See, our dodgy advice, in the face of extreme situations, is really harm reduction. And some of us are dandies. No one ever said anything about harm elimination, that's Ms. Duggle's line of work.
I've had a feeling for a while, possibly just gas, that there's a bimodal harmful APAP dose. There's so much of this shit everywhere, that the sheer number of more routine, less-than-lethal overdoses of APAP are drowning out a special population that sees acute mortality closer to 2 grams.
I mean, imagine if 0.1% of the population has some kind of double rare SNP in APAPogenase, such that the all-by-itself, healthy-liver lethal APAP dose for half of them is 2 grams in one hour. That might get discovered a lot faster if people didn't routinely wash down 6 grams of APAP combo meds with more Nyquil.
But there is that occasional case report of someone keeling over after a gram. Sure, they're usually babies, so not really strapping adults. But how far-fetched is it for someone at Johnson&Johnson to compare a recall to deferred class-action costs, then recommend flooding the market with the murder weapon?
I know, the cost would be way less than they stood to make from just flooding the market with their product anyway. I'm serious about the bimodal toxic dose, though.
Dandy was a misprint, although someone who once knew ????? as Scrofula seems to prefer, did a presumably proper CWE on at least 20 generic loracet 10mg tablets,which had about 5/8ths of a gram of APAP per pop, so over a dozen grams, and they still ended up with too much Tylenol and eventually puked-he was a drinker, not alcoholic or anything(well not dependency) though still, it drives Jekly?s point in a way
750mg, is pretty close to the cutoff(well what cutoff that seems reasonable to me, though personally would prefer avoiding even that dose(1.5 of the modern day ?extra strength? tablets, or a single CR tablet, as they oddly have Tylenol Cr formulations now)
It was mainly directed towards people who insist on NSAID combo products, because they are afraid that less than a tablet or half a tablet is going to hurt they?re liver, when they admit to not having liver disease or even confirm any form of impairment
NAAPQI isn?t produced, or we are talking negligible amounts in subtheraputic doses, that?s all am really trying to say, and that Ibuprofen and others have thwy?re Own set of risks, and with Ibuprofen a gram is more likely to cause stomach bleeding vs a single gram of apap doing anything to the liver
CWE is fairly simple and with apap easy onceyou try and pick and try technique; of course Tylenol should be minimized, harm elimination isn?t possible- and Scrofula, if you don?t already know, the history of Tylenol?s toxic precursors and the discovery of ?safe? apap, twice, would drive you crazy- apap isn?t even a very good analgesic by non-narcotic standards, and has no anti-inflammatory properties, an anti-pyrrhic seems it?s main use-though people at some point need to be responsible and check ingredients and not combine apap containing products, of course the gov could actually regulate it, though that would make sense, so we can?t have that-like actually treating addicys, making needle exchanges and ORT widely available and affordable, we do that, and next thing ya know? they want freakin world peace. People and they?re wanting healthy livers-Like those pansexual non-aim stream religious people wanting equality. It?s insanity!!!!!!!!!!!!??!!!!!
