Benzos clarithromycin and Valium

[Soul11]

curruntly on 1000mg a day for 1 week regiment, will taking around 50-60mg valium at once and clarithromycin will be safe ?

 

[deficiT]

curruntly on 1000mg a day for 1 week regiment, will taking around 50-60mg valium at once and clarithromycin will be safe ?

Clarithromycin | Side Effects, Dosage, Uses & More

Clarithromycin oral tablet (Biaxin) is used to prevent and treat certain bacterial infections. Learn about side effects, warnings, dosage, and more.

www.healthline.com

From what I've read the only thing you would have to worry about is an increase in sedation.

 

[Soul11]

Clarithromycin | Side Effects, Dosage, Uses & More

Clarithromycin oral tablet (Biaxin) is used to prevent and treat certain bacterial infections. Learn about side effects, warnings, dosage, and more.

www.healthline.com

From what I've read the only thing you would have to worry about is an increase in sedation.

some people says it could bring serious side effect such as if you take it with Lorazepam like this thread- https://bluelight.org/xf/threads/urgent-advice-on-drug-interaction-risk-benzos.830589/

i was also under impression that taking high does of valium such as 50-60mg also raises clarythromycin as well

 

[deficiT]

some people says it could bring serious side effect such as if you take it with Lorazepam like this thread- https://bluelight.org/xf/threads/urgent-advice-on-drug-interaction-risk-benzos.830589/

i was also under impression that taking high does of valium such as 50-60mg also raises clarythromycin as well

Oh I see. Yeah, if that's the case maybe you need to watch out for that interaction.

 

[Snafu in the Void]

curruntly on 1000mg a day for 1 week regiment, will taking around 50-60mg valium at once and clarithromycin will be safe ?

clarithromycin (and other antibiotics) is a powerful inhibitor of enzyme CYP3A4

the increased sedation is likely due to this inhibition which causes higher blood concentration and increased duration of diazepam

it's generally safe combo as long as you are tolerant to that much diazepam, but you should expect increased sedation and amnesia... so don't drive anywhere and stay home

I don't believe they interact any other way, but I am not expert