR-]

I read that by reversing the transporter it causes damage to the transporter , is this true?. (need source/or some backup please)

Some drugs reverse the transporter such as amphetamines.

And if reversing the transporter does cause damage to the transporter, is this not good?, because it can help prevent tolerance which is a huge issue...

 

[Seppi]

I read that by reversing the transporter it causes damage to the transporter , is this true?.

No. A few drugs that act as releasing agents by reversing monoamine neurotransmitter transporters do damage the axon terminal of monoamine neurons, like methamphetamine, but that's not true in general.

Transporter reversal is a physiological (i.e., normal/non-pathological) biological process that's mediated by kinase-dependent transporter phosphorylation. A number of endogenous biomolecules, like trace amines, trigger signaling cascades that activate certain protein kinases which phosphorylate membrane transport proteins in monoamine neurons, ultimately inducing transporter reversal as a consequence.