TECHNICALLY, cipro effects the CNS, so if your epileptic, I would consider changing antibiotics, as it uncompetitively inhibits GABA-A, abd can reduce the effects of Benzodiazepines
It’s surprising, well at least to me, that thus side effect isn’t more well known
Many, if not most NSAIDS also have been demonstrated more than once to have a, IIRC, a dose dependant, reduction of Benzodiazepine effects, it’s probably just mild enough the average person wouldn’t notice unless they are overtaking their NSAID(s)
I still think caution should be exercised, and the CNS effects of the quinolone (*) antibiotics and cipro in particular, are more well documented, and if your epileptics, proceed with some caution, maybe find if half the dose has any descirnable effects