binding data for phentermine compared to amphetamine and a Frederick if possible

[Morpheus God of morphine]

trying to figure out the binding affinity for Finnegan where I mean Phentermine compared to amphetamine and methamphetamine and ephedrine

 

[allone]

i used to enjoy phentermine A LOT as teen. its really an underrated potent amphetamine that nobody talks about. my favorite parts were when i was getting dick shrinkage while on euphoria watching porn. it was such a huge memorable turn on, i became obsessed with dick shrinkage for some reason haha

 

[Dtuc17]

Yeah I get the same thing now and also just watch p*** on stimulants and nothing else gets done that I intend to do mainly stick with ice these days

 

[izo]

Don’t have binding data at hand right now but phentermine is reported to be a really good substitute for Amphetamine, I wouldn’t be surprised if you couldn’t distinguish both of them in a blind test.

 

[allone]

is it hard to prescribe though? i never heard of anyone using it for weight loss except me 10 years ago. im not even sure if doctors know much about it to prescribe now days anyway

 

[Rectify]

I have overdosed on phentermine and also amphetamine on separate occasions. The phentermine od was even scarier, and the euphoria is not all there even at recommended doses in my experience. Still, with the Adderall shortage, what do you expect?

 

[allone]

how was phentermine od scarier ? im sure any od is scary in general.

 

[Rectify]

Muscles writhing in agony while hearing high pitched screaming sounds with plenty of paranoia.

Generally, overdosing on stimulants is more traumatic because if you od on a sedative, you usually don't remember any of it.

 

[Fertile]

French researchers issued many patents on positional isomers of phentermine:

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ibb.co

It would have got around the UK's PEA law but with 4 enantiomers, either you make a mixture and it's <25% amphetamine in potency OR you work out how to resolve and that isn't as easy as it seems. No patents offer a method and it can be a long process just FINDING an a good method. One would need an acid with 4 enantiomers or perform 2 resolutions.

It just looked like too much work. But they ARE active. I don't think anyone has mentioned the class. I also considered borrowing the cyclobutane ring off stimulants like sibutramine. If you overlay with amphetamine - it's perfect. But once again, the precursors were not commercially available and the synthetic complexity wasn't worth it for a relatively low potency drug.