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Ayahuasca and medication interaction: gabapentin 300mg and trazodon 50mg

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Pars101

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Feb 9, 2011
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Hi, my cousin has quit opiates for around 2 weeks. His doctor gave him Gabapentin 300mg and Trazodone 50mg (he took these pills for about a week only). As he stopped taking them 6 days ago because he wanted to do ayahuasca tonight (and he was told those prescription drugs are dangerous with ayahuasca). I just want to make sure that taking ayahuasca tonight would 100% be safe for him? as I mentioned he has told me that he stopped taking Gabapentin and Trazodone around 6 days ago.

His ayahuasca brew is made from 6 grams of mimosa hostilis and 3/4 grams of syrian rue.

Also, 3 nights ago he took low doses of diazapam, xanax and clonazepam. His stuck to his ayahuasca diet in this time.


Thank you for your help!!! :)
 
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MAOIs combined with Serotonin update inhibitors like Trazadon can lead to (posybly lethal) Serotonin Syndrom. Kick it of and rely on the Benzos for sleeping.
 
ungelesene_bettlek said:
MAOIs combined with Serotonin update inhibitors like Trazadon can lead to (posybly lethal) Serotonin Syndrom. Kick it of and rely on the Benzos for sleeping.
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He has stopped taking Trazodone for around 6 days, is that a long enough gap? so can he take ayahuasca because he has not taken Trazadon for 6 days now.
 
Pars101 said:
He has stopped taking Trazodone for around 6 days, is that a long enough gap? so can he take ayahuasca because he has not taken Trazadon for 6 days now.
Click to expand...
If he experiences no "brain zaps" or other difficulties, he'll be fine, I guess, but don't quote me on that, I'm no medical doctor or pharmacist. Probably his effects will be a bit dimished, because of 5HT2A-Receptor-Downregulation, because of Trazdone being an SRI (besides other things). Also the benzos will dull his ayahuasca experience to some degree to, so better also reduce this to the bare minimum.
 
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yeah Trazodone is definately a SRI and thus not to be combined with MAOI. it is also a 5HT-2A antagonist which could mean upregulation of said receptors which could even intensify the brew. I'd wait for a longer time before consuming ayahuasca.

btw, ungelesene_bettlektüre, I remember you from m.at (long time ago). what's up? :)
 
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