5C-AKB-48 just recently appeared on the Swedish RC market. That's the 5-chloropentyl analog of AKB-48. Probably a potent CB1 agonist yes, but a primary halide with not much steric bulk makes me a bit worried.
What in your opinion are the chance of these to covalently bind to receptors (or anything for that matter)? Can chlorides be assumed to be safe in comparison to bromides and iodides which I feel confident would alkylate? Is there a chance that the nitrogen on the second position could facilitate in the SN2-displacement (a la nitrogen mustard style) or are the free electrons too delocalized in the aromatic system to be nucleophilic? It would follow Baldwin's rules with 7-exo-tet which is favored.
What in your opinion are the chance of these to covalently bind to receptors (or anything for that matter)? Can chlorides be assumed to be safe in comparison to bromides and iodides which I feel confident would alkylate? Is there a chance that the nitrogen on the second position could facilitate in the SN2-displacement (a la nitrogen mustard style) or are the free electrons too delocalized in the aromatic system to be nucleophilic? It would follow Baldwin's rules with 7-exo-tet which is favored.