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CONSCIOUSNESS

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Workbook on Psychedelic Integration focuses on life’s big questions

by Rachel Harris | LUCID News | 16 Sep 2021

Kile Ortigo, PhD is a psychologist with both a research and clinical background. This makes him an impressive guide as he invites you to travel with him across the landscape of existential exploration. Beyond the Narrow Life teems with conceptual diagrams, suggestions for personal discovery, exercises, journaling instructions, homework assignments and meditations. The author’s presence throughout the book is supportive and encouraging. Beyond the Narrow Life is a rich and complex guidebook which could keep a reader busy for…well…a lifetime of existential exploration.

The book promises to be a guide for psychedelic integration. It includes a three-page section on a “very brief overview of psychedelics,” as well as anonymous two-page trip reports toward the end of each chapter that are intended to illustrate “how a person might create meaning from and integrate the (psychedelic) experience in their life.” These are selected with therapeutic sensitivity and help connect the chapter content to psychedelic experiences, albeit minimally.

Given the current psychedelic renaissance and the burgeoning research studies documenting the therapeutic value of these medicines, psychedelic integration is a hot topic. However, it’s a topic that has not yet been well-defined, and this book does not contribute significantly to understanding how different psychedelic experiences can be integrated into one’s daily life. What does psychedelic integration mean after an ayahuasca ceremony versus after a ketamine trip? How is a psilocybin journey qualitatively different from one with MDMA when it comes to the challenge of learning from these experiences? These are questions for not only this author, but for the entire psychedelic community.

Our Western culture lacks a container that is both sacred and healing for the use of psychedelics. Oh, for a modern ritual like the Eleusinian Mysteries! We need to find new ways of working with these substances that lead naturally and seamlessly to bringing transformed individuals back into the community to share their transcendent gifts.


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The conceptual framework for the book is Joseph Campbell’s hero’s journey, first published in 1949. Simply put, it describes the departure, initiation and return. There are innumerable references to the Star Wars film series based on the same myth. Unfortunately, this outdated framework misses half the population. Maureen Murdock, in The Heroine’s Journey: Woman’s Quest for Wholeness, offers an alternative perspective for women that deals directly with the impact of the cultural patriarchy and considers the primacy of relationships in a woman’s life.

In a similar way, researchers have had to re-conceptualize psychological theories when they began to include women in their studies. Consider the evolution of the response to stress. For decades it was thought to be fight or flight; then eventually freeze was added as an alternative response. Then, lo and behold, researchers looked at how women actually respond and the framework had to be changed to include fight, flight, freeze, or tend and befriend.

Campbell’s hero’s journey is a rather lonely one, dedicated to self-evolution. Yet the daily challenge of psychedelic integration arises most frequently in relationships with loved ones. How do we behave when stressed, when hurt, when ignored or misunderstood? The hero’s journey shines little light on how moments of mystical experience evolve into kinder, more compassionate behavior in personal relationships, in the community and in the world.

As a guide for existential exploration, however, Beyond the Narrow Life offers a great variety of prompts for self-reflection. In essence, this is a workbook with exercises, suggestions, journaling activities and meditations. In this way, the book could serve as a rich adjunct to psychotherapy.

Each chapter opens with “Self-Reflections Check-In,” a paragraph of questions designed to explore what the reader learned, how they used the new insights in daily life and what’s opening up from within. “Did you start uncovering hidden parts of yourself? Which fears and concerns resonated with you? Whatever you experienced and discovered will continue to unfold.” These paragraphs are essential lessons in how to live an examined life. The author manages to communicate kindness and encouragement as he challenges the reader to self-reflect.

Intellectual content is presented with an abundance of graphs, charts, and figures selected to enhance the progression of the hero’s journey. Toward the end of each chapter there’s a list of possible suggestions designed to integrate into daily life what the reader has learned and discovered in themselves. For example, one suggestion is, “Outline your basic assumption about your life’s meaning.” Another one is, “Decide what your superpower might be if you were a superhero. Then imagine a ‘real world’ version of that power that you can develop, hone, or express in your life.”

These are creative, sophisticated suggestions with detailed, helpful examples to make them real. They reflect the author’s depth of clinical experience, working with clients over time in important ways.

Ortigo has a real interest in psychedelics — he completed the California Institute of Integral Studies (CIIS) program in Psychedelic-assisted Therapies and Research under the mentorship of Bill Richards, PhD, who wrote the Foreword for this book. He’s active on the board of Psychedelic Support, an online resource and directory for people seeking psychedelic informed care in legal, above-ground settings. The workbook suggestions in Beyond the Narrow Life are ideal for helping someone progress in a therapeutic process, but from this reader’s perspective they do not constitute a guide to psychedelic integration.

 
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Could consciousness all come down to the way things vibrate?

by Tam Hunt | The Conversation

A resonance theory of consciousness suggests that the way all matter vibrates, and the tendency for those vibrations to sync up, might be a way to answer the so-called ‘hard problem’ of consciousness.
Why is my awareness here, while yours is over there? Why is the universe split in two for each of us, into a subject and an infinity of objects? How is each of us our own center of experience, receiving information about the rest of the world out there? Why are some things conscious and others apparently not? Is a rat conscious? A gnat? A bacterium?

These questions are all aspects of the ancient “mind-body problem,” which asks, essentially: What is the relationship between mind and matter? It’s resisted a generally satisfying conclusion for thousands of years.

The mind-body problem enjoyed a major rebranding over the last two decades. Now it’s generally known as the “hard problem” of consciousness, after philosopher David Chalmers coined this term in a now classic paper and further explored it in his 1996 book, “The Conscious Mind: In Search of a Fundamental Theory.”

Chalmers thought the mind-body problem should be called “hard” in comparison to what, with tongue in cheek, he called the “easy” problems of neuroscience: How do neurons and the brain work at the physical level? Of course they’re not actually easy at all. But his point was that they’re relatively easy compared to the truly difficult problem of explaining how consciousness relates to matter.

Over the last decade, my colleague, University of California, Santa Barbara psychology professor Jonathan Schooler and I have developed what we call a “resonance theory of consciousness.” We suggest that resonance – another word for synchronized vibrations – is at the heart of not only human consciousness but also animal consciousness and of physical reality more generally. It sounds like something the hippies might have dreamed up – it’s all vibrations, man! – but stick with me.
All About the Vibrations

All things in our universe are constantly in motion, vibrating. Even objects that appear to be stationary are in fact vibrating, oscillating, resonating, at various frequencies. Resonance is a type of motion, characterized by oscillation between two states. And ultimately all matter is just vibrations of various underlying fields. As such, at every scale, all of nature vibrates.
Something interesting happens when different vibrating things come together: They will often start, after a little while, to vibrate together at the same frequency. They “sync up,” sometimes in ways that can seem mysterious. This is described as the phenomenon of spontaneous self-organization.
Mathematician Steven Strogatz provides various examples from physics, biology, chemistry and neuroscience to illustrate “sync” – his term for resonance – in his 2003 book “Sync: How Order Emerges from Chaos in the Universe, Nature, and Daily Life,” including:​
  • When fireflies of certain species come together in large gatherings, they start flashing in sync, in ways that can still seem a little mystifying.
  • Lasers are produced when photons of the same power and frequency sync up.
  • The moon’s rotation is exactly synced with its orbit around the Earth such that we always see the same face.
Examining resonance leads to potentially deep insights about the nature of consciousness and about the universe more generally.

Sync Inside Your Skull

Neuroscientists have identified sync in their research, too. Large-scale neuron firing occurs in human brains at measurable frequencies, with mammalian consciousness thought to be commonly associated with various kinds of neuronal sync.

For example, German neurophysiologist Pascal Fries has explored the ways in which various electrical patterns sync in the brain to produce different types of human consciousness.

Fries focuses on gamma, beta and theta waves. These labels refer to the speed of electrical oscillations in the brain, measured by electrodes placed on the outside of the skull. Groups of neurons produce these oscillations as they use electrochemical impulses to communicate with each other. It’s the speed and voltage of these signals that, when averaged, produce EEG waves that can be measured at signature cycles per second.

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Each type of synchronized activity is associated with certain types of brain function.

Gamma waves are associated with large-scale coordinated activities like perception, meditation or focused consciousness; beta with maximum brain activity or arousal; and theta with relaxation or daydreaming. These three wave types work together to produce, or at least facilitate, various types of human consciousness, according to Fries. But the exact relationship between electrical brain waves and consciousness is still very much up for debate.

Fries calls his concept “communication through coherence.” For him, it’s all about neuronal synchronization. Synchronization, in terms of shared electrical oscillation rates, allows for smooth communication between neurons and groups of neurons. Without this kind of synchronized coherence, inputs arrive at random phases of the neuron excitability cycle and are ineffective, or at least much less effective, in communication.

A Resonance Theory of Consciousness

Our resonance theory builds upon the work of Fries and many others, with a broader approach that can help to explain not only human and mammalian consciousness, but also consciousness more broadly.

Based on the observed behavior of the entities that surround us, from electrons to atoms to molecules, to bacteria to mice, bats, rats, and on, we suggest that all things may be viewed as at least a little conscious. This sounds strange at first blush, but “panpsychism” – the view that all matter has some associated consciousness – is an increasingly accepted position with respect to the nature of consciousness.

The panpsychist argues that consciousness did not emerge at some point during evolution. Rather, it’s always associated with matter and vice versa – they’re two sides of the same coin. But the large majority of the mind associated with the various types of matter in our universe is extremely rudimentary. An electron or an atom, for example, enjoys just a tiny amount of consciousness. But as matter becomes more interconnected and rich, so does the mind, and vice versa, according to this way of thinking.

Biological organisms can quickly exchange information through various biophysical pathways, both electrical and electrochemical. Non-biological structures can only exchange information internally using heat/thermal pathways – much slower and far less rich in information in comparison. Living things leverage their speedier information flows into larger-scale consciousness than what would occur in similar-size things like boulders or piles of sand, for example. There’s much greater internal connection and thus far more “going on” in biological structures than in a boulder or a pile of sand.

Under our approach, boulders and piles of sand are “mere aggregates,” just collections of highly rudimentary conscious entities at the atomic or molecular level only. That’s in contrast to what happens in biological life forms where the combinations of these micro-conscious entities together create a higher level macro-conscious entity. For us, this combination process is the hallmark of biological life.

The central thesis of our approach is this: the particular linkages that allow for large-scale consciousness – like those humans and other mammals enjoy – result from a shared resonance among many smaller constituents. The speed of the resonant waves that are present is the limiting factor that determines the size of each conscious entity in each moment.

As a particular shared resonance expands to more and more constituents, the new conscious entity that results from this resonance and combination grows larger and more complex. So the shared resonance in a human brain that achieves gamma synchrony, for example, includes a far larger number of neurons and neuronal connections than is the case for beta or theta rhythms alone.

What about larger inter-organism resonance like the cloud of fireflies with their little lights flashing in sync? Researchers think their bioluminescent resonance arises due to internal biological oscillators that automatically result in each firefly syncing up with its neighbors.

Is this group of fireflies enjoying a higher level of group consciousness? Probably not, since we can explain the phenomenon without recourse to any intelligence or consciousness. But in biological structures with the right kind of information pathways and processing power, these tendencies toward self-organization can and often do produce larger-scale conscious entities.

Our resonance theory of consciousness attempts to provide a unified framework that includes neuroscience, as well as more fundamental questions of neurobiology and biophysics, and also the philosophy of mind. It gets to the heart of the differences that matter when it comes to consciousness and the evolution of physical systems.

It is all about vibrations, but it’s also about the type of vibrations and, most importantly, about shared vibrations.

Tam Hunt is an Affiliate Guest in Psychology at the University of California, Santa Barbara.

 
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Documentary on consciousness explores territory where words fail

by Don Lattin | LUCID News | 23 Sep 2021

There’s nothing like a high-dose trip on magic mushrooms, ketamine or 5-MeO-DMT to get one wondering about this thing we call “consciousness.”

What is it? Where is it? And why is it so hard to retain, explain and learn from the insights these drugs reveal once we return to our old patterns of thinking?

When we transcend our skin-encapsulated egos and connect in new ways to a power greater than ourselves, what is that force we perceive? Is it God, a delusion or something in between? Is this a “higher self” or a “true self” or is it all just a mental projection? Is this all inside our heads, or are we tuning into some cosmic reality?

For more years than I care to admit, I’ve tried to write about altered states of consciousness as a journalist — first for a daily newspaper in San Francisco and more recently as the author of three books on the psychedelic renaissance.

Words can only take us so far when we try to write about the ineffable.

So it was with all this in mind that I watched a preview of a wondrous new documentary film, Aware — Glimpses of Consciousness, by directors Frauke Sandig and Eric Black.

Not only do words fail. It’s notoriously difficult to visually depict a psychedelic state of mind on film. Sandig and Black do so in subtle but powerful ways. Not with cheesy special effects, but with mystical footage of the cosmic dance between sea and sky, forests and ferns, birds and bees, all over an evocative soundtrack that could be sampled to enliven any psychonaunt’s playlist.


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Profiled in Aware are six of the world’s leading researchers into the nature of our minds and how they connect us to the larger world. Some approach the consciousness conundrum as scientists, others as spiritual teachers. Some employ psychedelics. Some don’t. But there’s a revealing continuity to their insights. Both the scientists and the spiritualists in this film remain open to the many mysteries of the human mind.

The film features Richard Boothby, a professor of philosophy at Loyola University; Monica Gagliano, a professor of plant behavior and cognition at the University of Sydney; Roland Griffiths, director of the Center for Psychedelic and Consciousness Research at Johns Hopkins University; Josefa Kirvin Kulix, a Mayan healer from Chiapas, Mexico; Christof Koch, director of the Allen Institute for Brain Science in Seattle; and Matthieu Ricard, a French-born Tibetan Buddhist monk at Shechen Monastery in Tibet.

Some of the most fascinating scenes focus on Gagliano, whose scientific research seems to indicate that plants are able to hear, see, communicate, learn, remember and feel pain. This is one of those ideas that is hard to believe until you lay in a field of flowers after ingesting 300 micrograms of LSD. Now we have the proof.

Boothby, the philosophy professor, called himself an atheist until he had a five-hour psilocybin session at Roland Griffiths’ lab Johns Hopkins. Now he has no trouble using the word “divine” when describing how he felt “the heartbeat of reality itself.”

Griffiths, whom I profile in my 2017 book Changing Our Minds — Psychedelic Sacraments and the New Psychotherapy, notes that meditation can slowly allow us to access a larger reality than our workaday ego-centric selves. “Psilocybin is the crash course,” he adds with a laugh.


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For those who’d rather skip the drugs, Ricard offers tips on how Buddhist meditation can allow a glimpse of a “pure awareness at the depth of consciousness.” He and Griffiths, the monk and the scientist, agree that the trick is to “become aware of being aware.”

Griffiths notes that no matter how we get there, via meditation or psychedelics, the important thing is to change the way we treat each other and the natural world.

Sandig and Black agree.

“This is not just a case of ancient wisdom versus modern science,” they state in their directors’ statement. “Consciousness is political. Defining consciousness is the most invisible yet most powerful form of political control. The idea of separateness has turned the rest of our world – oceans, forests, animals, plants and other people and perhaps ourselves – into objects, leading to overwhelming crises, from racial mania and ethnic conflict to the exploitation of ‘natural resources’ and the climate catastrophe.”

All the recent advances in high-tech imagining, brain dissection, computer modeling and the other tools of neuroscience have raised as many questions as answers when it comes to understanding the true nature of human consciousness.

And that’s okay.

There is awe and wonder coming from all the “experts” interviewed in Aware, whether they are scientists or mystics. In the end, this is a hopeful film, and God knows we could all use some of that right now.

Aware: Glimpses of Consciousness opens this Friday (September 24, 2021) at theaters in San Francisco, Los Angeles and San Rafael, and on October 8 in New York City. For the complete theatrical schedule and other information, visit the website.

 
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Exploring Consciousness with Psychedelics

by Tiffany Quinn | Technology Networks

Psychedelics (from the Greek psyche: mind, delos: reveal), believed to be the oldest class of psychopharmacological agents in recorded history, are potent psychoactive substances known for their ability to induce a heightened state of consciousness in users. Over the years, controversy surrounding their effects has made investigations into the science of psychedelics difficult, however scientists have been regaining an interest in their action within the brain and the implications.

On Saturday 22nd September, Chris Timmermann - a neuroscience PhD candidate from Imperial College London (ICL) - delivered a fascinating presentation at the New Scientist Live festival in London on the use of psychedelics to study consciousness. Over at the Humans stage, Timmermann set the scene by exploring the longstanding use of classic psychedelics (ayahuasca, magic mushrooms, San Pedro and peyote) by individuals in Africa, America and Siberia for medicinal and ceremonial purposes. “Experiences occur below the threshold of consciousness” explained Timmerman, therefore when we take psychedelics we “call upon our consciousness”, which usually results in a feeling of “deep immersion with reality or a different dimension”. Hallucinations, bodily effects and the perception of unworldly entities are other commonly reported effects. Despite centuries of literature documenting psychedelic experiences, our understanding of what is happening in the human brain, at a fundamental level, has been less apparent. Until now.

N, N-Dimethyltryptamine, better known as DMT, is found in ayahuasca and is believed to be the most potent psychedelic compound, creating “an axis to a different dimension” explained Timmermann. To better understand its effects on the brain, his colleagues at ICL have been investigating the effects of intravenous injections in 13 human volunteers under controlled conditions in their lab. During the single-blind placebo-controlled study all participants received the placebo on day one followed by DMT on day two. Crucially, to eliminate subject bias, they were not told which drug they would receive before each session.

Timmermann showed drawings produced after the experiments by those who had received DMT depicting complex, vibrant scenes that had been described by participants as a “world analog” or “dreamworld”. Additionally, a significant overlap was found between the DMT-induced experience and near-death experiences (NDEs). Most participants recall the presence of other beings, out of body experiences and an ego-dissolution, all of which are commonly reported in NDEs. Interestingly, Timmermann added that participants with certain personality traits such as neuroticism or strong religious and/or mystical beliefs were more likely to recall these NDE-like experiences. He went on to suggest that contextual factors such as personality or a propensity towards delusionary thinking can greatly influence the quality and intensity of DMT-induced NDE-like experiences.

Although one can argue that knowledge of these psychological effects is not new, the information that electroencephalography (EEG) recordings revealed to Timmerman and his team, just might be.

How does DMT affect brain activity?

EEG is a non-invasive approach involving the positioning of electrodes on the scalp to measure and record the electrical activity that is generated from neuronal communication in the brain. Neuroscientists investigating consciousness typically use EEGs to study these brainwaves during altered states of consciousness as they provide insights into changes in brain activity.

Our conscious active brain, is dominated by highly active beta and gamma waves. When we are relaxed - but not asleep - alpha waves predominate. As we become drowsy and fall asleep theta and delta waves become more active (notably, these brain waves are associated with dreaming).


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The different frequencies of recordable human brain waves .
Credit: M. Roohi-Azizi, et al., 2017.


Broadly speaking, Timmermann and his team discovered that all rhythms were dampened during the DMT-induced psychedelic experience. This effect was however, more noticeable for alpha wave activity. Since activation of alpha waves is thought to represent “active disengagement from the environment,” their dampening during a DMT trip was used to support the claims made by participants that they were significantly more engaged with the environment on DMT. Timmermann suggests that increased disorganization within the brain, may be responsible for this detachment from the self and the resulting “unity” with the world. Furthermore, having asked the volunteers to monitor the intensity of their experience throughout the experiment, the researchers found a significant correlation between increased activation of delta and gamma waves and periods of the highest intensity. Similar to what occurs in the brain whilst we are in a dream-state.

The overwhelming peace and euphoria that results from the DMT experience, supported by Timmerman’s study has been used to suggest its potential as a treatment for anxiety and depression. Whilst more research certainly needs to be done, Timmermann’s presentation successfully demonstrated how psychedelics are beginning to shift our understanding of the mechanisms underlying altered states of consciousness and their implications.

To find out more about Chris Timmerman and his research visit: https://www.imperial.ac.uk/department-of-medicine/research/brain-sciences/psychiatry/psychedelics/

 
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The Relationship Between Psychedelics and Consciousness

Johns Hopkins Medicine | Neuroscience News | 31 Mar 2022

The study found that among people who had had a single psychedelic experience that altered their beliefs in some way, there were large increases in attribution of consciousness to a range of animate and inanimate things.

Psychedelic drugs like psilocybin, an ingredient found in so-called magic mushrooms, have shown promise in treating a range of addictions and mental health disorders. Yet, there’s something mysterious and almost mystical about their effects, and they are commonly believed to provide unique insights into the nature of consciousness.

Now, a new study by Johns Hopkins Medicine researchers addresses the question of whether psychedelics might change the attribution of consciousness to a range of living and nonliving things.

The findings, published March 28 in Frontiers in Psychology, reveal that higher ratings of mystical type experiences, which often include a sense that everything is alive, were associated with greater increases in the attribution of consciousness.

“This study demonstrates that when beliefs change following a psychedelic experience, attributions of consciousness to various entities tend to increase,” says Sandeep Nayak, M.D., postdoctoral research fellow at the Johns Hopkins Center for Psychedelic and Consciousness Research and one of the researchers involved in the study.

“It’s not clear why, whether that might be an innate drug effect, cultural factors, or whether psychedelics might somehow expose innate cognitive biases that attribute features of the mind to the world.”

For the study, the researchers analyzed data gathered between August 2020 and January 2021 on 1,606 people who had had a belief-changing psychedelic experience. Participants averaged 35 years of age and were predominately white (89 percent), male (67 percent) and from the United States (69 percent).

Study participants completed an internet-based survey that included questions focused on belief changes attributed to a single psychedelic experience with a classic psychedelic substance (e.g., psilocybin mushrooms, LSD, ayahuasca). The survey also included questions about demographics, psychedelic use, personality, and scientific knowledge and attitudes.

The study found that among people who had had a single psychedelic experience that altered their beliefs in some way, there were large increases in attribution of consciousness to a range of animate and inanimate things.

For example, from before to after the experience, attribution of consciousness to insects grew from 33% to 57%, to fungi from 21% to 56%, to plants from 26% to 61%, to inanimate natural objects from 8% to 26% and to inanimate manmade objects from 3% to 15%.

“On average, participants indicated the belief-changing experience in question occurred eight years prior to taking the survey, so these belief changes may be long-lasting,” says Nayak.

Classic psychedelics—the pharmacological class of compounds that includes psilocybin and LSD—produce visual and auditory illusions and profound changes in consciousness, altering a person’s awareness of their surroundings and of their thoughts and feelings.

These substances produce unusual and compelling changes in conscious experience, which have prompted some to propose that psychedelics may provide unique insights into the nature of consciousness itself.

“The results suggesting that a single psychedelic experience can produce a broad increase in attribution of consciousness to other things, raises intriguing questions about possible innate or experiential mechanisms underlying such belief changes,” says Roland Griffiths, Ph.D., the Oliver Lee McCabe III, Ph.D., Professor in the Neuropsychopharmacology of Consciousness at the Johns Hopkins University School of Medicine, and founding director of the Johns Hopkins Center for Psychedelic and Consciousness Research.

“The topic of consciousness is a notoriously difficult scientific problem that has led many to conclude it is not solvable.”

 
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How Psychedelics Alter Our Consciousness

by Benjamin Taub | IFL SCIENCE | 21 Dec 2021

The term "psychedelic" is derived from the Ancient Greek words "psyche" (meaning "mind") and "delos" (which means "to manifest"), coined by a psychiatrist named Humphrey Osmond in a letter sent to the famous author Aldous Huxley in 1956. Writing about the merits and pitfalls of LSD and mescaline, Osmond came up with the rhyming couplet: “to fathom hell or soar angelic, just take a pinch of psychedelic.”

By this, he meant that certain substances have the potential to expose and activate hidden layers of consciousness, triggering experiences that can range from the diabolical to the sublime. Over half a century later, scientists are finally putting psychedelics under the microscope in an attempt to reveal how they generate these surreal phrenic odysseys.

Losing the self

Poetic though they may be, outcomes like fathoming hell or soaring angelic are difficult to define scientifically. This is why researchers have developed a tool called the Five-Dimensional Altered States of Consciousness (5D-ASC) Rating Scale to help categorize psychedelic experiences. The scale measures aspects such as “oceanic boundlessness”, a feeling of being indistinct from one’s surroundings, plus a more general loss of the sense of self, referred to as “ego-dissolution.”

Exactly how a psychedelic “pinch” transports one’s consciousness down the 5D-ASC rabbit hole is not yet fully understood, although we do know that it all hinges on a particular type of serotonin receptor called 5-HT2A. Numerous studies have revealed that psychedelics like LSD, psilocybin, and ayahuasca exert their mind-altering effects by activating this receptor, and chemically blocking 5-HT2A binding sites appears to nullify the potency of these substances.

For instance, one study found that giving people LSD caused a blurring of the perceived boundaries between themselves and others, but that this could be avoided by deactivating their 5-HT2A receptors using a compound called ketanserin. Dr Matthew Johnson, professor of psychiatry and behavioral sciences at Johns Hopkins University, told IFLScience that this sense of ego-dissolution is a hallmark of “mystical experiences”, which some researchers believe are key to the healing potential of psychedelics.

“The real tell-tale, or at least the most impressive feature of a mystical experience, is having this notion of oneness where the sense of subject and object break down,” he said. One of the world’s most published scientists on the effects of psychedelics, Johnson went on to explain that "this phenomenon occurs when psychedelic drugs loosen the self-narrative by temporarily disrupting the neurological blueprint for one’s own identity."

An archetypal reaction to psychedelic drugs, mystical experiences are categorized using the Mystical Experience Questionnaire (MEQ), which measures such things as a “feeling that you experienced eternity or infinity” and “the insight that 'all is One'.” How one little receptor can generate such grandiose shifts in consciousness is something that researchers are slowly beginning to understand.

The ego in the brain

Once a compound hits up your 5-HT2As, a psychedelic signature pattern of brain activity begins to emerge – the complexities of which have not yet been fully comprehended. In general terms, Johnson explains that “there are drastic changes to network communication in the brain, and it’s probably the case that these underlie all kinds of experiences, both positive and negative.”

More specifically, the default mode network (DMN), containing numerous structures involved in self-referential processing, has been found to disintegrate under psychedelics, meaning that the connectivity patterns that hold this network together become weakened.

This mechanism was initially revealed in 2016 when researchers published the first brain scans under the effects of LSD, leading to the idea that many aspects of psychedelic experiences, including ego-dissolution, are largely mediated by the DMN. As Johnson explains, “when someone has a greater sense of oneness or ego-loss there is more decoupling of the default mode network, so that seems to be playing some part in generating these effects.”

“However, a caveat to that is that other drugs like alcohol and amphetamine have also been shown to decouple the default mode network, which introduces a bit of a monkey wrench into the idea that this decoupling is the quintessential or critical feature of a psychedelic,”
he says. “There are other changes in brain network synchronization that appear to be involved and I think we need more work in that area to figure out what’s really going on.”
The entropic brain

Under psychedelics, the neat patterns of connectivity that hold brain networks in place and keep them distinct from one another break down. Simultaneously, a riotous increase in communication occurs throughout the brain as regions that don’t normally interact suddenly become connected. The resultant neurological mayhem is sometimes referred to as an “entropic” brain state, and is responsible for the dizzying and unpredictable nature of psychedelic trips.

For instance, dropping acid causes the visual cortex to start linking up with other brain regions that normally have nothing to do with vision, which may explain the bizarre visual hallucinations that people often experience while tripping. More specifically, the parahippocampus, which processes autobiographical memories, has been found to communicate with the visual cortex under LSD, possibly causing figments of one’s imagination and memories to dance before one’s eyes.

“There is some evidence that psychedelics increase access to autobiographical memories, so they may make certain unconscious material more readily available to conscious awareness,” says Johnson. Fascinatingly, the LSD-induced increase in communication between the parahippocampus and visual cortex appears to be amplified by music, highlighting the massive role that auditory stimuli play in influencing psychedelic experiences.

Having said that, not all trips involve visuals. The psychedelic compound 5-MeO-DMT, found in the secretions of the Colorado River toad, is said to trigger intense mystical experiences that often lack any visual content whatsoever, instead leaving users with a sense of having entered an existential “void”. Then again, the phenomena generated by these substances tend to vary greatly between individuals, and it’s impossible to say exactly how any given person will be affected by a particular psychedelic drug.

Ultimately, the aesthetic details of psychedelic experiences are wildly unpredictable, making it difficult to pinpoint a defining quality that is common to all trips. If there is a thread that links these experiences, it can be found in the fact that they all arise from an entropic form of cognition which, according to Johnson, “allows for more possibilities by creating a more chaotic, less predictable state of consciousness.”

Is this reality?

Cerebral chaos may not sound like a particularly useful characteristic, but some researchers believe that the tripping brain actually represents a “higher level of consciousness” than our typical, sober state. By expanding the range of possible configurations of brain activity, these curious drugs may in fact unshackle us from the limits of regular consciousness, thus providing access to novel insights and ideas. They may even enable us to catch a glimpse of objective reality, rather than the filtered and restricted version that our brains conveniently present to us.

“What we experience most of the time is not raw, ground truth reality,” says Johnson. “It’s a billion years of evolution processing reality in a particular way that’s allowed us to survive and reproduce.”

For example, he says that “it’s not necessarily inherent in the universe that one should have a sense of self, or that different things should have their own self-identities. Yet all of our problems and all of our experiences, they’re all derivative of that sense of self.”

By disrupting the neurological scaffolding that holds this notion of individual identity in place, psychedelics allow us to experience the world from a perspective that is less constrained by our natural, self-centered system of consciousness. According to Johnson, the opportunity to step outside of this formatted version of reality is in itself hugely liberating and enlightening.

“You realize that your sense of self is an illusion, or at least the concrete form of it that you’ve gotten used to is just a model that you’ve created,” he says. “That gives you more of a flexibility to move and be less constrained by it.”

Thus, by shining a light on the tricks our consciousness plays on us in order to help us navigate the world, psychedelics may one day be used not only to alleviate mental anguish, but to deepen our appreciation of our own nature. Asked for his assessment of the ultimate potential of these fascinating compounds, Johnson replies: “I think in the biggest picture, beyond the treatment of disorders, they can be used as tools to understand the brain and mind.”

In other words, psychedelics do a pretty good job of living up to the literal translation of their name.

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Benjamin Taub

 
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Psychedelics and Consciousness
Distinctions, Demarcations, and Opportunities


David B. Yaden , Matthew W. Johnson, Roland R. Griffiths, Manoj K. Doss, Albert Garcia-Romeu, Sandeep Nayak, Natalie Gukasyan, Brian N. Mathur, Frederick S. Barrett

Johns Hopkins and University of Maryland | Oxford University Press | 4 Apr 2021

Psychedelic substances produce unusual and compelling changes in conscious experience that have prompted some to propose that psychedelics may provide unique insights explaining the nature of consciousness. At present, psychedelics, like other current scientific tools and methods, seem unlikely to provide information relevant to the so-called “hard problem of consciousness,” which involves explaining how first-person experience can emerge. However, psychedelics bear on multiple “easy problems of consciousness,” which involve relations between subjectivity, brain function, and behavior. In this review, we discuss common meanings of the term “consciousness” when used with regard to psychedelics and consider some models of the effects of psychedelics on the brain that have also been associated with explanatory claims about consciousness. We conclude by calling for epistemic humility regarding the potential for psychedelic research to aid in explaining the hard problem of consciousness while pointing to ways in which psychedelics may advance the study of many specific aspects of consciousness.
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The resurgence of psychedelic research has provided tools for researchers who study mental processes such as perception, affect, and cognition (Johnson et al., 2019). Beyond these routine subjects of scientific inquiry for the brain and cognitive sciences, some have expressed hopes that psychedelics may somehow help to explain consciousness (e.g., the sub-title of Michael Pollan’s bestselling book on psychedelics begins, “What the New Science of Psychedelics Teaches Us About Consciousness...” Even the term “psychedelic” itself refers to consciousness, as it comes from the Greek for “mind”—psyche (ψυχή)—and “manifesting”—delic (δηλείν). By consciousness here, in the broadest possible sense before introducing further distinctions, we mean to refer to the mental state of basic subjective awareness or first-person experience (or the “what it is like” to be a system or organism) that, for example, occurs after one awakens from the lack of consciousness of deep sleep or anesthesia.

Psychedelic substances produce unusual and compelling changes in conscious experience that have prompted some to propose that psychedelics may provide unique insights into the nature of consciousness. While psychedelics can and are being used to study their effects on consciousness (or more precisely, on the contents of consciousness), the idea that psychedelics can and are being used to explain the hard problem of consciousness (defined below) is quite another matter. Here, we argue that the relationship between psychedelics and consciousness hinges on what is meant by the term “consciousness,” which researchers tend to use in different ways at different times). As Johnson argues, more care is required regarding the use of the term consciousness, particularly among those who study psychedelics. Here we describe issues at the intersection between psychedelics and different senses of the term consciousness and conclude by calling for high levels of epistemic humility around the potential for psychedelics to aid in explaining consciousness, while pointing to some specific senses of the term consciousness that psychedelic research may help to illuminate.

The hard and easy Problems of Consciousness

The philosophical concepts of the “hard problem” and the “easy problem(s)” of consciousness are among the most basic distinctions––a debate with historical roots that remains a lively contemporary discourse. The hard problem of consciousness refers to explaining what phenomenal consciousness is and how it comes to be. Phenomenal consciousness can be defined as the first person subjective “what it is like” to be an organism; these subjective sensations are also referred to as “qualia." In this sense, the hard problem is concerned with explaining what the immediate, subjective experience of being (i.e., phenomenal consciousness) is and how it relates to objectively observable phenomena such as brain activity and behavior. The hard problem of consciousness is currently not scientifically answered, and it is not clear that a scientific answer is even possible, which is why it is called “a hard problem.” For this reason, the hard problem is often described in terms of the “explanatory gap." This phrase may be an understatement––there is far more than a gap, but rather a yawning chasm between our current scientific understanding and the prospect of explaining the hard problem of consciousness. At present, there is little reason to think that psychedelics will bring us any closer to closing the explanatory gap.

In contrast, the so-called “easy problems” of consciousness consist of a variety of distinct problems that are plausibly explainable (e.g., how attention, perception, and the deliberate control of behavior work). One common example of an easy problem (which in actual fact is quite a difficult scientific subject) is explaining how light on the retina is eventually perceived in the visual field. Even if they are not currently explained, it seems clear that these and related questions can possibly be explained to some degree or in some mechanistic fashion through current scientific methods given sufficient time and effort. Understanding these mental processes involves describing the contents of consciousness. In contrast to the hard problem, psychedelic research may be brought to bear on some of the “easy problems.”

One of the many reasons that the hard problem of consciousness is difficult (or maybe impossible) to scientifically address is that phenomenal consciousness cannot be observed directly by anyone other than a given conscious entity. This is referred to as “the problem of other minds." To illustrate, the reader knows that she or he is conscious, but cannot be certain that anyone else is conscious. Strictly speaking, the best one can do is infer consciousness in others on the basis that others seem to be similar kinds of beings as oneself. This poses serious problems for the scientific method regarding consciousness. Even if it were possible to engineer the creation of consciousness (e.g., with artificial intelligence), it is unclear how one could prove whether consciousness had indeed been created. One could ask another entity if it were conscious (e.g., an artificial intelligence), but there would be no way to verify its self-report. Block distinguished between “access consciousness,” which involves the availability of information and ability to use it in reasoning processes, and “phenomenal consciousness” (introduced in the previous paragraph), which involves the feeling quality of being aware. One could establish, for example, whether an artificial intelligence has access consciousness (e.g. via some form of the Turing test), but could not establish whether an artificial intelligence has phenomenal consciousness. The identical problem of verifiability presents itself when attempting to assess consciousness in another person. Some of these issues extend to the study of the psychological processes that consist of the contents of consciousness and, by extension, the various easy problems of consciousness, at least insofar as subjective access to the content of one’s consciousness remains private. However, a difference is that the contents of consciousness (thoughts, emotions, perceptions, etc.) can be caused and manipulated to some extent within other people, and these changes can be more directly reported and measured, whereas phenomenal consciousness itself cannot be caused or so clearly operationally observed in this manner (and its causation cannot be verified).

While there is no current scientific explanation of phenomenal consciousness, there are a number of philosophical theories about its nature. These theories can be grouped into 3 broad categories: materialist, dualistic, and monistic. Materialist theories, favored by many scientists, regard phenomenal consciousness as identical to brain states. However, materialists would need to explain how physical processes (e.g., the brain) give rise to “qualia,” the “what it feels like” quality of being conscious, or how subjective experience arises from interaction of material entities (e.g., atoms, neurons) that presumably do not possess such phenomenal consciousness themselves. Some see the problem of qualia (and indeed the whole notion of the hard problem) as a pseudoproblem, arguing that there is nothing to explain, while others see this dismissal as ignoring the fundamental phenomena. Dualistic theories consider phenomenal consciousness as distinct from matter (i.e., that phenomenal consciousness is essentially different from matter and brain states, though these may interact in ways yet to be precisely determined). Dualistic theories would need to explain what evidence there is for this perspective (beyond intuitions) as well as how something non-physical (i.e., consciousness) could interact with physical matter (e.g., the brain), and how this can be ascertained (or falsified) empirically. Monistic views such as neutral monism conceive of phenomenal consciousness and matter as part of the same basic stuff, which is neither inherently matter nor mind. This view is often associated with a view called panpsychism, which posits that all matter (not just brains) is in some way conscious. Due to the issues such as those related to verifiability, it is not clear to us that psychedelics can inform challenges posed by each of the philosophical theories about the nature of consciousness––at least at present. Psychedelics may, though, impact beliefs about these different theories of phenomenal consciousness under some circumstances, which we will return to later in this review.

Scientists tend to ignore the hard problem of consciousness and generally adopt methodological materialism to address the easy problems of consciousness. This is the principal domain of research of many scientific disciplines (e.g., psychology, cognitive science, neuroscience, and psychopharmacology). Thus, the term “consciousness” is sometimes used to refer to the wide array of the contents of the mind in general (e.g., perceptions, thoughts, feelings, and emotions). This all-inclusive use of the term consciousness is so broad, referring to all of aspects of the contents of consciousness within the range of scientific inquiry in psychology and neuroscience, that it has limited use.

There are a few scientific theories that attempt to explain how phenomenal consciousness appears unitary (perceptual, cognitive, and affective processes appear seamlessly integrated) in terms of neural correlates, a problem referred to as the neural correlates of consciousness. The global workspace theory of consciousness focuses on how disparate mental processes combine to create the unitary “cinematic” quality of conscious experience. The integrated information theory of consciousness defines consciousness in terms of the level of complexity of ordered information and attempts to operationalize this with Φ (“phi”). Although it would be interesting to investigate how psychedelic states relate to Φ, it is not clear how this would improve our understanding of the hard problem of consciousness. For example, relatively simple digital logic gates (e.g., XOR gate), which intuitively seem non-conscious, can generate large amounts of Φ. It is also not clear that the assertion of complexity itself being a measure of consciousness is tenable. Increasing or decreasing Φ or dissecting and understanding the global workspace would not explain how physical processes give rise to qualia, and though testing psychedelics in these paradigms may be interesting, psychedelics do not appear to bear on these deeper issues.

Neuroscientific Models of Psychedelics and their Impact on Understanding Consciousness

Despite the foregoing issues with addressing the hard problem of consciousness, or explaining phenomenal consciousness, some have claimed that neurological theories or models of psychedelic effects might illuminate the subject of phenomenal consciousness. We briefly review 3 popular theories or models of this kind describing the proposed role of psychedelics and noting claims portending that these theories or models may explain how phenomenal consciousness arises from the brain. While it is unclear how any of these models could provide information relevant to the hard problem, each of them do generate interesting predictions regarding various easy problems of consciousness that are scientifically tractable.

Relaxed beliefs under psychedelics (REBUS) was proposed as a “unifying model” of the effects of psychedelics on brain function that attempts to explain their subjective effects. The REBUS model largely relies on the free energy principle, which claims that living systems (technically, any system that possesses a boundary called a Markov blanket) seek to reduce uncertainty and do this largely through predictive processes. REBUS purportedly integrates FEP with the “entropic brain hypothesis", which proposes that levels of entropy (disorder or randomness) in brain function will correlate with the subjective diversity and vividness of a given subjective state. According to the entropic brain hypothesis, psychedelics increase brain entropy and therefore result in more diversity and vividness in subjective awareness. The REBUS theory proposes a specific role of increased entropy and decreased “top-down” control of the default mode network (DMN) as central to psychedelic drug effects on the contents of consciousness, such as perceptual alterations. REBUS is slightly more precise than the entropic brain hypothesis insofar as it specifies the primary locus of entropy that is impacted by psychedelics, which is in the “precision weighting of prior beliefs encoded in the spontaneous activity of neuronal hierarchies,” primarily in the DMN. REBUS proposes that a relaxation of top-down priors allows bottom-up information to exert more influence in brain function, learning, and perception. In regard to explaining phenomenal consciousness, it has been claimed that through prediction errors of interoceptive processes, FEP can “explain the “‘how and why’ it feels like something within the system, for the system." That is, this model seeks to explain the effects of psychedelics, and at least part of it has been postulated as a way to explain phenomenal consciousness.

Support for the entropic brain hypothesis includes increases in some measures of entropy in neuroimaging data during the acute effects of psychedelics, although we note that these findings must be considered preliminary due to the small sample size of the 2 studies that form the basis for many of these speculations. Furthermore, entropy has been inferred or calculated in many different ways; these include a decrease in synchronization of high-frequency electrical or magnetic oscillations recorded at the scalp, Shannon’s entropy in node-wise or edge-wise (other) variance of low-frequency fluctuations in blood oxygenation level–dependent signal, or entropy of dynamic functional connectivity. Müller et al. has reported similar fMRI connectivity changes after administration of a selective serotonin reuptake inhibitor (SSRI), MDMA, and classic psychedelics, which raises questions regarding the specificity of these findings to classic psychedelics. Rather than providing broad conceptual replications of increased brain entropy during psychedelic states, these very different measures may instead reflect different sources of signal and noise and, therefore, potentially implicate distinct systems-level neural mechanisms. Thus, it is unclear whether these various measures provide support, or even properly test, the hypothesis that entropy causally mediates the diversity or vividness of any given subjective state.

Some observations appear to count against the REBUS model. For example, if psychedelics decrease prediction capacity, then surprise (or more technically, prediction errors) should increase, but evidence for this has been mixed. The wide, nearly non-specific reporting of changes in entropy across various measures of brain function parallels a lack of specificity in what constitutes “top-down”/higher or “bottom-up”/lower levels of brain functioning. Counter to any account of decreased top-down control of bottom-up information, LSD has been shown to increase information flow from the parahippocampal gyrus (which in this example would be nearly unequivocally higher level) to visual cortex (which in this example would be nearly unequivocally lower level). The specificity of the DMN in neural effects of psychedelics is also in question, as nearly all reports of DMN changes under psychedelics also report equal or greater changes in taskpositive functional brain networks. REBUS seems to provide a hypothesis (e.g., entropic brain) and some grounding to concepts expressed in the free energy principle. One proposed implication of the REBUS model is that psychedelics might be efficacious in the treatment of disorders of consciousness, that is, vegetative and minimally conscious states secondary to acquired brain injury. Scott and Carhart Harris highlight that brain complexity (e.g., measured by Lempel-Ziv compressibility) is positively correlated with states of awareness and they suggest that psychedelic-induced increases in brain complexity may restore or improve awareness in patients with disorders of consciousness (to date, no studies on the effects of psychedelics in this population have been completed). It also appears possible that REBUS may help to explain changes to one’s sense of self-awareness, but self-awareness and related changes in subjectivity remain well within the bounds of the easy problem of consciousness. REBUS thus generates interesting hypotheses to test but little to no hope for gaining traction on the hard problem.

The cortico–striato–thalamo–cortical (CSTC) model addresses well-established circuits between the cortex and the thalamus that are necessary for control of sensory information flow to the cortex and by extension the regulation of awareness and attention. This model emphasizes the impacts of psychedelics and specifically 5-HT 2A receptor activation on cortico-thalamic circuits to explain the subjective effects of psychedelics. Specifically, the model proposes that psychedelics impede sensory gating functions of the thalamus, allowing increased sensory and interoceptive information flow from thalamus to cortical regions. This reduction in sensory gating is proposed to lead to a literal kind of sensory overload of the cortex that results in both perceptual effects and cognitive changes that are observed during the acute effects of psychedelics. Proponents of this model also refer to theories of consciousness that prioritize these same cortico-thalamic circuits, suggesting that activity in these loops contributes to conscious experience. Preller and colleagues have suggested that “[the thalamus] also plays a key role in various neurobiological theories of consciousness, suggesting that neural activity in thalamo-cortical loops give rise to conscious experience", citing Ward’s and Tononi and Edelman’s theories of consciousness that have forefronted these same cortico-thalamic circuits when discussing potential neurobiological bases of consciousness. Thus, parts of this model of psychedelic effects have also been proposed as a potential explanation of phenomenal consciousness and the hard problem of consciousness.

Supporting the CSTC model, LSD increases global thalamic connectivity, thalamus-to-cortex connectivity, and effective thalamic connectivity to both the cortex and the striatum while reducing effective cortico-to-thalamic connectivity. Increased thalamic connectivity has been associated with the perceptual and other subjective effects of LSD. Animal models of the effects of psychedelics on pre-attentive sensory gating have provided supporting evidence for the CSTC model. However, findings of the effects of psychedelic drug administration on thalamic metabolic activity are mixed. In general, the CSTC model appears be a productive theory for generating hypotheses that better specify the circuitry supporting perception, attention, and executive function through the study of psychedelic drug action on these systems. The CSTC model may thus help to explain how the contents of sensory and interoceptive stimuli come into awareness; however, there appears to be little reason to hope for an answer to the hard problem of consciousness.

Another model of psychedelic effects, the claustro-cortical circuit model, emphasizes the role of the claustrum in mediating psychedelic drug effects. The claustrum is a thin brain structure positioned lateral to the putamen and between the external and extreme capsules, and which is heavily interconnected to a large number of cortical regions. In Francis Crick’s final paper, he and Cristof Koch proposed that the claustrum, due to its widespread cortical connectivity, may provide a multisensory binding function and thus may be a key brain structure for understanding how phenomenal conscious experience may arise from brain function. Here is yet another high-profile claim that a particular brain function (that has also been featured in models of the effects of psychedelics) could explain phenomenal consciousness. Crick and Koch used the metaphor of the claustrum as a “conductor” and the cortex as an “orchestra” to illustrate how the claustrum might coordinate the activity of functionally and spatially disparate brain regions give rise to phenomenal consciousness. More recent work does not support this binding function for the human claustrum. The potential role of the claustrum in mediating altered states of consciousness was more recently proposed, given the high density of neural receptor targets of classic (i.e., the serotonin 2A receptor) and atypical (e.g., the kappa-opioid receptor, target of salvinorin A) hallucinogens. It has further been proposed that amplification of neuronal avalanches (bursting among neuronal populations that can achieve a supercritical spread of activity) via 5-HT2A activation in the claustrum may be a mechanism of psychedelic action. A possible claustrum-cortical model of psychedelic drug action was subsequently supported from empirical observations showing that psilocybin alters connectivity between the claustrum and both the default mode and fronto-parietal attention networks in the human brain. Such networks were also identified as central to claustrum involvement in supporting cognitive control under non-drug conditions. This observation is supported in animal findings, which indicate a role for the claustrum in mediating cognitive processes under high cognitive demand or sensory conflict. Initial evidence suggests that psychedelics alter the instantiation of cortical cognitive networks through changes in claustrum activity. Just as in the 2 previous neural models, and contrary to Crick and Koch’s conjectures, there is no current evidence suggesting a testable hypothesis of the hard problem of consciousness.

Each of these models (REBUS, CSTC, and the claustro-cortical circuit model) may generate testable hypotheses regarding key aspects of subjective experience, including affect, and elements of cognition. There are also other models of psychedelics that relate to claims about consciousness about which similar conclusions can be drawn. In each case, psychedelics play an important role in testing the parameters of these models and, in some cases, may provide important insights to various “easy problems” of consciousness through their use as a research tool. However, no apparent explanation lies in any of these models for the hard problem of consciousness.

The Subjective Effects of Psychedelics and the easy Problems of Consciousness

In addition to neuroscientific models of consciousness listed above, there are operationalizations of consciousness that fall within the easy problems of consciousness that focus on carefully characterizing particular aspects of conscious awareness. For example, within phenomenal consciousness, there is a long-standing scientific question on whether consciousness should be considered continuous or discrete. While phenomenal consciousness appears continuous (imagine watching someone walk across your field of vision or hearing a melody), it appears so despite the fact that we only have access to individual moments of time at any given instant. Scientific theories of this kind of conscious awareness generally involve formal models that propose varying degrees and stages of nonconscious processing preceding conscious awareness. These theories involving conscious perception are tested in experimental paradigms such as the attentional blink task, which demonstrates that varying the duration of extremely rapid presentation of stimuli can reveal differentiable non-conscious and conscious perception processes. Another common task in this context is binocular rivalry, which involves presenting 2 images that compete for perceptual dominance and then determining behavioral or neural correlates associated with perceiving one or the other image. When psilocybin was administered during the binocular rivalry task, it reduced the rate of binocular rivalry switching. It will continue to be valuable to test the impact of psychedelics on these and related tasks and in the context of these and other models. Nevertheless, there is little reason to think that states evoked by psychedelic drugs will have a different kind of effect on these models and their related tasks compared with states evoked by any other psychoactive substance. Effects of different psychoactive drugs on these tasks instead will likely differ in terms of degree.

One meaning of the term “consciousness” where psychedelics clearly do have potential to aid scientific investigation is their capacity to produce substantially altered states of consciousness of a particular kind. Altered states of consciousness are defined in the subjective terms of a deviation of aspects of one’s awareness, such as perceived deviations in perception, affect, and cognition from “normal,” or one’s most common waking state of awareness. There is a continuum of alterations from one’s normal state of consciousness, with relatively minor effects induced by caffeine, for instance, to the more intense alterations to perception, affect, and cognition resulting from psychedelic substances (i.e., the effects of LSD differ from those of a cup of tea). Beyond the mere magnitude of the difference from “normal” or “ordinary” states of consciousness, there are questions embedded in this meaning of consciousness regarding the dimensionality of altered states of consciousness (discussed below).

The particular altered states of consciousness elicited by psychedelics have been characterized in several different ways. Psychedelics have purportedly been used for thousands of years in ritual contexts across a number of different cultures, presumably due to their capacity to alter the contents of consciousness in a way deemed meaningful and usually connected to religio-spiritual beliefs. When scientific research began on psychedelics in the mid-20th century, they were initially studied for their potential “psychotomimetic” properties (i.e., mimicking a state of psychosis similar to acute phases of schizophrenia. This pathologizing characterization was disputed after further research demonstrated that psychedelics (taken under supportive conditions) can produce positive experiences with beneficial consequences and limited impairment of reality testing, as opposed to the suffering and negative consequences typically experienced by individuals with psychotic disorders.

The specific altered states of consciousness induced by psychedelics are generally characterized as potentially including a heightened sense of connection, complex imagery, synesthesia, and/or other changes to perception and cognition, as often measured with self-report using the 5-dimensional altered states of consciousness scale. Additionally, psychedelics appear to influence one’s subjective sense of self––or the lack thereof––which is commonly referred to as ego dissolution or self-transcendent experience. These are changes to one’s awareness of their sense of self or to self-consciousness.

Drawing on scholarship from William James and others, particular altered states of consciousness that can be elicited by psychedelics have also been characterized as “mystical-type” experiences, routinely measured with instruments such as the Mystical Experience Questionnaire 30, which has 4 factors that evaluate (1) feelings of unity and changes to the sense of self, profundity, and that the experience seems extraordinarily real (sometimes referred to as the noetic quality); (2) positive emotions; (3) alterations to the senses of time and space; and (4) ineffability (that the experience is difficult to adequately describe using words). There are undoubtedly a number of more specific cognitive and affective processes at play within these broad factors. Importantly, psychedelics have proven a reliable means to elicit such mystical-type effects, and these experiences have been associated with a number of persisting benefits in both healthy and clinical samples. If one is particularly interested in altered states of consciousness of the kind described here (including similar altered states arising from other triggers), then psychedelics are likely the most important research tools currently available given the relative reliability and magnitude in which they can occasion such effects. As such, psychedelics appear to be powerful tools for investigating some kinds of substantially altered states of consciousness in controlled laboratory settings, and understanding the ramifications of such altered states may be important for understanding the effects of these drugs on mental health.

The kind of altered states of consciousness that psychedelics elicit are presumably influenced by the specific psychedelic substance as well as the apparent dose, expectations, context, bioavailability of the given drug formulation, and many other biopsychosocical factors specific to the psychedelic experience. The nomological network of altered states of consciousness elicited by psychedelics is currently poorly specified, likely due to the unusual nature of these effects and the relative lack of systematic research of such effects in controlled laboratory settings. Psychedelic research provides the possibility of standardizing many features of the dose and the surrounding circumstances under which such altered states of consciousness occur. Notably, the measure of other kinds of mental states, like emotions, was just a few decades ago perceived as too vague and inherently subjective for scientific study; however, there are now robust findings regarding the characterization of emotions (e.g., dimensions of valence and arousal) and their various physiological and behavioral effects. It is possible that psychedelics will allow altered states of consciousness to follow a similar path of scientific inquiry as emotions by providing a reliable means to induce and influence them in controlled settings.

Beyond the measurable changes described above, other changes occur during psychedelic experiences that could be described as even more abstract psychological processes. Many of these processes could broadly be construed as involving changes to one’s self-consciousness, or awareness of aspects of one’s self (e.g., bodily self, perspectival self, volitional self, narrative self, social self). Individuals undergoing psychedelic experiences often have experiences and insights pertaining to certain features of their own sense of self-awareness. These experiences may include mental processes related to the sense of self, autobiographical reflection, or perceiving meaningful eidetic imagery. Other insights may include existential concepts such as the potential embodied nature of the mind or how some suffering is optional. Such insights may come about due to the aforementioned subjective experiences that can be occasioned by psychedelics. The creativity literature, for example, discusses similar insights in the concept of “diversifying experiences”, which may involve cognitive restructuring of fundamental beliefs after encountering an experience that is far from your “normal” or modal set of everyday experiences. While psychedelics may provide some individuals with some insights into profound-seeming features of their own consciousness, this does not mean that these insights from psychedelic experiences necessarily play a role in identifying scientific ground truth beyond that of introspective insights in general. To be clear, the “insights” that people have under the influence of psychedelics may be false, although the relative frequencies of true and false insights that people tend to have under these conditions remains an open question.

Finally, psychedelics, and the type of altered states they produce, may alter one’s beliefs about the nature of consciousness. Some have proposed that psychedelic experiences may prompt people to move away from materialist views regarding the nature of consciousness, and correlational data suggest this can occur to some degree in some samples; however, crucially, the magnitude of these changes and the population rates at which these occur are not known. This may be due, at least in part, to the noetic sense associated with psychedelic states, which leads people to feel as though what is intuited or perceived in this state has the quality of feeling real––often somehow “more real” than one’s ordinary state of mind. Such subjective changes may contribute to statements concerning “levels of consciousness,” or abstract sensations of intensity involved with one’s attention and awareness. Feelings of unity and ego dissolution elicited by psychedelics may contribute to alterations in attribution of selfhood and agency. Changes to cognitive modules related to mind perception, which involves the attribution of the capacity for experience and agency to entities/objects, during some altered states of consciousness may also impact one’s beliefs related to what else (other than human beings) has phenomenal consciousness. However, a survey of professors of philosophy found no association between psychedelic use and non-materialist views of consciousness, providing evidence that this relationship varies across samples. While further research is required to clarify such effects, it is certainly possible to measure people’s beliefs about the nature of and explanations of consciousness as well as how psychedelic experiences tend to impact those beliefs.

Conclusion

The scientific study of psychedelics and consciousness, in all of its meanings, is still nascent. While we cannot, at present, see any clear scientific traction resulting from the intersection of psychedelics and the hard problem of consciousness, we are open to the possibility of being proven wrong. We find the relationship between psychedelics and consciousness (in every sense) fascinating, but we also believe that it is important to be clear about which sense of the term consciousness is being used at any given time and to ensure claims regarding explanations of phenomenal consciousness are differentiated from claims about the contents of consciousness (which includes the set of changes to perception, affect, and cognition in what are called altered states of consciousness). We believe this is essential for clear communication among scientists as well as in public science communication. While psychedelics surely impact many phenomena associated with the easy problems of consciousness (though they may not do so uniquely), we believe epistemic humility is called for regarding the potential for psychedelics to illuminate the hard problem of consciousness. Due to the epistemological questions surrounding consciousness, it currently appears unlikely that psychedelics, like other extant scientific tools, could be used to definitively explain the existence of or biological basis of phenomenal consciousness (i.e., solve the “hard problem”); however, psychedelics are proving useful tools for researchers investigating many of the so-called easy problems of consciousness, and it seems likely that their full potential to facilitate scientific advances is only beginning to be tapped.

*From the article (including references) here.​
 
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Dimensions of Consciousness and the Psychedelic State

Tim Bayne and Olivia Carter [2018]

It has often been suggested in the popular and academic literature that the psychedelic state qualifies as a higher state of consciousness relative to the state of normal waking awareness. This article subjects this proposal to critical scrutiny, focusing on the question of what it would mean for a state of consciousness to be ‘higher’. We begin by considering the contrast between conscious contents and conscious global states. We then review the changes in conscious global state associated with psychedelic drug use, focusing on the effects of two serotonergic hallucinogens: psilocybin and LSD. Limiting our review to findings obtained from lab-based experiments and reported in peer-reviewed journals, we prioritize the more common and reliably induced effects obtained through subjective questionnaires and psychophysical measures. The findings are grouped into three broad categories (sensory perception, cognitive function, and experiences of unity) and demonstrate that although certain aspects of consciousness are improved or enhanced in the psychedelic state, many of the functional capacities that are associated with consciousness are seriously compromised. Psychedelic-induced states of consciousness are indeed remarkable in many ways, but it is inappropriate to regard them as ‘higher’ states of consciousness. The fact that psychedelics affect different aspects of consciousness in fundamentally different ways provides evidence against the unidimensional (or ‘level-based’) view of consciousness, and instead provides strong support for a multidimensional conception of conscious states. The final section of the article considers the implications of this analysis for two prominent theories of consciousness: the Global Workspace Theory and Integrated Information Theory.

It has often been suggested in the popular and academic literature that the psychedelic state qualifies as a higher state of consciousness relative to the state of normal waking awareness. This article subjects this proposal to critical scrutiny, focusing on the question of what it would mean for a state of consciousness to be ‘higher’. We begin by considering the contrast between conscious contents and conscious global states. We then review the changes in conscious global state associated with psychedelic drug use, focusing on the effects of two serotonergic hallucinogens: psilocybin and LSD. Limiting our review to findings obtained from lab-based experiments and reported in peer-reviewed journals, we prioritize the more common and reliably induced effects obtained through subjective questionnaires and psychophysical measures. The findings are grouped into three broad categories (sensory perception, cognitive function, and experiences of unity) and demonstrate that although certain aspects of consciousness are improved or enhanced in the psychedelic state, many of the functional capacities that are associated with consciousness are seriously compromised. Psychedelic-induced states of consciousness are indeed remarkable in many ways, but it is inappropriate to regard them as ‘higher’ states of consciousness. The fact that psychedelics affect different aspects of consciousness in fundamentally different ways provides evidence against the unidimensional (or ‘level-based’) view of consciousness, and instead provides strong support for a multidimensional conception of conscious states. The final section of the article considers the implications of this analysis for two prominent theories of consciousness: the Global Workspace Theory and Integrated Information Theory.

Charting the Psychedelic State of Consciousness

We turn now to the nature of the psychedelic state of consciousness, focusing on two of the most commonly used serotonergic hallucinogens: lysergic acid diethylamide (LSD) and psilocybin (found in ‘magic mushrooms’). Although there are differences between the states of consciousness associated with the ingestion of these two substances, and there are a range of other drugs known to induce altered states of consciousness, we will ignore these points here and will use ‘psychedelic state’ as a general term to refer to the paradigmatic states of consciousness associated with the consumption of psilocybin and LSD.

In this theoretical analysis, we will concentrate on reported subjective changes to an individual’s conscious experience (as measured by questionnaires), and psychophysical measures of basic perceptual and cognitive functioning. We will not consider the neural or physiological changes associated with psychedelics. This decision should not be seen as questioning the value of that work. Rather our focus on the subjective reports and behavioural measures follows a long tradition of consciousness research that is motivated by the quest to understand ‘what it is like’ to be in a specific state of consciousness. Although we have sampled across a broad range of relevant psychophysical and behavioural studies, for the subjective reports we have limited ourselves to studies using the English or German (OAV) versions of the Altered States of Consciousness (ASC) rating scales adapted from Dittrich’s APZ (Abnormal Mental States) questionnaire. We have limited our analysis to studies that employ this scale as it is well validated and has been used by multiple research groups to capture the effects of both psilocybin and LSD. Importantly, this questionnaire has also been the focus of a rigorous clustering analysis of 327 individual psilocybin sessions drawing from multiple psilocybin studies conducted over many years.

There are a number of ways in which one might structure a discussion of changes in consciousness that are associated with the psychedelic state. Here, we focus on three broad aspects of consciousness for which psychedelic-induced changes are reported in the literature: (i) sensory and perceptual experience; (ii) cognitive capacities; and (iii) experiences relating to time, self and space. Let us consider these in turn and ask when it might be appropriate (or inappropriate) to label these different aspects of consciousness ‘higher’ or ‘lower’ relative to normal waking awareness.

Psychedelics and perception

The reputation of psychedelics as ‘mind-expanding’ suggests that they bring with them an expansion in the range of contents that enter consciousness. Here, we consider whether this claim is supported by the self-report and objective psychophysical findings relating to various aspects of perception.

Visual imagery and perceptual meaning

We begin by considering the impact of psychedelics on imagery. In the cluster analysis of the 327 psilocybin sessions performed by Studerus et al, the two factors from the ASC questionnaire that receive the highest scores both related to visual imagery. The first was ‘Elementary Imagery’ (including items such as ‘I saw colours before me in total darkness or with closed eyes’) and the second was ‘Complex Imagery’ (with items like ‘I could see pictures from my past or fantasy extremely clearly’). Scores for these same factors were also increased after LSD consumption. In respect to qualitative self-report data, one study found that autobiographical memories were judged to be both ‘more visual’ and ‘more vivid’ after taking psilocybin. LSD was also found to enhance dream-like imagery in a lab-based setting, and self-reports of hallucinogen experiences showed high semantic similarity with dream reports across large community-based self-report repositories.

The factor ‘Changed Meaning of Percepts’ captures reports of objects in an individual’s environment as appearing more salient and personally significant than they ordinarily do. Here, participants who have taken psychedelics are more likely to endorse items such as ‘Objects around me engaged me emotionally much more than usual.’ Psilocybin and LSD have also been found to enhance the subjective experience of colour. For example, after-images are described as containing more colours, and the flicker-based generation of colour experience is said to be enhanced. These reports mirror those that are commonly found in popular writing, such as those found in Aldous Huxley's book ‘Heaven and Hell: First and most important is the experience of light. Everything seen by those who visit the mind’s antipodes is brilliantly illuminated and seems to shine from within. All colours are intensified to a pitch far beyond anything seen in the normal state, and at the same time the mind’s capacity for recognizing fine distinctions of tone and hue is notably heightened.’

However, it is unclear to what extent these reports reflect objective improvements in colour perception, for laboratory-based studies have failed to find any evidence of visual improvements as the result of ingesting psychedelics. In one study, both psilocybin and LSD were found to impair objective measures of hue discrimination despite the participants’ subjective reports of enhanced colour perception. Another study found no evidence that psilocybin was associated with increased sensitivity to stimulus contrast or brightness. It is an open question how the subjective increase in the richness and vividness of colour experience might be reconciled with the fact that psychedelics are not associated with any objective improvements in colour or brightness perception.

The bandwidth of consciousness

There is also evidence that the psychedelic state might be associated with an increase in the amount of sensory content that can enter consciousness at any given time. One of the most frequently studied paradigms used to measure psychedelic effects on sensory processing involves pre-pulse inhibition (PPI). PPI is defined in terms of a reduction in the natural startle reflex (measured as the magnitude of an eye-blink response in humans) that typically occurs if a startle tone stimulus is preceded by another tone (the pre-pulse). The relative reduction in this inhibitory response is widely regarded as a behavioural measure of ‘sensory gating.’ PPI has been used extensively to assess the impact of psychedelic drugs as well as altered sensory processing associated with psychiatric conditions such as schizophrenia. Psilocybin has been found to cause reduced PPI, which is taken as evidence of lower levels of sensory gating and an increase in the amount of sensory information that is ‘making it through’ to conscious awareness.

Another line of research supporting the idea of reduced perceptual suppression (or an ‘increased permeability’ of consciousness) comes from a series of studies involving binocular rivalry with observers reporting a greater proportion of time experiencing mixed or incomplete perceptual suppression. Using a very different measure of sensory sampling (saccadic eye movements), psilocybin and LSD were also both found to increase the frequency of saccadic eye-movements. While this study did not measure changes in sensory performance, it is clearly possible that such increases in saccade frequency could allow for a higher ‘sampling rate’ as a person views their environment. In respect to the ASC questionnaire, one of the few items relevant to this point—‘Everything around me was happening so fast that I no longer could follow what was going on’—was more likely to be endorsed after psilocybin. Although these studies do not allow us to quantify the amount of sensory information that makes it into consciousness, they do provide consistent and compelling support for the claim that psychedelic drugs may increase the ‘bandwidth’ of perceptual experience.

In summary, with respect to the subjective experience of the psychedelic state, there is compelling evidence for an increase in the intensity and volume of sensory information experienced at any given time. When we consider objective measures of perceptual function, there is also good support for reduced perceptual suppression leading to a real increase in the permeability or bandwidth of consciousness. However, there is less objective support for improvements in either brightness or colour sensitivity, despite repeated self-reports suggesting that psychedelics enhance brightness and colour perception.

Psychedelics and cognition

We turn now to issues of cognitive and behavioural control. In the state of ordinary alert wakefulness, conscious contents are able to guide and control a wide-range of cognitive and behavioural operations, such as those that are implicated in working memory, attention, communication, decision-making, creativity and abstract thought. As we have noted, these capacities are invariably compromised in states of consciousness associated with brain trauma or epileptic seizures, thus undermining the ability of individuals to pursue their goals in an intelligent and flexible manner. What impact do psychedelics have on these capacities?

In general, the psychedelic state appears to be strongly associated with impairments in cognitive and behavioural control. Indeed, one of the largest clusters identified in the analysis by Studerus et al. is labelled ‘Impaired Control and Cognition’, and includes statements such as ‘I had difficulty making even the smallest decision’. However, as outlined below there are also suggestions that psychedelics can increase creativity and other aspects of cognitive function.

Memory, attention and communication

In regard to memory, one study found that after consumption of LSD participants were unimpaired on tests of declarative memory (e.g. ‘How old are you?’ ‘Who is the president?’ ‘Where are you?’) and learned associations (e.g. metal, iron, hard etc.). However, the same participants did show impairments in tasks involving mental control and the manipulation of new items (e.g. counting backwards, serial addition, reproducing brief passages of text and visual reproduction through drawing). Interestingly, measures of working memory—such as repeating a series of digits forwards or backwards—were unimpaired. This sparing of working memory function is consistent with studies involving psilocybin showing slower reaction times but no reduction in accuracy during spatial working memory tasks involving the recall of spatial locations.

In contrast with the variable effects of psychedelics on memory, the impact of psychedelics on attention seems to be more consistent. Using psychophysical measures, psilocybin has been found to impair measures of sustained, divided and covert orienting of attention also describe difficulties in concentration as one of the disturbances that is most frequently seen in LSD.

Relatively little is known about the impact of psychedelics on communication, although early reports indicate clear communication impairments during the psychedelic state. For example, a study of the effects of LSD by Deshon et al. highlighted marked impairments in speech production seen across all subjects. One participant experienced complete blocking of speech for around 3 h. The subject was able to read when requested to do so but was unable to generate spontaneous utterances or answer questions except by gestures. This participant subsequently reported an inability to put into words the thoughts he wished to express. It is unclear to what extent these difficulties in comprehension are related to the deficits in memory, attention, and mental control that we have reviewed.

Creativity, insight, and abstract thinking

One cognitive domain in which psychedelics have been said to augment functionality involves creativity. Certainly, individuals in the psychedelic state often claim to have had novel insights into conceptual problems. One of the 11 clusters identified by Studerus et al. has been termed ‘Insightfulness’ and includes statements such as ‘I had very original thoughts’ and ‘I gained clarity into connections that puzzled me before.’ Carhart-Harris et al. have referred to this dimension of the psychedelic state in terms of an ‘unconstrained style of thinking’. The idea that psychedelics might foster creativity is supported by an earlier line of research that examined the effects of psilocybin on semantic associations using word-priming. Comparing direct (e.g. ‘black-white’) and indirect (e.g. ‘lemon-sweet’) word pairs, psilocybin was found to significantly increase indirect but not direct semantic priming. This was interpreted as evidence that psilocybin increased the availability of remote associations, which in turn made a wider array of thoughts available to the agent. However, it should also be noted that the authors of this study suggest that the indirect priming effect might be associated with cognitive impairments, insofar as it reflects a decreased capacity to use contextual information for semantic processing.

These findings suggest that psychedelics enhance the capacity to formulate novel thoughts, but this capacity is only one aspect of creativity. A second—and no less important—aspect of creativity is the capacity to distinguish novels thoughts that are genuinely insightful from those that merely seem to have those properties. We know of no evidence that psychedelics enhance this capacity, and the self-report data suggest that they actually impair it. Consider the following three items from the ASC, each of which received high ratings: ‘Everything around me was happening so fast that I no longer could follow what was going on; I had difficulty in distinguishing important from unimportant things’; and ‘Conflicts and contradictions seemed to dissolve’ received high ratings. An impairment in the capacity to detect contradictions could hardly foster abstract thought given the importance that this capacity plays in the evaluation of evidence and argument. Further evidence in favour of the idea that psychedelics impair the evaluative dimension of thought is provided by Deshon et al. (1952), who describe LSD as giving rise to a ‘flight of ideas with rhyming and punning, preoccupation, irrelevant, and pedantic imitation’. (p. 37), and as leading to an ‘overgeneralized and tangential’ style of thought (p. 47). They also found that LSD impaired the ability of subjects to understand proverbs, a finding that was subsequently replicated by Silverstein and Klee. Findings that psychedelics impair the evaluative dimensions of abstract thought are in line with the parallels that previous researchers have drawn between certain aspects of the psychedelic state and the psychotic state. Indeed, psychedelics are sometimes referred to as ‘psychotomimetics’ (psychosis-mimicking drugs), a term that reflects the view that the psychedelic state can be usefully viewed as a partial model of psychosis.

In summary, psychedelics seem to impair many of the central elements of cognition: decision-making, memory, attention and abstract thought. Although psychedelics appear to enhance the capacity to generate novel ideas, they also seem to impair the capacity to evaluate these ideas and distinguish those that represent genuine cognitive advances from those that do not. Based on the evidence available, it seems plausible that the increase in salience and/or amount sensory information experience (real or imagery-based) may itself be sub-optimal for higher-level functions. Finally, the deep commonalities between the ‘unconstrained’ style of thought seen in psychedelics on the one hand and that seen in psychosis, delusions and dream states on the other is itself an indication that psychedelics do not lead to a ‘cognitively optimal’ state.

Psychedelics and the experience of unity (time, space and self)

The cluster analysis performed by Studerus et al. identified a single factor—labelled ‘Experience of Unity’—that accounted for a shared increased experience of unity (dissolving of boundaries) relevant to both time and self. In light of the fact that behavioural investigations have explored the sense of unity for time and self independently, we too will begin by considering these two dimensions of unity independently before considering the eroding of boundaries more generally.

Time

One key feature of the psychedelic state is a distorted experience of time, with subjects typically reporting that time has stopped or slowed. In respect to items in the ASC questionnaire, participants reported high levels of agreement with statements such as ‘I experienced a touch of eternity’ and ‘I experienced past, present and future as an oneness.’ Using objective measures of time perception based on interval matching or reproduction, a number of studies have shown significant impairments in both humans and mice in the psychedelic state. For example, psilocybin was found to significantly shorten subjects’ reproduction of temporal intervals longer than 2.5 s and impair their ability to synchronize to inter-beat intervals longer than 2 s.

Self and space

Another consistent finding is that psychedelics alter the experience of the self. More specifically, subjects often experience a breakdown in the perceived boundary between themselves and their environment, a phenomenon that is often termed ‘ego-dissolution.’ In the analysis by Studerus et al., ‘the experience of unity’ cluster clearly identified aspects of dissolving self-boundaries, with statements such as ‘The boundaries between myself and my surroundings seemed to blur’ and ‘It seemed to me that my environment and I were one’. Although objective measures of self-perception are yet to be used in lab-based experiments, two recent studies have replicated earlier reports of the experience of ego-dissolution after administration of psilocybin and LSD.

Interestingly, data from the ASC questionnaire appears to identify a distinction between the perception of the self/other boundary dissolving when compared with the sensation of ‘disembodiment’, which is linked to statements such as ‘It seemed as though I did not have a body anymore’ and ‘I had a feeling of being outside my body’. In contrast to the relatively strong impact of psychedelics on the experience of unity and dissolution of self-boundaries, Studerus et al. found that psilocybin was not as clearly associated with a sense of disembodiment typical of dissociative anaesthetics such as ketamine. This distinction might reflect the fact that the experience of disembodiment requires a robust sense of the boundary between oneself and one’s environment.

General boundaries

The fact that the items relating to self and time cluster together suggests that the underlying feature being captured here is a generalized weakening or dissolution of the natural boundaries and segmentation that structure perceptual experience. Indeed, certain items in the ASC questionnaire reflect a very generalized experience of unification, such as ‘Everything seemed to unify into a oneness’. At a much more basic perceptual level, Carter et al. found that psilocybin impaired the integration and grouping of low-level sensory signals required for the detection of coherent motion patterns. Using Kanizsa figures, psilocybin was also found to reduce/impair amodal completion, a process that is important for identifying the boundaries of objects and segmenting scenes within the visual environment. The prevalence of synaesthesia in the psychedelic state could also be regarded as an example of inappropriate binding. One cluster identified within the ASC questionnaire included such items as ‘The shape of things seemed to change by sounds and noises’ and ‘Noises seemed to influence what I saw.’.

Whether these alterations in the experience of unity involve improvements or impairments in conscious processing partially turns on contested issues concerning the nature of reality. Consider, for example, the question of how the phenomenon of ego-dissolution should be understood. Those who ascribe to a ‘no-self’ view of ultimate reality might argue that the experience of ego-dissolution isn’t an illusory experience, but instead involves a new and important insight into reality. However, even if the self is ultimately a fiction, a well-functioning organism must be able to distinguish changes in its environment that are due to its own activity from changes that are due to the activity of other agents. Thus, it seems likely that a blurring of the boundaries between future and past or oneself and others will compromise cognitive and behavioural function.​

Implication for Consciousness Science

We turn now from surveying the general impact of psychedelics on consciousness to the question of what lessons these data have for accounts of consciousness. In our view, the lessons to be drawn are both negative and positive.

Negatively, it is clear that the analysis of the psychedelic state puts further pressure on the idea that conscious states can be understood in terms of levels of consciousness. As we noted earlier, a central implication of the levels-based account is that distinct conscious states (S1 and S2), can be given a total ordering, such that either S1 is higher than S1 or vice-versa. However, it is clear from the previous sections that the psychedelic state is neither higher nor lower than the state of ordinary waking awareness. Although there are certain respects in which the psychedelic state is arguably ‘higher’ than the state of ordinary waking awareness (e.g. it is associated with increases in the richness and vividness of mental imagery), there are other respects in which the psychedelic state is arguably ‘lower’ than the state of ordinary waking awareness (e.g. it is associated with impairments in cognitive capacities such as attention, memory, communication and abstract reasoning). In short, although the conscious state associated with psychedelics is clearly distinct from the conscious state that characterizes ordinary waking awareness, there is no determinate sense in which one of these two states is ‘higher’ or ‘lower’ than the other (Fig. 1).

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Figure 1.
A schematic summary of the key aspects of consciousness discussed in this paper, which illustrates the inappropriateness of a unidimensional account of consciousness.

This is important for a number of reasons. Firstly, it raises questions about the recent suggestion that psychedelics might be useful in treating patients with disorders of consciousness (DoC) such as the vegetative state and the minimally conscious state. This proposal looks attractive if one assumes that the psychedelic state is ‘higher’ than the state of ordinary waking awareness in precisely the same sense that disorders of consciousness are ‘lower’ than the state of ordinary waking awareness. However, the considerations provided in this article undermine that assumption. This point, together with the fact that psychedelics impair certain aspects of cognition and have the potential to disrupt the perception of space, time and the self, raises serious questions about their therapeutic value in the context of treating DoC patients.

Second, the rejection of the levels-based account suggests that some of the most influential theories of consciousness need to be significantly revised. Consider, for example, the Global Workspace Theory (GWT) of consciousness. Although advocates of the GWT have said little about precisely how their account captures changes in conscious state, presentations of the theory typically assume a rather simplistic conception of conscious states. For example, Dehaene et al suggest that changes in conscious state involve nothing more than ‘vigilance’ and ‘wakefulness’, and that although elucidating the brain mechanisms of vigilance and wakefulness ‘is an essential scientific goal’, ‘its computational impact [on theories of consciousness] seems minimal.’ These statements are puzzling, for it is clear that the changes in a creature’s conscious state have a fundamental impact on the functional role of consciousness. (Consider, for example, the way in which psychedelics alter attention, decision-making and working memory.) Dehaene et al. overlook this fact because they regard the global availability of content as an ‘essential’ feature of consciousness—that is, a property that is present when, and only when, an organism is conscious. But the multidimensional account of conscious states suggests that ‘global availability’ is not an all-or-none phenomenon, for there are conscious states in which the conscious contents are available for only some forms of high-level control. In order to be a viable theory of consciousness, GWT will need to be developed so as to accommodate the multidimensional nature of consciousness.

The data that we have reviewed also pose a challenge to the Integrated Information Theory (IIT) of consciousness, an influential complexity-based theory of consciousness. Advocates of IIT are explicitly committed to the unidimensional view of conscious states, for they equate a creature’s conscious state with its level of consciousness, and degrees of consciousness, according to IIT, are in turn understood in terms of the amount of integrated information (Φ) associated with the relevant system. The considerations advanced in this paper raise questions about the plausibility of this view, for we have seen that global states cannot be ordered along a single dimension. Of course, there are algorithms that can transform highly non-linear dynamic states into values that can be ordered along a single dimension. However, this is conceptually problematic, for it is far from clear that it is coherent to describe one individual as more or less conscious than another. The psychedelic state involves a conscious state that certainly differs from the conscious state associated with ordinary waking awareness, but there is no reason to think that individuals in the psychedelic state are more conscious (or, for that matter, less conscious) than individuals who are not in it. If it is to be a viable theory of consciousness, IIT too will need to be developed so as to accommodate the multidimensional nature of consciousness.

Positively, the analysis of the psychedelic state provides an important source of data for attempts to develop a multidimensional account of conscious states. By identifying the patterns of association and dissociation that characterize the psychedelic state we can determine the state space in terms of which conscious states are structured. Why do psychedelics increase the vividness, complexity and possibly also the bandwidth of sensory experience? Why do they impair an individual’s capacities for various forms of high-level cognitive and behavioural control? What explains the systematic effects that psychedelics have on the experience of unity across a wide range of domains (e.g. time, space and the self)? Addressing these questions will help us to identify the various dimensions that structure consciousness. This task should be pursued in tandem with the investigation of other conscious states, such as those that are associated with sleep, sedation, and the post-comatose disorders of consciousness. For example, we might ask whether attention qualifies as a separate dimension within this state-space, or whether changes in conscious state are better modelled by distinguishing between different aspects of attention (for example, sustained attention versus selective attention).

The study of psychedelics also provides an important—and neglected—source of data for understanding the neural basis of consciousness. We know a lot about the neurobiology of psychedelics (for a detailed review see. For example, we know that psychedelics act predominantly through 5-HT2A receptor activation, and we know where these receptors are typically located in the brain. Further, through the use of animal models and human neuroimaging studies, we are increasingly able to manipulate these receptors to understand the biological impact of their activation. These techniques provide us with a powerful and under-utilized avenue for understanding the neural basis of consciousness.

Although we have identified some of the more prominent changes in consciousness associated with psychedelic states, we acknowledge the limitations associated with the data we have used. The ASC represents one of the best available self-report measures of psychedelic effects and has impressive reliability and drug selectivity, but it should not be regarded as a comprehensive survey of the impact of psychedelics on consciousness. Thus, although the data surveyed here are incompatible with a unidimensional account of consciousness, they are too limited to allow for a formal assessment of the number of dimensions that would best characterise consciousness. As we gain a better understanding of the ways in which the subjective and functional dimensions of consciousness can change, so too we will gain a better understanding of the dimensional nature of consciousness, and thus better grasp what it would be like to be in each of the various states of consciousness.

*From the article (including references) here :
 
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Johns Hopkins Medicine

New study explores relationship between psychedelics and consciousness

Johns Hopkins Medicine | 31 Mar 2022

Psychedelic drugs, like psilocybin, an ingredient found in so-called magic mushrooms, have shown promise in treating a range of addictions and mental health disorders. Yet, there's something mysterious and almost mystical about their effects, and they are commonly believed to provide unique insights into the nature of consciousness.

Now, a new study by Johns Hopkins Medicine researchers addresses the question of whether psychedelics might change the attribution of consciousness to a range of living and nonliving things.

The findings, published March 28 in Frontiers in Psychology, reveal that higher ratings of mystical type experiences, which often include a sense that everything is alive, were associated with greater increases in the attribution of consciousness.

"This study demonstrates that when beliefs change following a psychedelic experience, attributions of consciousness to various entities tend to increase," says Sandeep Nayak, M.D., postdoctoral research fellow at the Johns Hopkins Center for Psychedelic and Consciousness Research and one of the researchers involved in the study. "It's not clear why, whether that might be an innate drug effect, cultural factors or whether psychedelics might somehow expose innate cognitive biases that attribute features of the mind to the world."

For the study, the researchers analyzed data gathered between August 2020 and January 2021 on 1,606 people who have had a belief-changing psychedelic experience. Participants averaged 35 years of age and were predominately white (89 percent), male (67 percent) and from the United States (69 percent).

Study participants completed an internet-based survey that included questions focused on belief changes attributed to a single psychedelic experience with a classic psychedelic substance (e.g., psilocybin mushrooms, LSD, ayahuasca). The survey also included questions about demographics, psychedelic use, personality, and scientific knowledge and attitudes.

The study found that among people who have had a single psychedelic experience that altered their beliefs in some way, there were large increases in attribution of consciousness to a range of animate and inanimate things. For example, from before to after the experience, attribution of consciousness to insects grew from 33% to 57%, to fungi from 21% to 56%, to plants from 26% to 61%, to inanimate natural objects from 8% to 26% and to inanimate manmade objects from 3% to 15%.

"On average, participants indicated the belief-changing experience in question occurred eight years prior to taking the survey, so these belief changes may be long-lasting," says Nayak.

Classic psychedelics -- the pharmacological class of compounds that includes psilocybin and LSD -- produce visual and auditory illusions and profound changes in consciousness, altering a person's awareness of their surroundings and of their thoughts and feelings. These substances produce unusual and compelling changes in conscious experience, which have prompted some to propose that psychedelics may provide unique insights into the nature of consciousness itself.

"The results suggesting that a single psychedelic experience can produce a broad increase in attribution of consciousness to other things, raises intriguing questions about possible innate or experiential mechanisms underlying such belief changes," says Roland Griffiths, Ph.D., the Oliver Lee McCabe III, Ph.D., Professor in the Neuropsychopharmacology of Consciousness at the Johns Hopkins University School of Medicine, and founding director of the Johns Hopkins Center for Psychedelic and Consciousness Research. "The topic of consciousness is a notoriously difficult scientific problem that has led many to conclude it is not solvable."

 
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Just how far can psychedelics push the boundaries of consciousness?*

by David Nield | Science Alert | 3 Apr 2022

Scientists continue to look into how psychedelic drugs and experiences alter our perception of reality, and a new study suggests that seeing consciousness in inanimate objects is one of the long-term effects.

Relying on self-reported responses to an online survey from 1,606 participants who said they had been through at least one belief-changing psychedelic experience, researchers evaluated how much consciousness the participants attributed to living and non-living entities in the world around them.

On average, belief in the consciousness of non-living and inanimate objects went up significantly after the psychedelic experience: Volunteers reported seeing more consciousness in everything from rocks to chairs.

"This study demonstrates that when beliefs change following a psychedelic experience, attributions of consciousness to various entities tend to increase," says psychiatrist Sandeep Nayak from the Johns Hopkins Center for Psychedelic and Consciousness Research in Baltimore.

"It's not clear why, whether that might be an innate drug effect, cultural factors or whether psychedelics might somehow expose innate cognitive biases that attribute features of the mind to the world."

Study participants rated their feelings based on the psychedelic experience that "led to the greatest belief change" in their lives. The experiences were the result of what the researchers called classic psychedelic substances, including psilocybin mushrooms, LSD, and ayahuasca.

For those who had experienced an episode that changed their beliefs, attribution of consciousness for inanimate natural objects rose from 8 percent to 26 percent on average, and for inanimate human-made objects rose from 3 percent to 15 percent.

Individuals also reported increases in seeing consciousness in plants (26 percent to 61 percent), fungi (21 percent to 56 percent), and insects (33 percent to 57 percent). The changes appear to be widespread and can last well after the experience.

Those involved in the research were 35 years of age on average and were predominately white (89 percent of participants), male (67 percent of participants), and from the US (69 percent of participants).

"On average, participants indicated the belief-changing experience in question occurred eight years prior to taking the survey, so these belief changes may be long-lasting," says Nayak.

Psychedelics are well known for leading to hallucinations both visual and auditory, and for shifting the perception of individual consciousness.

One of the ways in which research like this can be helpful is in the development of psychedelics as treatments for disorders like depression and addiction, and mental health issues where the brain needs to be rewired in some way. There are also signs that controlled, managed use of psychedelics could improve our physical health, too.

The study also tackles something that has been debated by scientists and philosophers alike for centuries: the nature of consciousness itself, a notoriously difficult concept to examine and study.

"The results suggesting that a single psychedelic experience can produce a broad increase in attribution of consciousness to other things, raises intriguing questions about possible innate or experiential mechanisms underlying such belief changes," says psychopharmacologist Roland Griffiths, from the Johns Hopkins Center for Psychedelic and Consciousness Research.

"The topic of consciousness is a notoriously difficult scientific problem that has led many to conclude it is not solvable."

The research has been published in Frontiers in Psychology.

*From the article here :
 

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What psychedelic mushrooms are teaching us about human consciousness

Psychedelic drugs like psilocybin are being tested to treat mental illness. They're also expanding our understanding about human consciousness.

by Iris Kulbatski | DISCOVER | 9 Oct 2020

The scientific world is in the midst of a decade-long psychedelic renaissance. This revolution is expanding our understanding of one of the most captivating scientific puzzles: human consciousness. Numerous research fields are revealing new insights into how psychedelics affect the brain and which neural processes underly consciousness.

Multiple studies testing psychedelic drugs for treating mental illness provide compelling evidence of their therapeutic benefit. Treated disorders have included depression, anxiety, post-traumatic stress disorder, anorexia, obsessive compulsive disorder and addiction. Dozens of clinical trials are underway, the majority investigating the therapeutic effect of psilocybin, the active component in so-called magic mushrooms. This natural compound belongs to the class of serotonergic psychedelics — those that activate serotonin (type 2A) receptors.

Researchers are examining the distribution of serotonin 2A receptors to help pinpoint the brain areas affected by psychedelics. The greater the density of these receptors, the greater the likelihood that a particular brain region contributes to the psychedelic experience, according to a study published in Neuropsychopharmacology. Knowing this helps us understand how psychedelics exert their positive therapeutic effect, as well as which brain regions are involved in various states of consciousness.

Ego, oneness and the claustrum

The claustrum is one of multiple brain regions that is rich in serotonin 2A receptors and organizes brain activity. Cognitive neuroscientist Frederick Barrett and colleagues at the Johns Hopkins Center for Psychedelic and Consciousness Research recently examined how psilocybin affects neural activity in the claustrum.

Published in NeuroImage, their breakthrough study used real-time brain scans in humans to show that psilocybin reduces activity in the claustrum by up to 30 percent. This coincides with people's subjective feelings of ego dissolution and oneness with their environment while under the influence of the drug. The less active the claustrum, the stronger the psychedelic effect reported by participants, including mystical and emotional experiences, and a reduced sense of self. The authors write that the work “supports a possible role of the claustrum in the subjective and therapeutic effects of psilocybin.”

In this mysterious part of the brain, a thin sheet of neurons sends and receives signals to and from other brain regions. Growing evidence suggests the claustrum orchestrates consciousness — gathering, sending and integrating information from almost every brain region. Some, like neuroscientist Christof Koch, believe that the sense of self and ego rest here.

Several years ago, Koch and colleagues of the Allen Brain Institute for Brain Science found anatomical evidence in mice to support this idea. They identified several large neurons projecting from the claustrum, with one wrapping around the circumference of the brain. Around the same time, they published a paper in the Journal of Comparative Neurology describing the vast connections between the claustrum and various brain regions in mice.

Barrett says that “while the claustrum has received attention as a potential mediator of consciousness as well as psychedelic experience, our current thinking is that the claustrum helps to integrate and orchestrate the coherence of brain networks as they support perception and cognition.”

States of consciousness

Variations in activity levels of the claustrum are associated with different states of consciousness. For example, the claustrum coordinates synchronized slow-wave activity in the brain. This particular state of consciousness is a feature of certain deep sleep stages during which the brain maintains synapses and consolidates memories. Neuroscientist Yoshihiro Yoshihara and colleagues of the RIKEN Center for Brain Science recently published a compelling study in Nature Neuroscience. They showed in mice that increased neural activity in the claustrum mediates a global silencing of brain activity through resting state slow-waves.

Psilocybin likely subdues the so-called gate-keeper function of the claustrum, causing a loss of organized, constrained brain activity, according to neuroscientists Robin Carhart-Harris and Karl Friston. Such desynchronization increases connectivity between brain regions that are otherwise not engaged with one another, producing a change in consciousness.

Combined with supportive psychotherapy, such expansive, unconstrained cross-talk between brain regions is believed to help break habitual patterns of thinking and behavior, leading to psychological breakthroughs. This mechanism may also explain how psilocybin can affect positive change in such a wide variety of psychiatric conditions. Neuropsychopharmacologist David Nutt and colleagues of the Centre for Psychedelic Research at Imperial College London discuss these ideas in a paper published in Cell.

Einstein's music

Though anecdotal, Albert Einstein believed that his most profound scientific breakthroughs happened because he played the violin. He said this practice encouraged communication between different parts of his brain in unique ways that were otherwise inaccessible to his conscious mind. Is it possible that Einstein was describing a state of consciousness invoked by creative pursuits that mimic, albeit to a far lesser extent, the effect of psychedelics in the brain?

Barrett believes that listening to and playing music require a similar presence of mind to deep meditation — a connection to the here and now. Barrett says that “one of the unique anecdotal effects of psychedelics is said to be complete absorption in the present moment, and to this degree, I do believe that musical experiences can involve similar states of consciousness (albeit to a far lesser extent) to the effects of psychedelics.”

Regarding the role of the claustrum, Barrett adds that its function during musical experiences has not yet been studied. “Theoretically, this brain structure would be necessary for helping to coordinate brain states during musical experiences.” He points out that the claustrum would need to function like a highly controlled orchestra conductor in order to support musical experiences — unlike psychedelics, which undermine claustrum activity. “If musical experiences and psychedelic experiences both involve the claustrum” he says, “they may do so in very different ways.”

No drugs needed

Psychedelic-like experiences and altered states of consciousness can occur in the absence of mind-altering drugs. For example, sensory deprivation is known to trigger hallucinations. In fact, sensory deprivation therapy may help treat some of the same psychological disorders as psychedelic therapy, such as depression and anxiety. Given the claustrum’s role in integrating multisensory inputs, investigating its function in drug-free, psychedelic-like experiences may answer some intriguing questions in the future.

Barrett suggests that the claustrum probably plays a fundamental, yet different, role in all of these experiences: “Lack of sensory input may indeed lead to an imbalance in or disruption of the typical networks and circuits that are involved in claustrum function, however the mechanism by which this might happen is unclear.”

While we have yet to crack the code of human consciousness, incremental discoveries from different disciplines may stimulate scientific creativity and enable ongoing progress. Perhaps it is precisely such expansive, unconstrained communication between research areas that will lead us towards the most profound breakthroughs.


 
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The effects of psychedelics on the brain's "consciousness conductor"

by Rich Haridy | New Atlas

A new Johns Hopkins study, looking at how psilocybin influences a mysterious brain region called the claustrum, is just one of several compelling recent articles shining a light on how our brains generate our experience of consciousness.

In 2004, Francis Crick, one of the 20th century’s greatest scientific minds, died of colon cancer. Crick was best known for describing the structure of DNA in the 1950s with collaborator James Watson, but over the last couple of decades of his life his research focused on perhaps the biggest scientific question of them all: how does our brain generate what we consider to be consciousness?

The last paper Crick ever penned homed in on a small and still relatively mysterious brain region called the claustrum. Co-authored with Christof Koch, Crick was reportedly still editing the manuscript in hospital the day he died. Subsequently published in 2005, the paper presented a novel hypothesis - the claustrum may be key to our experience of consciousness, unifying and co-ordinating disparate brain areas to help generate our singular experience.

“The claustrum is a thin, irregular, sheet-like neuronal structure hidden beneath the inner surface of the neocortex in the general region of the insula,” wrote Crick and Koch in the landmark paper. “Its function is enigmatic. Its anatomy is quite remarkable in that it receives input from almost all regions of cortex and projects back to almost all regions of cortex.”

The extraordinarily unique way the claustrum connects different brain regions fascinated Crick. While some researchers had previously suggested the claustrum could potentially be the brain’s epicenter of consciousness, Crick and Koch presented a different analogy to describe the role of this mysterious brain region.

“We think that a more appropriate analogy for the claustrum is that of a conductor coordinating a group of players in the orchestra, the various cortical regions,” the pair wrote. “Without the conductor, the players can still play but they fall increasingly out of synchrony with each other. The result is a cacophony of sounds.”

It's like a highway

A new study, published in the journal Current Biology, is describing in unprecedented detail how the claustrum communicates with other brain regions. The project, an international collaboration between researchers in Sweden and Singapore, somewhat backs up Crick’s "consciousness conductor" hypothesis, revealing the claustrum is less like a singular hub for cortical inputs and more like a collection of specialized synaptic pathways connecting specific cortical regions.

“We found that the synaptic connectivity between the cortex and claustrum is in fact organized into functional connectivity modules, much like the European route E4 highway or the underground system,” says Gilad Silberberg, lead author on the study, from the Karolinska Institutet.

Another recent and even more focused study zoomed in on the claustrum’s role in coordinating slow-wave brain activity. A team from Japan’s RIKEN Center for Brain Science generated a transgenic mouse model in which they could artificially activate neurons in the claustrum through optogenetic light stimulation.
... it is so exciting that we are getting closer to linking specific brain connections and actions with the ultimate puzzle of consciousness. - Yoshohoro Yoshihara

The research discovered slow-wave activity across a number of brain regions increased in tandem with neural firing in the claustrum. Slow-wave brain activity is most often linked to a key period of sleep associated with memory consolidation and synaptic homeostasis.

“We think the claustrum plays a pivotal role in triggering the down states during slow-wave activity, through its widespread inputs to many cortical areas,” says Yoshihiro Yoshihara, team leader on the new RIKEN research. “The claustrum is a coordinator of global slow-wave activity, and it is so exciting that we are getting closer to linking specific brain connections and actions with the ultimate puzzle of consciousness.”

So, if increased claustrum activity seems to orchestrate a kind of synchronized slowing down of brain activity across a number of different cortical regions, what happens when claustrum activity is suppressed?

The claustrum under the influence of psychedelics

One hypothesis has suggested dysfunctional claustrum activity could play a role in the subjective effects of psychedelic drugs. One of the fundamental neurophysiological characteristics of a psychedelic experience is widespread dysregulation of cortical activity. Brain networks that don’t normally communicate will suddenly spark up connections under the influence of psilocybin or LSD. So a team from Johns Hopkins University set out to investigate exactly how psilocybin influences claustrum activity.

Due to the claustrum’s location in the brain its activity has traditionally been quite difficult to study in humans. However, a recently developed functional magnetic resonance imaging (fMRI) technique has afforded researchers a new and detailed way to measure claustrum activity. The Johns Hopkins study recruited 15 subjects to measure claustrum activity after either a placebo or a dose of psilocybin.

The study found psilocybin reduced claustrum neural activity between 15 and 30 percent. The overall reductions in claustrum activity also directly correlated with the subjective psychedelic effects of the drug.

More specifically, psilocybin seemed to significantly alter how the claustrum communicated with a number of brain regions fundamentally involved in attentional tasks and sensory processing. For example, under the influence of psilocybin, functional connectivity between the right claustrum and the auditory and default mode networks significantly decreased, while right claustrum connectivity with the fronto-parietal task control network increased.

“Our findings move us one step closer to understanding mechanisms underlying how psilocybin works in the brain,” says Frederick Barrett, one of the authors on the new study. “This will hopefully enable us to better understand why it’s an effective therapy for certain psychiatric disorders, which might help us tailor therapies to help people more.”

As Barrett suggests, this new insight into the effect psilocybin has on claustrum activity may shine a light on how this psychedelic drug generates its beneficial therapeutic effects. Psilocybin in particular has been found to be significantly useful in treating major depression and substance abuse disorders. The Johns Hopkins scientists hypothesize psilocybin’s action on the claustrum may play a key role in both the subjective effects of this psychedelic drug, and its beneficial therapeutic outcomes.

Further research is certainly necessary to verify this hypothesis, and the next step for the Johns Hopkins team will be to use this new claustrum imaging technique to investigate the brain region in subjects with a variety of psychiatric disorders. Fifteen years on from Francis Crick’s passing his final work is still inspiring new research. The new wave of psychedelic science, in tandem with novel neuroimaging techniques, brings us closer and closer to understanding how our brains create consciousness.

The new study was published in the journal Neuroimage.

Source: Johns Hopkins Medicine

 
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What psychedelic research can and cannot tell us about consciousness

by Anil Seth, Michael Schartner, Enzo Tagliazucchi, Suresh Muthukumaraswamy, Robin Carhart-Harris, Adam Barrett

It’s not easy to strike the right balance when taking new scientific findings to a wider audience. In a recent opinion piece, Bernard Kastrup and Edward F. Kelly point out that media reporting can fuel misleading interpretations through oversimplification, sometimes abetted by the scientists themselves. Media misinterpretations can be particularly contagious for research areas likely to pique public interest—such as the exciting new investigations of the brain basis of altered conscious experience induced by psychedelic drugs.

Unfortunately, Kastrup and Kelly fall foul of their own critique by misconstruing and oversimplifying the details of the studies they discuss. This leads them towards an anti-materialistic view of consciousness that has nothing to do with the details of the experimental studies—ours or others.

Take, for example, their discussion of our recent study reporting increased neuronal “signal diversity” in the psychedelic state. In this study, we used “Lempel-Ziv” complexity—a standard algorithm used to compress data files—to measure the diversity of brain signals recorded using magnetoencephalography (MEG). Diversity in this sense is related to, though not entirely equivalent to, “randomness.” The data showed widespread increased neuronal signal diversity for three different psychedelics (LSD, psilocybin and ketamine), when compared to a placebo baseline. This was a striking result since previous studies using this measure had only reported reductions in signal diversity, in global states generally thought to mark “decreases” in consciousness, such as (non-REM) sleep and anesthesia.

Media reporting of this finding led to headlines such as “First evidence found that LSD produces ‘higher’ levels of consciousness” (The Independent, April 19, 2017)—playing on an ambiguity between cultural and scientific interpretations of “higher”—and generating just the kind of confusion that Kastrup and Kelly rightly identify as unhelpful.

Unfortunately, Kastrup and Kelly then depart from the details in misleading ways. They suggest that the changes in signal diversity we found are “small,” when it is not magnitude but statistical significance and effect size that matters. Moreover, even small changes to brain dynamics can have large effects on consciousness. And when they compare the changes reported in psychedelic states with those found in sleep and anesthesia, they neglect the important fact that these analyses were conducted on different data types (intracranial data and scalp-level EEG respectively—compared to source-localized MEG for the psychedelic data)—making quantitative comparisons very difficult.

Having set up the notion that the changes we observed were “small,” they then say, “To suggest that brain activity randomness explains psychedelic experiences seems inconsistent with the fact that these experiences can be highly structured and meaningful.” However, neither we nor others claim that “brain activity randomness” explains psychedelic experiences. Our finding of increased signal diversity is part of a larger mission to account for aspects of conscious experience in terms of physiological processes. In our view, higher signal diversity indicates a larger repertoire of physical brain states that very plausibly underpin specific aspects of psychedelic experience, such as a blending of the senses, dissolution of the “ego,” and hyper-animated imagination. As standard functional networks dissolve and reorganize, so too might our perceptual structuring of the world and self.

“In short, a formidable chasm still yawns between the extraordinary richness of psychedelic experiences and the modest alterations in brain activity patterns so far observed.” Here, their misrepresentations are again exposed. To call the alterations modest is to misread the statistics. To claim a “formidable chasm” is to misunderstand the incremental nature of consciousness research (and experimental research generally), to sideline the constraints and subtleties of the relevant analyses and to ignore the insights into psychedelic experience that such analyses provide.

Kastrup and Kelly’s final move is to take this presumed chasm as motivation for questioning “materialist” views, held by most neuroscientists, according to which conscious experiences —and mental states in general—are underpinned by brain states. Our study, like all other studies that explore relations between experiential states and brain states (whether about psychedelics or not), is entirely irrelevant to this metaphysical question.

These are not the only inaccuracies in the piece that deserve redress. For example, their suggestion that decreased “brain activity” is one of the more reliable findings of psychedelic research is incorrect. Aside from the well-known stimulatory effects of psychedelics on the excitatory glutamate system, early reports of decreased brain blood flow under psilocybin have not been well replicated: a subsequent study by the same team using a different protocol and drug kinetics (intravenous LSD) found only modest increases in brain blood flow confined to the visual cortex. In contrast, more informative dynamic measures have revealed more consistent findings, with network disintegration, increases in global connectivity and increased signal diversity/entropy appearing to be particularly reliable outcomes, replicated across studies and study teams.

Consciousness science remains a fragile business, poised precariously between grand ambition, conflicting philosophical worldviews, immediate personal relevance and the messy reality of empirical research. Psychedelic research in particular has its own awkward cultural and historical baggage. Against this background, it’s important to take empirical advances for what they are: yardsticks of iterative, self-correcting progress.

This research is providing a unique window onto mappings between mechanism and phenomenology, but we are just beginning to scratch the surface. At the same time—and perhaps more importantly—psychedelic research is demonstrating an exciting potential for clinical use, for example in alleviating depression, though larger and more rigorous studies are needed to confirm and contextualize the promising early findings.

Kastrup and Kelly are right to guard against overplaying empirical findings by the media. But by misrepresenting the explanatory reach of our findings in order to motivate metaphysical discussions irrelevant to our study, they risk undermining the hard-won legitimacy of a neuroscience of consciousness. Empirical consciousness science, based firmly on materialistic assumptions, is doing just fine. And unlike alternative perspectives that place themselves “beyond physicalism,” it will continue to shed light on one of our deepest mysteries through rigorous application of the scientific method.

 
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Varieties of Ritual Involving States of Consciousness*

by Ralph Metzner | Journal of Wild Culture | 24 May 2022

A recent contributor to this journal, Ralph Metzner passed away on March 14, at 82. Well known for his controversial studies with Timothy Leary involving LSD at Harvard University, he went on to explore and write about expanded consciousness in many cultures and settings. This essay is his last long published essay. It speaks to what happens when we travel outside our willful, everyday selves, and what can we learn from such journeys, whether they be via the rigour of physical and mental practices or religious and spiritual inspiration, or through the opportunity provided by psychotropic substances for productive self-examination. A pioneer in research into psychedelic experiences and their outcomes, he explains how intentional, altered state journeys in the context of specific rituals can enhance our understanding of the human psyche's ability to heal itself.

The discovery of psychedelics and the kind of time-limited, yet profoundly altered states of consciousness they induced, has led to a significant re-examination and evaluation of all states of consciousness, both those ordinarily experienced by all, such as waking, sleeping and dreaming, and those less common, induced by such means as psychoactive drugs, hypnosis, shamanic drumming, certain kinds of breathing practices, and others. We recognize some altered states as generally positive, healthy, expansive, and associated with increased knowledge and moral value: this would include religious or mystical experience, ecstasy (lit. “ex-stasis”), transcendence, hypnotherapeutic trance, creative inspiration, tantric erotic trance, shamanic journey, cosmic consciousness, samadhi, nirvana, satori. And there are others generally considered negative, unhealthy, contractive, associated with delusion, psychopathology, destructiveness and even crime, such as depression, rage, psychosis, madness, hysteria, mania, dissociative disorders, substance addictions (alcohol, narcotics, stimulants) and behavioral addictions and fixations (sexuality, violence, gambling, spending). The notion of “altered states” can be considered one paradigm for the study of consciousness.

The research with psychedelic drugs that I participated in with colleagues Tim Leary and Richard Alpert at Harvard University in the early 1960s led to an increased awareness of the importance of intention in understanding states of consciousness. Leary formulated the “set-and-setting” hypothesis, according to which the content of a psychedelic experience is more a function of the intention (set) and the context (setting), than it is a matter of psychopharmacology, i.e., a “drug effect”. The drug is regarded as a trigger, or catalyst, propelling the individual into a different field or state of consciousness, in which the vividness and contextual qualities of sense perceptions are greatly magnified. Other catalysts could be certain foods, fasting, hypnotic inductions, sound, shamanic drumming, breathing (pranayama), trance dance, wilderness isolation, and so forth.

In 'dream incubation', a form of divination, one consciously formulates certain questions . . .

This hypothesis helps one to understand how it is possible that the very same drug, e.g., LSD, was studied and interpreted as a model psychosis (psychotomimetic), an adjunct to psychoanalysis (psycholytic), a treatment for addiction or stimulus to creativity (psychedelic), facilitator of shamanic spiritual insight (entheogenic); or even, as by the US Army and CIA, as a truth-serum type of tool for obtaining secrets fom enemy spies. Of the two factors of set and setting, set, or intention, is clearly primary, since the set ordinarily determines what kind of setting one will choose for the experience.

In my classes, 'Altered States of Consciousness', I have extended the set and setting hypothesis to all alterations of consciousness, no matter by what trigger they are induced; and even those states that recur cyclically and regularly, such as sleeping and waking. In the sleep-waking cycle of alterations of consciousness, internal biochemical events normally trigger the transition to sleeping or waking consciousness; but external factors may provide an additional catalyst. For example, lying in bed, in darkness, triggers changes in melatonin levels in the pineal gland, which in turn triggers falling asleep; and brighter light is normally the trigger for awakening, again meditated by cyclical biochemical changes. There may be, in addition, external factors such as stimulant or sedative drugs, or alarm clocks, which trigger those alterations.

Clearly, the content of our dreams can be analyzed as a function of set, internal factors in our consciousness during the day, as well as the environment in which we find ourselves. In fact, much of psychological dream interpretation is based on the assumption that dreams ofen reflect symbolic processing the prior day’s experiences, i.e., the intention. In dream incubation, a form of divination, one makes deliberate use of that principle, consciously formulating certain questions related to their inner process or outer situation, as one enters the world of sleep dreaming. In hypnotherapy, as in any form of psychotherapy, we always start with the intention or question that the client brings, using that to direct the movement into and through the trance state or the therapeutic session. In shamanic practice, whether with rhythmic drumming as the catalyst, or entheogenic plant concoctions, like ayahuasca, as the preferred method of the practitioner, one always comes initially with a question or intention. Even one’s experience in the ordinary waking state, such as that of the reader perusing this essay, is a function of the internal factors of intention or interest, and the setting where the reading is taking place.

Some researchers, notably Stanislav Grof, in his cartography of altered states, whether induced by psychedelics or by holotropic breathing, have categorized the different states by content, such as perinatal memories, identifications with animals or plants, experiences beyond the ordinary famework of time and space, and so on. Others, including myself, have taken a somewhat different approach, focussing on the energetics of altered states, apart fom content. It is possible to arrange different states of consciousness on a scale of arousal or wakefulness, fom high excitement to sleep or coma; as well as a separate, independent scale of pleasurable, heavenly states vs. painful, hellish states.

A third, purely formal or energetic dimension of altered states, irrespective of content, is expansion vs. contraction. Psychedelic drugs were originally called “consciouness-expanding”: in such states, one does not see hallucinated, illusory objects; rather, one sees the ordinary objects but, in addition, sees, knows and feels associated patterns and aspects that one was not aware of before. In such states, in addition to perception, there is apperception — the reflective awareness of the experiencing subject and understanding of associated elements of context. Another way of saying this is that an objective observer or witness consciousness is added to the subjective experiencing. This expanded awareness, or apperception of context, is generally absent in the psychoactive stimulants and depressants, which simply move consciousness either “up” or “down” on the arousal dimension, and away fom pain or discomfort. The observer witness consciousness is also notoriously absent in the addictive state induced by narcotics, which is typically described as “uncaring”, “cloudy”, or “sleep like.”

Returning for a moment to non-drug alterations of consciousness, we can see that waking up is an experience of expanded consciousness: I become aware of the fact that it is I who is lying in this bed, in this room, having just had this particular dream, and I become aware of the rest of the world outside, with all my relations of family and work, community and cosmos. To transcend means to “go beyond”; therefore, transcendent experiences — variously referred to in the spiritual traditions as enlightenment, awakening, ecstasy, liberation, mystical, cosmic, revelation — all involve an expansion of consciousness in which the previous field of consciousness is not ignored or avoided (we say, “that was only a dream”), but included in a greater context, providing insight.

I have argued, in an essay on “Addiction and Transcendence as Altered States of Consciousness,” that while psychedelic and other forms of transcendent experiences can be regarded as prototypical expansions of consciousness, the prototypical contracted states of consciousness are found in the fixations of addictions, obsessions, compulsions, and attachments. This opposition between them is implied when psychedelic drugs such as LSD and ibogaine are used in the treatment of alcoholism, drug addiction, and other forms of obsessional neurosis. For example, psilocybin, the extracted psychoactive principle of the Mexican sacred mushroom, is now again being tested in the treatment of OCD (obsessive-compulsive disorder).

RITUALS ASSOCIATED WITH DRUG CONSUMPTION

I propose the following definition of ritual: Ritual is the purposive, conscious arrangement of time, space, and action, according to specific intentions. In other words, going back to the research with psychedelics, we could say rituals are the conscious arrangement of set and setting. That’s why we had the different fameworks that were used (psychotomimetic, hallucinogenic, psycholytic, psychedelic, entheogenic) according to the predominant mind-set of the people arranging the experience. The particular drug used, LSD, was the same, which shows that the differing experiences were not due to different drug effects.

Young soldiers are taught, in symbolic ritual manoeuvers, how to immunize themselves against ordinary human impulses . . .

The consumption of our most popular psychoactive drugs, the depressant alcohol and the stimulant caffeine, is also surrounded by elaborate rituals, as we know well: the cocktail party, the college beer party, or the ritual brewing of the morning “wake-up” cup of coffee. Researchers in the field of heroin addiction have found that the typical addict is as dependent on the elaborate rituals of preparing for injection as he may be on the drug effect itself. Cigarette smokers, and people watching movies of smokers, know well that the little rituals of taking the cigarette out of the packet, the lighting of the cigarette, for oneself or for others — all seem to be essential elements of the experience that soothes anxiety, overcomes withdrawal distress, and strengthens the habit. One can always ask — what is the intention behind the ritual ingestion? In the case of cigarette smoking the intention appears to be to calm a stress reaction and give oneself a reward.

RITUALS OF EVERYDAY LIFE

We are all familiar with the common little rituals that punctuate transition phases of our everyday existence. In the mornings we have the rituals of the toilet and of cleaning, shaving, dressing and perhaps exercizing. At night time we have the bedtime rituals of putting on night-clothes, stories, prayers, good-night kisses. Parents with small children know how important it ofen is to the child that the exact same sequence of ritual elements is preserved, in order for the child to go peacefully to sleep.

The rituals associated with a family eating together are perhaps the oldest and most venerable in human life, going back to the paleolithic times, when hominid hunters brought back meat fom the hunt to share with the family and tribe. We know as well the rituals of the family meal, and students of family life have pointed out how important the family mealtime can be for the strengthening the family bonds. Or how significant they can be for the development of neurotic disturbances, especially eating disorders, where food ingestion and sharing becomes laden with all kinds of extra emotional baggage, and the taking of food nourishment becomes a substitute for missing emotional nourishment.

It’s not so much the biochemistry of the food and drink that causes difficulties, but the rituals of the family meal that come overlaid with hidden neurotic or power agendas.

Similarly, the activities of mating, sexuality, love, courtship, and marriage are all connected with numerous complex ritual behaviors, some prescribed by tradition and even religious teachings, others determined by glamorized images in novels and films.

Students of the Indian traditions of tantra and of the Chinese sexual teachings of Taoism have re-introduced these ancient teachings into modern life again — practices of ritualizing habitual sexual behavior and elevating to a spiritual practice in its own right — rather than, as is ofen the case in Western Christian-dominated societies, something that is contrary to spirituality. Mircea Eliade, in his work on yoga, referred to tantra as “ritualized physiology.”

INSTITUTIONALIZED RITUALS IN ACADEMIA, RELIGION AND THE MILITARY

Ritualized behavior in academic institutions like this university, are ubiquitous. Typically, in collective ritual activities, there are clearly defined roles for different people to play. For instance, there is the ritual known as the “university lecture,” in which one group of people, called “students,” sit in a more or less receptive mode, listening to an individual called “professor” expounding on a selected topic. The two roles, speaker and audience, carry differing but reciprocal intentions that bring them together into the same setting, at the same time.

Human behavior in church, synagogue or temple is highly ritualized, so much so that for many people the word “ritual” is synonymous with “religious ritual”. Religious rituals, it has ofen been pointed out, can become seemingly empty of meaning, just mechanical repetition of certain words, phrases and gestures. What has happened here? It is when the original spirit or intention behind the religious ritual — which undoubtedly had something to do with connecting with divinity — is no longer alive for those who are leading the rituals, who are therefore unable to convey that spirit to the others. It is as if the ritual form, or ceremonial form, has been emptied of spirit and people then feel bored or uninspired, not moved or uplifted. Some people seem to believe that all kinds of ritual are a good thing, and we need more of them in modern life. However, as can be seen in the example of religious ritual, the moral and social worth of ritual is a function of the intention behind the ritual.

Other areas of social life provide even more dramatic examples of the moral neutrality of ritual. There are rituals of destructiveness and aggressions — ranging all the way fom the ritualized aggression of sports like boxing or football; the fetishistic rituals of sado-masochism and bondage/domination in the sexual arena; to the elaborately choreographed rituals of criminal investigation, policing, the judiciary and the court-room trial; and the dehumanizing training rituals of the military. Young soldiers are taught, in symbolic ritual manoeuvers, how to immunize themselves against ordinary human impulses of decency and kindness, in order to become more ruthless fighting machines or robots. As is well-known, the Nazis were masters of ritual, using the power of uniformed masses of men, with torchlights, songs, marches and propaganda speeches, to accumulate and harness the human energy of zealous devotion to a cause or party for their own in-group economic and power agendas.

HEALING AND THERAPEUTIC RITUALS IN WESTERN MEDICINE & INDIGENOUS SHAMANISM

The ritual aspects of medicine and psychotherapy are well-known and obvious. The practice of medicine is not just the mechanical delivery of drugs or surgery. The way that treatment is presented, whether the physician regards his patient with respect or with condescension, qualities of empathic support and human kindness — are all recognized to be essential elements of the totality of treatment. Good medical training schools will emphasize the importance of a therapeutic “bedside manner” for successful therapeutic outcomes. The holistic medicine movement, in part inspired by Eastern medical traditions such as Chinese, Indian and Tibetan medicine, will consider all aspects of life-style, including diet, exercise, emotional stress, family dynamics and even astrological factors, as part of the overall picture of illness and recovery. These are all aspects of the time and space arrangements, the set and the setting of the interaction between physician and patient.

In the field of psychotherapy, the significance of the contextual ritual is also well appreciated. Psychoanalysis was sometimes called the “talking cure”, but actually, in the writings of Sigmund Freud and his successors, the psychoanalytic healing ritual involved much more than talking. The psychoanalyst sits behind the patient, who is lying on a couch; the latter is instructed to consider the analyst a “blank screen” to which he can communicate his “free associations” — free, that is, of the analysts potentially distracting appearance. One of Freud’s most brilliant and innovative students, Wilhelm Reich, broke with that tradition and invented his own very different therapeutic ritual: facing the patient and observing the breathing movements of his body, he could connect those to psychic content, reading the pattern of muscular tensions he called the “character armor.”

More generally, the importance of a warm, comfortable, safe, aesthetically pleasing setting and empathic manner of the therapist is widely appreciated. These are all factors of ritual, believed to be and chosen to be conducive to positive therapeutic outcomes.

If we compare how Western medicine and psychotherapy have incorporated psychedelic substances into healing practice, with the shamanic healing ceremonies involving entheogenic plant substances, a perception of the importance of ritual is inescapable. The traditional shamanic ceremonial form involving hallucinogenic plants is a carefully structured experience, in which a small group (6-12) of people come together with respectful, spiritual attitude to share a profound inner journey of healing and transformation, facilitated by these powerful catalysts. A "journey" is the preferred metaphor in shamanistic societies for what we call an "altered state of consciousness.”

There are three significant differences between shamanic entheogenic ceremonies and the typical psychedelic psychotherapy. One is that the traditional shamanic rituals involve very little or no talking among the participants, except perhaps during a preparatory phase, or afer the experience to clarify the teachings and visions received. The second is that singing, or the shaman's singing, is invariably considered essential to the success of the healing or divinatory process. Furthermore, the singing typical in etheogenic rituals usually has a fairly rapid beat, similar to the rhythmic pulse in shamanic drumming journeys (widespread in shamanistic societies of the Northern Hemisphere in Asia, Europe, and America). Psychically, the rhythmic chanting, like the drum pulse, seems to give support for moving through the flow of visions and minimize the likelihood of getting stuck in fightening or seductive experiences. The third distinctive feature of traditional ceremonies is that they are almost always done in darkness or low light — which facilitates the emergence of visions. The exception is the peyote ceremony, done around a fire (though also at night); here participants may see visions as they stare into the fire.

I will briefly mention some of the variations on the traditional rituals involving hallucinogens. In the peyote ceremonies of the Native American Church, in North America, participants sit in a circle, in a tipi, on the ground, around a blazing central fire. The ceremony goes all night and is conducted by a "roadman", with the assistance of a drummer, a firekeeper and a cedar-man (for purification). A staff and rattle are passed around and participants sing the peyote songs, which involve a rapid, rhythmic beat. The peyote ceremonies of the Huichol Indians of Northern Mexico also take place around a fire, with much singing and story-telling, afer the long group pilgrimage to find the rare cactus.

The ceremonies of the San Pedro cactus [Echinopsis pachanoi (syn. Trichocereus pachanoi)], in the Andean regions, are sometimes also done around a fire, with singing; but sometimes the curandero [healer or 'medicine man'] sets up an altar, on which are placed different symbolic figurines and objects, representing the light and dark spirits which one is likely to encounter.

The mushroom ceremonies (velada) of the Mazatec Indians of Mexico, involve the participants sitting or lying in a very dark room, with only a small candle. The healer, who may be a woman or a man, sings almost uninterruptedly, throughout the night, weaving into her chants the names of Christian saints, her spirit allies, and the spirits of the Earth, the elements, animals and plants, the sky, the waters and the fire.

Traditional Amazonian Indian or mestizo ceremonies with ayahuasca also involve a small group sitting in a circle, in semi-darkness, while the initiated healers sing the songs (icaros), through which the healing and/or diagnosis takes place. These songs also have a fairly rapid rhythmic pulse, which keeps the flow of the experience moving along. Shamanic "sucking" methods of extracting toxic psychic residues or sorcerous implants are sometimes used.

The ceremonies involving the African iboga plant, used by the Bwiti cult in Gabon amd Zaïre, involve an altar with ancestral and deity images, and people sitting on the floor with much chanting and some dancing. Ofen, there is a mirror in the assembly room, in which the initiates may "see" their ancestral spirits.

In comparing Western psychoactive-assisted psychotherapy with shamanic entheogenic healing rituals, we can see that the role of an experienced guide or therapist is equally central in both, and the importance of set (intention) and setting is implicitly recognized and articulated into the forms of the ritual. The underlying intention in both practices is healing and problem resolution. Therapeutic results can occur with both approaches, though the underlying paradigms of illness and treatment are completely different. The two elements in the shamanic traditions that pose the most direct and radical challenge to the accepted Western worldview are the existence of multiple worlds and of spirit beings; such conceptions are considered completely beyond the pale of both reason and science, though they are taken for granted in the worldview of traditional shamanistic societies.

In both traditional and neo-shamanic practices and ceremonies, there are two main kinds of intention or purpose that are either implicit or often explicitly recognized . . .

It is worth mentioning that in the case of ayahuasca, there have grown in Brazil three distinct syncretic religious movements or churches, that incorporate the taking of ayahuasca into their religious ceremonies as the central sacrament. Here the intention of the ritual is not so much healing or therapeutic insight, as it is strengthening moral values and community bonds. The ceremonial forms here resemble much more the rituals of worship in a church than they resemble either a psychotherapist’s office or a shamanic healing session.

There are also several different kinds of set-and-setting rituals using hallucinogens in the modern West, ranging fom the casual, recreational "tripping" of a few fiends to "rave" events of hundreds or thousands, combining Ecstasy (MDMA) with the continuous rhythmic pulse of techno music. My own research has focussed on what might be called neo-shamanic medicine circles, which represent a kind of hybrid of the psychotherapeutic and traditional shamanic approaches. In the past twenty years or so I have been a participant and observer in over one hundred such circle rituals, in both Europe and North America, involving several hundred participants, many of them repeatedly. Plant entheogens used in these circle rituals have included psilocybe mushrooms, ayahuasca, San Pedro cactus, iboga and others. My interest has focussed on the nature of the psychospiritual transformation undergone by participants in such circle rituals.

In these hybrid therapeutic-shamanic circle rituals certain basic elements fom traditional shamanic healing ceremonies are usually, though not always, kept intact:

• the structure of a circle, with participants either sitting or lying;
• an altar in the center of the circle, or a fire in the center if outside;
• presence of an experienced elder or guide, sometimes with one or more assistants;
• preference for low light, or semi-darkness; sometimes eye-shades are used;
• use of music: drumming, rattling, singing or evocative recorded music;
• dedication of ritual space through invocation of spirits of four directions and elements;
• cultivation of a respectful, spiritual attitude.

Experienced entheogenic explorers understand the importance of set and therefore devote considerable attention to clarifying their intentions with respect to healing and divination. They also understand the importance of setting and therefore devote considerable care to arranging a peaceful place and time, filled with natural beauty and fee fom outside distractions or interruptions.

Most of the participants in circles of this kind that I have observed were experienced in one or more psychospiritual practices, including shamanic drum journeying, Buddhist vipassana meditation, tantra yoga and holotropic breathwork and most have experienced and/or practiced various forms of psychotherapy and body-oriented therapy. The insights and learnings fom these practices are woven by the participants into their work with the entheogenic medicines. Participants tend to confirm that the entheogenic plant medicines, when combined with meditative or therapeutic insight processes, function to amplify awareness and sensitize perception, particularly amplifying somatic, emotional and instinctual awareness.

Some variation of the talking staff or singing staff is ofen used in such ceremonies: with this practice, which seems to have originated among the Indians of the Pacific Northwest, and is also more generally now referred to as "council", only the person who has the circulating staff sings or speaks, and there is no discussion, questioning or interpretation (as there might be in the usual group psychotherapy formats). Some group sessions, however, involve minimal or no interaction between the participants during the time of the expanded state of consciousness.

In preparation for the circle ritual, there is usually a sharing of intentions and purposes among the participants, as well as the practice of meditation, or sometimes solo time in nature, or expressive arts modalities, such as drawing, painting or journal work. Afer the circle ritual, sometimes the morning afer, there is usually an integration practice of some kind, which may involve participants sharing something of the lessons learned and to be applied in their lives.

RITUALS OF DIVINATION, TRANSITION AND INITIATION

In both traditional and neo-shamanic practices and ceremonies, there are really two main kinds of intention or purpose that are either implicit or, often, explicitly recognized — i.e., healing or problem solving, which usually involve dealing with the past; and seeking guidance or vision, which involve looking at the future. One could say the overall purpose is divination — divination in relationship to healing is called diagnosis, or seeking the cause of the difficulty. Western medicine and psychotherapy also looks to the past for understanding the causal factors in illness or psychological difficulty: we ask where and how did the wounding, germ, microbe, virus, infection, or familial relationship difficulty begin? Shamanistic healers, for example in South America, are likely, in about 50% of cases, to attribute the origin of both physical and psychic disorders, to sorcery — so the question becomes by whom and how did this hexing take place? Accurate causal diagnosis is recognized as being necessary to determine appropriate and effective treatment or cure. (There are exceptions to this practice: the most striking example is homeopathy, which merely looks at the pattern of currently manifesting symptoms).

Divination of the future is not generally practiced in Western medicine or psychiatry, except in the somewhat attenuated form that we call prognosis in medicine.

However, academics, business people, and politicians in the modern world, devote considerable energy and resources to determining future trends and probabilities. Terms such as forecasting, scenario making, computer modeling, trend projections — all indicate a profound interest in probable future possibilities. Terms such as foresight and forethought are perhaps the terms most commonly used to describe looking into the future. The profession of psychotherapy has closed itself off fom looking into their clients’ future, largely, I believe, because of an underlying belief that the future can’t be predicted. But this rests on a confusion of foresight with prediction: people practicing future guidance seeking to know the future is probabilistic, not determined, like the past.

One of the ways the newly emerging profession of coaching is distinguishing itself fom traditional psychotherapy by being more concerned with helping clients clearly articulate their intentions for the future and helping them realize them.

Among ordinary people in the Western industrialized nations and even more in Third World countries, it is understood that divination is not like prediction, and at the same time it is understood that the choices we make in the present are greatly influential in bringing about the kind of future we envision. For most people, the term “divination” is associated with systems such as astrology, the I Ching, the Tarot, runes, stones, bones, etc. These may be regarded as divination accessories or tools. If we examine the basic common factor in all these methods is the asking of a question (or stating an intention) which then guides the diviner’s or psychic’s attention and perception. Just as the client’s question or intention determines the course of the psychotherapists or physicians interventions. The practices that I have developed over the past several years I call “alchemical divination” because their focus is on psychospiritual transformation, as symbolized in alchemical language and symbolism. They can be equally applied to past issues and questions of healing, as well as future issues of seeking a vision or guidance for one’s life. These practices are rituals, in their formalized structure of question-and-answer processes, whether done with individuals or in groups. The steps of the ritual, one might say, is purely internal, like a kind of meditation; but the format is similar to what one would expect to see with a Tarot card reader, or crystal ball gazer, or astrologer, where another, presumably neutral person, who presumably is not as overanxious about some outcomes and, and therefore “seeing” with more clarity and less bias.

There are certain differences in shamanic and alchemical divination practices oriented toward the future, fom the kinds of approach to forecasting used by futurists in academia or the business world. Whereas the latter use purely rational, mental processes and statistics to anticipate future trends, shamanic (and by extension alchemical, since alchemy is an outgrown of shamanism) methods usually involve some kind of altered state method, to bring the questioner and/or the diviner into an expanded or heightened state of consciousness, also called “non-ordinary consciousness”, where they can glimpse into the world beyond the here-and-now reality of the ordinary senses.

The seeking of guidance or a vision for one’s life was an essential core element of the passages of adolescence in traditional societies, especially among native North American Indians. The Plains Indians, such as the Sioux, would have their young boys spend several days on a “vision quest” in the mountains or wilderness, fasting and praying for a vision for their life. There would be extensive preparation beforehand and integration aferward by a tribal or familial elder. In recent years the practice of vision question or fasting alone in the wilderness seeking a vision has been brought to many people at various transition points in their life, not only adolescence — transitions such as divorce, job changes, major deaths or losses in the family and so on. One seeks to connect with inner sources of spiritual guidance, and ofen healing as well.

Rites of passage with a spiritual focus have for a long time been absent in the modern world. They’ve been preserved only in very attenuated and simplistic forms such as the rites of confirmation and bar mitzvah in religious communities, which for many adolescents don’t carry much spiritual meaning anymore. Or they may be found, also in greatly desacralized form, in college faternities, and high school graduation ceremonies. Or they may be found, for males especially, in the brutal violence of military boot-camp training, or of street-level gang initiations. Therefore, the re-introduction of such transition rites or rites of passage, like the vision quest. into modern society represents a reconnection to the archaic life-wisdom practices of the ancient world and of indigenous societies and as such presages the possibility of greatly deepened community and social cohesiveness and health.

*From the article (including references) here :
 
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Psychedelics permanently alter our understanding of consciousness, study*

by Eric Schank | Salon | 20 Apr 2022

Those who have experimented with psychedelics often describe a sensation of connectedness with objects around them, things like rocks, trees, or rivers. Sometimes the "connectedness" is more literal, as high doses of psychedelic drugs like LSD may cause users to believe the walls are talking to them.

Now, researchers have found that a single psychedelic experience can leave users with enduring cognitive changes. Following a "trip," many subjects assigned higher levels of consciousness to both living and non-living things alike.

To be clear, the study, published in Frontiers in Psychology, was a survey of psychedelic users, and did not actually administer drugs to its subjects. Participants simply displayed a shift in beliefs. Their revelations post-psychedelic use were not of the superstitious variety, but rather represented a philosophical attitude change. These impacts persisted with survey respondents reporting an average of eight years after the experience in question.

"This study demonstrates that when beliefs change following a psychedelic experience, attributions of consciousness to various entities tend to increase," Dr. Sandeep Nayak stated in a news release on the study, which was colorfully titled "A Single Belief-Changing Psychedelic Experience Is Associated With Increased Attribution of Consciousness to Living and Non-living Entities."

Following particularly profound experiences during usage of psilocybin, mescaline, ayahuasca, LSD, DMT, or other hallucinogenic drugs proceeded a marked impact on the very concept of consciousness. Indeed, only 26 percent of participants attributed consciousness to plants prior to their psychedelic experience; afterwards, that number jumped to 61 percent. The jump for fungi was comparable. One category surveyed was "inanimate natural objects"; researchers found that 8 percent of users did not believe such objects were conscious prior to their experience, while after taking psychedelics, 26 percent did.

Though participants displayed high belief in the consciousness of non-human primates and four-legged animals, the respective shifts — from 63 percent to 83 percent and 59 percent to 79 percent — were smaller than those for other entities. (Notably, both non-human primates and four-legged animals were already considered to possess consciousness by the majority.)

Interestingly, those attributing such cognitive abilities to inanimate objects were in the minority, but a majority demonstrated attribution of consciousness to non-human beings. Relatedly, psychedelics users have been shown to exhibit more environmentally conscious behaviors.

"It's not clear why, whether that might be an innate drug effect, cultural factors or whether psychedelics might somehow expose innate cognitive biases that attribute features of the mind to the world," Nayak added.

Such studies may evoke an eye roll and, perhaps, memories of college students discussing the merits of "stoned ape theory" over a blunt. For the unfamiliar, that hypothesis suggested hallucinogens, specifically "magic" mushrooms, spurred the evolution of human consciousness.

Still, the social ramifications engendered by taking psychedelics have alarmed state security apparatuses, historically speaking. The criminalization of LSD in the United States in 1968 was in part a reaction to the idea that the drug stimulated its users to be anti-war and anti-establishment; Governor Edmund Brown of California famously said that it "poses a growing threat to society." Likewise, the counterculture seemed to believe that LSD could change one politics', too: Grace Slick of Jefferson Airplane plotted to dose President Richard Nixon with LSD during a White House visit in 1970.

In any case, there are numerous psychological and evolutionary theories as to how humans develop a sense of other things as conscious.

"Considering attribution of consciousness and the problem of other minds from an evolutionary perspective, the capacity for detecting and attributing agency has self-evident survival value, for instance in the detection of predators," the study reads. "Thus, innate cognitive biases may partially underpin tendencies to attribute mentality to entities without brains. Interestingly, studies suggest that that wide attribution of consciousness may be developmentally normal in children and subsequently suppressed or unlearned."

A postdoctoral fellow in psychiatry at Johns Hopkins Center for Psychedelic and Consciousness Research, Nayak co-authored the paper with Dr. Roland Griffiths, founding director of the research center. Nayak primarily investigates the potential treatment of psychiatric conditions with these poorly understood substances. Promising studies, including those of Nayak, have indicated treatment of addiction, depression, anxiety, and PTSD may be particularly useful applications.

"The results suggesting that a single psychedelic experience can produce a broad increase in the attribution of consciousness to other things, raises intriguing questions about possible innate or experiential mechanisms underlying such belief changes," Griffiths stated in the news release. "The topic of consciousness is a notoriously difficult scientific problem that has led many to conclude it is not solvable."

Inquiry into consciousness has perplexed our greatest minds since before the conception of science itself. At best, our definition of consciousness is hazy. Determination of consciousness in other organisms remains nearly impossible to determine, but under the current paradigm of cognitive sciences, no evidence supports such notions.

Phenomenal consciousness, which the study described as essentially an awareness of the state of existence, could be the root of the phenomenon. The use of psychedelics, researchers suggest, enhances the effect of phenomenal consciousness itself. Attribution of consciousness to others seems to appear as a side effect, but research is lacking.

Emerging from a decades-long dark age for psychedelics research, a proto-renaissance in the field abounds. Studies have poured out of institutions as regulations weaken, offering further counters to schedule I classification of hallucinogens and other psychedelics.

Likewise, psychedelic legalization efforts have begun to snowball following decriminalization in Oregon, Denver, Oakland, Santa Cruz, and smaller municipalities. Similar decriminalization efforts have entered the arena of state legislation this year along with a continuous trickle of cannabis legalizations, with one decriminalization bill having been passed in the US House.

*From the article here :
 
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