In a nutshell: does anyone know about this ? I know about the various axes like HPA, HPT, HPG, HPI (details unknown to me). Endocrinology is almost my hobby ...
Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104618/#__sec2title
(maybe some of you will like that article)
'Beta-endorphins are primarily synthesized and stored in the anterior pituitary gland2 from their precursor protein proopiomelanocortin (POMC). However, recent studies suggest cells of the immune system are also capable of beta-endorphin synthesis because immune cells possess mRNA transcripts for POMC3 and T-lymphocytes, B-lymphocytes, monocytes and macrophages have been shown to contain endorphins during inflammation.4–6POMC is a large protein that is cleaved into smaller proteins such as beta-endorphin, alpha-melanocyte stimulating hormone (MSH), adrenocorticotropin (ACTH), and others. The pituitary gland synthesizes POMC in response to a signal from the hypothalamus; that signal being corticotroponin-releasing hormone (CRH). The hypothalamus releases CRH in response to physiologic stressors such as pain, as in the postoperative period. When the protein products of POMC cleavage accumulate in excess, they turn hypothalamic CRH production off - that is, feedback inhibition occurs.'
Which could be why I get that setback one or two days after taking an opiate, which appears to resolve only after exercise. (As I mention in http://www.bluelight.org/vb/threads...(-)-have-given-me-a-sky-high-opiate-tolerance which may not really be due to clonazepam itself ?)
It appears that proopiomelanocortin is synthsized from pre-pro-opiomelanocortin (https://en.wikipedia.org/wiki/Proopiomelanocortin) but I was unable to find where that was synthesized from. Is there a formal 'axis' like HPA, HPT etc. ?
Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104618/#__sec2title
(maybe some of you will like that article)
'Beta-endorphins are primarily synthesized and stored in the anterior pituitary gland2 from their precursor protein proopiomelanocortin (POMC). However, recent studies suggest cells of the immune system are also capable of beta-endorphin synthesis because immune cells possess mRNA transcripts for POMC3 and T-lymphocytes, B-lymphocytes, monocytes and macrophages have been shown to contain endorphins during inflammation.4–6POMC is a large protein that is cleaved into smaller proteins such as beta-endorphin, alpha-melanocyte stimulating hormone (MSH), adrenocorticotropin (ACTH), and others. The pituitary gland synthesizes POMC in response to a signal from the hypothalamus; that signal being corticotroponin-releasing hormone (CRH). The hypothalamus releases CRH in response to physiologic stressors such as pain, as in the postoperative period. When the protein products of POMC cleavage accumulate in excess, they turn hypothalamic CRH production off - that is, feedback inhibition occurs.'
Which could be why I get that setback one or two days after taking an opiate, which appears to resolve only after exercise. (As I mention in http://www.bluelight.org/vb/threads...(-)-have-given-me-a-sky-high-opiate-tolerance which may not really be due to clonazepam itself ?)
It appears that proopiomelanocortin is synthsized from pre-pro-opiomelanocortin (https://en.wikipedia.org/wiki/Proopiomelanocortin) but I was unable to find where that was synthesized from. Is there a formal 'axis' like HPA, HPT etc. ?
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