Codeine is an
opiate and
prodrug of
morphine used to treat
pain,
coughing, and
diarrhea. It is found naturally in the sap of the
opium poppy,
Papaver somniferum.
*It is typically used to treat mild to moderate degrees of pain.
*it is metabolized by CYP2D6 do morphine ( 5-10, maybe 15 percent of ingested dose, according to your genotype), by CYP3A4 to norcodeine and by UGT2B7 to glucuronides of codeine, norcodeine, and morphine
*it has elimination half-life of about 3 hours, duration of action 3-6 hours
*it can be VERY itchy, warm and generally sedating
*onset of action approximately 1 hour(30-120minutes)
*bioavailability of oral ROA ~90%
Tramadol is an
opioid pain medication used to treat moderate to moderately severe pain.
* metabolized by CYP2D6 to its main opiod-active metabolite O-desmethyltramadol, by CYP3A4 to N-desmethyltramadol.
* it acts as an SERORONINE-NOREPINEPHRINE reuptake inhibitor, which every metabolite and enenatiomer shares different SRI or NRI potency. It also has many different actions such as weak NMDA receptor antagonist etc.
* Its bioavailability is approximately 75 percent but raises if u ingest it in a way of staggering your doses.
* Its half-life 6.3 ± 1.4 also increase with dose staggering.
* Generally much longer acting, less sedating (sometimes even stimulant) than codeine but it also has some itching-potential.
* Onset of action is most of the time lomger than codeins, full effects at 2-3 hours.
* Not recommended to dose more than 100mg at once and more than 400mg daily because of higly increased risk of (very unpleasant and dangeroes) seizures.
* Antidepressant-like activity (instant)
* More prove to nausea than codeine...
Not sure if i forgot somthing..they are both casually combined with paracetamol so be careful, spread your doses (mainly with tramadol) and u will also spare your liver.