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bummed about DOF.....but once there was TFMPP

tantric

tantric

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Joined
Jan 2, 2004
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pihkal has DOEF - what happened to DOMF? back in the bad old days, there was TFMPP. what was the point of the tri-fluoromethyl? dare i conjure it? DOMTF? blah, just noodling
 
Trifluoromethyl and methyl are similar in size, but CF3 is more electronegative and hydrophobic, and is resistant to metabolism.

DOTFM exists -- it was made by Nichols and is more potent than DOM.

Shulgin never got around to making DOMF. There were probably other things that he thought were more informative and easier to prepare.
 
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the electron shadow of CF3 has to be very different from C. was DOTFM selective in any interesting ways?
 
It is more potent than DOM. It has apparently only been tested at 5-HT2 subtypes and 5-HT1A, so not much else is known.
 
The -CF3 group is really closer to a bromine or iodine in terms of electronegativity/size.... so on paper 2c-tfm would be like 2c-b or 2c-i.
 
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