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Misc Baclofen

U

UtterlyConfused

Bluelighter
Joined
Jun 27, 2016
Messages
77
As I've mentioned elsewhere, I have Cervical Dystonia. I was having spasms and the such before Baclofen. But since then, early last year, I've felt more anxious, (exacerbation of my Schizotypal/Agoraphobic symptoms), in more pain, more spasms actually and mentally out of it. I'm also, after a year, switching back to Clonzepam from Diazepam which really only does so much in comparison, but that's not what I want to discuss nor is it the appropriate thread for it. So, anyway, here's the thing. I tried last year and again recently this year with an even slower taper. I can't get off of it. Even though it's a low dose. 30mg daily. It's screwed my body and head up even more. But then AGAIN, I can't say that a 100% certainty given the nature of my disorder. Sure as Hell feels like it though. Once I am on my Clonazepam again for a while, and want to come off, what are my options. Is there anything to help ameliorate the symptoms or should I ask to be done under medical supervision? As home taper attempts have been a nightmare.
 
Baclofen has the most severe withdrawal dangers of a drug (the intrathecal Gablofen even comes with a black box warning to avoid cessation abruptly - the only prescription drug to do so:

WARNING: DO NOT DISCONTINUE ABRUPTLY
Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.
Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal. Special attention should be given to patients at apparent risk (e.g., spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen). Consult the technical manual of the implantable infusion system for additional post-implant clinician and patient information [see Warnings and Precautions

Regarding anxiety, Baclofen can indirectly activate certain calcium channel channels (t type) which are excitatory (releasing norepinephrine and glutamate which are enxiogenic - meaning they cause anxiety.)and via presynaptic GABA B receptors inhibits the release of GABA, making less GABA available for your clonazepam to potentiate at the GABA A receptor.


No! taper under medical supervision and it should be done over a couple of months.

The above withdrawal symptoms also occur from withdrawing from oral baclofen
 
I had most of these symptoms all the times I withdrew, and by altered mental status it means delerium, psychosis, hallucinations, delusions...

This is because the GABA B receptor that baclofen works on and activates is a potassium channel called a GIRK ( g coupled inward rectifying potassium) channel that is the same exact GIRK channel that the dopamine D2 channel activates, the dopamine receptor implicated in schizophrenia.
 
Yeah, I've read up on that. They even gave me 4 month taper schedule. Even cutting back 5mg from my 10mg pill caused some fucked up reactions. Here's the thing though that's odd, on the occasion where I've taken an extra, and then it dawns on me that I did, and then continue taking my current dose, it doesn't feel like I took any extra. So, essentially I'm afraid of doing this at home. I'm at the point where I am about 85% sure that it made what I have worse and 15% suspicious that it might just be my Dystonia worsening.
 
Also, about the excitoxicity. Has it gotten any better for you since you've been off of it, if you don't mind me asking?
 
And, so I might have a hard time with my Clonazepam now because of this. Sorry, but now I am freaking out. LOL
 
I doubt it would have much effect. The presynaptic GABA B receptors also have a feedback mechanis by inhibitng almost all types of calcium channels also and the GABA B receptors downregulate quickly.

No, the excitotoxicity and the the psychological symptoms are permanent. it has been 10 months.p-
 
Last edited:
theGirlWithBlueHair said:
I doubt it would have much effect. The presynaptic GABA B receptors also have a feedback mechanis by inhibitng almost all types of calcium channels also and the GABA B receptors downregulate quickly.

No, the excitotoxicity and the the psychological symptoms are permanent. it has been 10 months.
Click to expand...

Just to clarify, is that saying that switching back to the Clonazepam won't help or work? And also, when you say it is permanent, as in terms of anxiety, is it still at the same levels as it was while on it/shortly after coming off of it as it is now for you?
 
No it will have normal efficacy.

No, as in terms of intrusive thoughts and me under the constant idea I'm saying terrible things out loud when I am not, which is something that happened upon abrupt cessation - which is a delusion.
 
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