I've never really managed to hole on anything other than ketamine. I've only holed a handful of times on MXE.
My personal opinion is that you should never look for a replacement, but learn appreciate the different qualities these compounds can offer though.
I spent a long time looking for an MXE replacement, but now I've come to learn each drug has it's merits, and I've learnt to enjoy each experience for what it can offer.
4-meo IM has a wonderful rush, similar to that of ketamine without immobilising oneself.
One thing I've noticed with 4-meo, particularly nasal administration, is if you watch a film whilst on it, and keep your eyes fixated on the screen for a prolonged period of time, object distortion really amazing. My most notable experience with this was where I began to feel almost in a cinema, but then the film broke outside of the realms of the screen.
I'll run through a few quick thoughts
4-meo feels kind of dirty to me, but I kind of like it (only via IM administration though).
I've had no compelling experiences with 3-meo to date, but I think that's down to me not finding my "sweet spot".
MXE has always been incredibly unpredictable for me, but will always be my baby (DOC)
Methoxyketamine (2-meo-ketamine?) was pretty poor if I remember correctly, I don't think it was around for long.
N-ethylketamine I had to take a quite high dose, and didn't really get anywhere worthwile, so I disbanded experiments due to cost effectiveness, but it's a worthwhile avenue if it's available to you.
Esketamine is around from certain places (s-isomer ketamine), and it offers different qualities to ketamine. (I don't know how you could verify, or isolate the s-isomer, but there must be a way).
I came across 3-ho-pcp once, and it was nice, it had an incredible warm glow (opiate activity?) but not so much dissociative. I only got one experience with it, I would give my right arm to explore it further.