I was at the ER a while back and they gave me scripts for both upon my discharge. No one ever made a point of telling me to not take them together, and if I wasn't supposed to do so, I'm sure they would have made a point of telling me so. I'm not sure if the fact that the Clonodine was a patch and Zofran was a pill makes any difference. BTW, the Clonodine really helped with some of my W/D symptoms but I never got nauseous enough to use the Zofran. Anyway, bottom-line is that I'm pretty sure they can be taken together.