Harm Reduction buspirone and serotonin syndrome?

[attention_horror_621]

i take 5mg buspirone twice a day, ik it effects serotonin and im wondering if this could lead 2 serotonin syndrome and the like if i do other shit that day. ive done DXM while on buspirone and i was totally fine but idk. just wanna see if its something that should concern me. and if so, how long should i b off buspirone b4 i do shit like dxm?

 

[Snafu in the Void]

It's possible. Buspirone significantly increases free serotonin in the brain.

You mean you take 5mg of buspirone?

Overall I would advise not to frequently abuse DXM or use very high doses. Even by itself it can cause psychosis or permanent damage.

But if you do, I would not take buspirone for 1-2 days before DXM. Unlike other antidepressants it clears the body relatively quickly.

 

[attention_horror_621]

It's possible. Buspirone significantly increases free serotonin in the brain.

You mean you take 5mg of buspirone?

Overall I would advise not to frequently abuse DXM or use very high doses. Even by itself it can cause psychosis or permanent damage.

But if you do, I would not take buspirone for 1-2 days before DXM. Unlike other antidepressants it clears the body relatively quickly.

woops sorry lol, definitely just 5mg XD, edit made.

thank you!!!

 

[plumbus-nine]

Buspirone is only a partial agonist at 5ht1a, which seems to mean that a SSRI or serotonin releaser will cause more agonism on its own than when combined with buspirone. Why I think to be certain of this is because I was prescribed buspirone while on paroxetine and all it caused were brain zaps, which are usually a marker for serotonergic withdrawal, the opposite of serotonin syndrome. I know in theory can any combination of two or more serotonergic agents cause serotonin syndrome but I'd say risk is exceedingly low for buspirone.

 

[Conky]

Doubt it, serotonin syndrome is actually pretty rare and is usually associated with MAOI use and tricylic antidepressants.

 

[attention_horror_621]

Buspirone is only a partial agonist at 5ht1a, which seems to mean that a SSRI or serotonin releaser will cause more agonism on its own than when combined with buspirone. Why I think to be certain of this is because I was prescribed buspirone while on paroxetine and all it caused were brain zaps, which are usually a marker for serotonergic withdrawal, the opposite of serotonin syndrome. I know in theory can any combination of two or more serotonergic agents cause serotonin syndrome but I'd say risk is exceedingly low for buspirone.

ok thats a relief, thank you!

 

[attention_horror_621]

Doubt it, serotonin syndrome is actually pretty rare and is usually associated with MAOI use and tricylic antidepressants.

awesome, just wanted 2 make sure. thank u!

 

[plumbus-nine]

Doubt it, serotonin syndrome is actually pretty rare and is usually associated with MAOI use and tricylic antidepressants.

Serotonin syndrome can happen from DXM+antidepressant, I think not in deadly strength but last time I took some DXM while being on fluoxetine certainly didn't feel healthy. I'm not sure why, possible that DXM is a slight transporter inverse agonist causing more massive outflux of serotonin than just by a transporter inhibitor like a SSRI.