I smoked bufotenine one time and it was the only time I ever had a psychedelic body load so horrendously uncomfortable that I was nearly completely convinced that I was about to die from that alone, no psychological component adding to it because there was no headspace other than a mild feeling of dissociation. I like challenging myself with drugs, salvia is one of my favorite things ever, but I don't know if I could bring myself to go through that one again even knowing it should be safe, it was just far too unpleasant to be useful.
It's a shame because the sometimes-repeated claim that it can be even more visual than DMT was true for me, and I think I would have to say that it's the only psychedelic I've taken that visually surpassed DMT specifically using DMT's same sort of style, rather than something more unique and distinct. It obviously has the potential to be incredible in some ways if and when you can manage to enjoy it. Personally though I think I'm probably good sticking to oral 5-MeO-MiPT which does metabolize into 5-HO-MiPT, and honestly does have a pretty bufotenine-like trip for me when I manage to get the psychedelic effects to hit just right and hard and still has significantly less body load, and I still honestly think it might surpass DMT visually in some ways. But it ain't exactly bufotenine still of course, I'd still use that again if I could get around the body load myself.