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cigarettes and changes in blood level of xanax and methadone

Im interested in these studies as as far as I know, tobacco smoke induces primarily cyp 1a1, 1a2, and 2e1 (I believe) with 1a2 having the most interactions. Drugs like clozapine, fluvoxamine and some methylxanthines are the primary drugs affected but alprazolam seems to have a PK interaction with tobacco of which I do not know the mechanism. There is a lot of shit in tobacco smoke though, so I wouldnt be surprised.
 
Purely anecdotal of course, but since I quit smoking cigarettes a few months ago I feel like benzos (mainly clonazepam) affect me a lot more. Again, that's just my experience, but figured I'd put it out there.
 
http://www.ncbi.nlm.nih.gov/pubmed/10427467
Cigarette smoking is associated with a lesser magnitude of blood pressure and heart rate lowering during treatment with beta-blockers, less sedation from benzodiazepines and less analgesia from some opioids, most likely reflecting the effects of the stimulant actions of nicotine.
In animal studies, nicotine induces the activity of several enzymes, including CYP2E1, CYP2A1/2A2 and CYP2B1/2B2, in the brain, but whether this effect is clinically significant is unknown.
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http://www.ncbi.nlm.nih.gov/pubmed/6883942
During the multiple-dose phase, mean plasma concentrations were 15-30% lower in the smokers. Total body clearance of alprazolam was 24% greater and the apparent volume of distribution was 17% less in smokers. The elimination half-life was 49% greater in nonsmokers. These differences were not significant. Changes were not observed in elimination half-life or clearance after alprazolam cessation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778224/
Our findings demonstrated no statistically significant differences in GABAA-BZR availability in smokers compared to nonsmokers.
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http://www.ncbi.nlm.nih.gov/pubmed/3155675
In non-smoking vs smoking subjects, there was no significant difference in mean clearance of diazepam (0.44 vs 0.47 ml/min/kg), midazolam (9.6 vs 7.1 ml/min/kg), or lorazepam (0.96 vs 1.08 ml/min/kg).
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I smoke a lot of cigarettes, and whenever I take Xanax without a tolerance it wears off really fast.
 
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