Hi ya'll!
So, I have read that the -azole class of antifungal drugs is an extremely potent CYP450 inhibitor, thus one would would think it therefore is an opiate potentiator. Even my pharmacist warned me of mixing this with my Rx oxy and highly recommended that I reduce my dosage as it increases blood concentration levels. This excited me in that my Rx allotment is extremely minimal and I already had been seeking out the best ways to stretch it as I do indeed have an unfortunate tolerance.
Tried this combo today, and much to my dismay, I actually felt a DECREASE in effects of my daily dosage (and if anything, only an increase in the not so fun side effects such as histamine and irritability). Needless to say, I'm not happy about this. I read somewhere on a forum that though CYP450 inhibitors may increase blood levels and leave the drug in your system longer - that they, on the other side, reduce the amounts of feel-good metabolites? Does anyone know anything about this? As a newbie to potentiators (I've only tried DXM thus far, which also didn't do shit), what should I try next?? I've read about Tagamet but it seems that operates on CYP450 as well? Is my body just weird? Kind of really determined to feel this stuff again without having to go through extreme measures to get more.
Thanks so much for any insight!!
(Note: it's straight oxy, no APAP)
So, I have read that the -azole class of antifungal drugs is an extremely potent CYP450 inhibitor, thus one would would think it therefore is an opiate potentiator. Even my pharmacist warned me of mixing this with my Rx oxy and highly recommended that I reduce my dosage as it increases blood concentration levels. This excited me in that my Rx allotment is extremely minimal and I already had been seeking out the best ways to stretch it as I do indeed have an unfortunate tolerance.
Tried this combo today, and much to my dismay, I actually felt a DECREASE in effects of my daily dosage (and if anything, only an increase in the not so fun side effects such as histamine and irritability). Needless to say, I'm not happy about this. I read somewhere on a forum that though CYP450 inhibitors may increase blood levels and leave the drug in your system longer - that they, on the other side, reduce the amounts of feel-good metabolites? Does anyone know anything about this? As a newbie to potentiators (I've only tried DXM thus far, which also didn't do shit), what should I try next?? I've read about Tagamet but it seems that operates on CYP450 as well? Is my body just weird? Kind of really determined to feel this stuff again without having to go through extreme measures to get more.
Thanks so much for any insight!!
(Note: it's straight oxy, no APAP)
