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cocaine vs lidocaine numbing properties?

IAMTHOUGHTS

IAMTHOUGHTS

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Jul 17, 2006
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I know there are a lot of chemistry people in here...

can anyone tell me if cocaine and lidocaine have physically different numbing effects when taken nasally.

for example if i had 3 samples of "coke" that felt about equal in strength.

can anyone make any scientific sense of this.

#1 not much numbing still good quality

#2 will numb the teeth ONLY on the side of my face that i sniffed from.

#3 will numb my top teeth all the way across, both sides, even with one rip.

maybe im just dumb?....
 
Not so much the numbing effects, but more other issues. Cocaine also causes vasoconstriction which slows it's passage into the main circulatory system; lignocaine has no vasoconstriction properties so it all gets absorbed pretty quickly - possibly quick enough to give plasma levels that destabilize cardiac function ie go directly to hospital, do not pass go, do not collect £200
 
SO are you saying if i sniffed coke cut with lidocaine I would be in the hospital?

or the different numbing effects i have noticed are not any type of indication of weather my coke is cut with lidocaine or not?

im just wondering why different coke that seems about equal can have completely different numbing proporties....
elaborate?
 
Is this to cut your coke with to rip ppl off with?
 
Im *pretty* sure that purer cocaine doesnt numb the nose as much as people think and other numbing agents give much more of a numbing sensation so if your coke numbs your like never before then its robably cut with lidocaine.

Please dont cut your coke with any if that shit. theres enough crappy coke around we dont need any more. If you were in Australia and I found out you cut my coke you could be severely hurt. For the prices we pay it'd wanna be damn good shit otherwise theres going to be trouble.

Anyway back onto the point.

Alot of my friends will go "My favourite part of coke is that it numbs the fuck outta my face" and half the time I thing...Should the best part of coke be the high?? WTF. I heard a mate was EATING coke the other day. they must be getting speed cut with novo/lidocaine, plus they sell it for $30 a point, noone around here that sells the goods sells points, its all grams and eightballs, youd be lucky to get half a gram.. Who the fuck eats coke and who told them to, ive heard that twice now and supposedly it lasted them ages which is a sure tell sign of meth. Some people should just stay away from drugs and keep it to the people with half a brain.

Dont cut your gear and coke doesnt numb the whole face most of the time unless its insanely pure which is unlikely. If it numbs your face and lasts for any longer than 45 minute to an hour then its cut with meth an one of the medical numbing agents.
 
Usually when we do it, which I've done like 2 times, lol, my friend who is more into it than I will take a bit and rub it in his mouth, and he always sucks the drips into his mouth and like, swishes it around, I don't see the point, I kinda prefer the confidence boost and fun creating effects more than a bit of numbness, lol, if I wanna be numb I'll take K and my whole body can be numb, not just a small part of my face, haha.
 
IAMTHOUGHTS said:
can anyone tell me if cocaine and lidocaine have physically different numbing effects when taken nasally.
Click to expand...

afaik they work through the same mechanism (blocking voltage-gated Na+ channels). so differences are only due to differences in concentration and distribution in the tissue (i'd guess the latter would not amount to much. maybe lidocaine would cause broader numbness than cocaine, as it's not a vasoconstrictor.)
 
to everyone above, im not cutting coke i wanna know what the deal is with the shit i buy is.


thank you. that is really all i wanted to know.
so a high nimbing effect could be caused by high levels of coke or lidocaine... im guessing the shit i buy doesnt have high levels of coacaine :\ so the stuff that numbs my teeth real hard is prob cut with lidocaine, or thats my guess.
Black said:
afaik they work through the same mechanism (blocking voltage-gated Na+ channels). so differences are only due to differences in concentration and distribution in the tissue (i'd guess the latter would not amount to much. maybe lidocaine would cause broader numbness than cocaine, as it's not a vasoconstrictor.)
Click to expand...
 
real coke will numb you but i wont do it quickly, it will be a gradual thing and should be accompanied by intense euphoria and massive ego boost. the numbing should be the secondary thing you notice compared to the euphoria and positive body high
 
SO are you saying if i sniffed coke cut with lidocaine I would be in the hospital?
Click to expand...


No only if you sniffed lidocaine with no vasoconstrictor, like cocaine also in there
 
the_ketaman said:
Alot of my friends will go "My favourite part of coke is that it numbs the fuck outta my face" and half the time I thing...Should the best part of coke be the high?? WTF.
Click to expand...

Pavlovian effect. Everybody needs a happy thought or association to set them off. Be it meth and porn or coke and the freeze it brings with itself. IV'ers of coke like the ringer, snorters like the numb/freeze. etc.
 
SO are you saying if i sniffed coke cut with lidocaine I would be in the hospital?

or the different numbing effects i have noticed are not any type of indication of weather my coke is cut with lidocaine or not?
Click to expand...

Unless the coke precipitated a run of Vtac- the lidocaine might end up causing you to convert back into a benign rhythm.
 
As a used to be user of cocaine I will say I had a bad batch or two cut with lidocaine and for one it doesn't get you high like cocaine forget about it a real user will know right away, and for two your nose will run badly very fast after taking and for three numbing is minimal compare to cocaine totally different and in fact scary after reading some of the effects of lidocaine, shit pisses me off that people would even cut there product with it, and as a side note defiantly absorbs quickly and high barely last but for 15 min max, and I use to do one after another especially when noting really seemed to be happening bottom line dangerous and for days after extremely tired had headaches and fatigue not a fan at all and I was a heavy user when I used which was maybe once a month maybe twice .. my advice stay away from all drugs cost a nut and screws your system up even for a 245 pound Irishman like myself.
 
The IC50 of cocaine for it's Na+ inhibition of influx to sodium channels is 6.99 ± 2.43 (using vertridine as standard), where as lidocaine is weaker, with 39.6 ± 2.4 in IC50. Source
 
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