sekio
Bluelight Crew
- Joined
- Sep 14, 2009
- Messages
- 21,994
Well, let's see.
W: Zuclopenthixol is a D1 and D2 antagonist, α1-adrenergic and 5-HT2 antagonist.
That crosses out all the classical psychedelics in one swoop. D1, D2, antagonism will reduce the euphoric/rewarding effects of, erm, dopaminergic stimulants (meth, cocaine, amphetmaine, methylphenidate, MDPV, the like), but will not totally block the focus-enhancing stimulatory effects that norepinephrine is more responsible for. So stimulants are a "maybe". MDMA is included, though it may not be as "trippy" it could work.
I am told that DMT is not entirely blocked by 5-HT2a antagonism, it could be interesting to try.
Dissociative drugs like PCP, ketamine should work, being NMDA antagonists. DXM may work too, it is also a serotonin/norepinephrine reuptake and sigma agonist. Nitrous oxide should work.
Amanita muscaria, and its active component muscimol, would be active. It acts at GABA-A.
Salvia divinorum, kappa opioid agonist, powerful hallucinogen, should work.
GHB and its friends will probably work (GABA-B and GHB receptor)
Caffeine, alcohol, amyl nitrite, all OK.
Cannabis and other cannabinoids should work.
Are there any more fun drugs I missed?
W: Zuclopenthixol is a D1 and D2 antagonist, α1-adrenergic and 5-HT2 antagonist.
That crosses out all the classical psychedelics in one swoop. D1, D2, antagonism will reduce the euphoric/rewarding effects of, erm, dopaminergic stimulants (meth, cocaine, amphetmaine, methylphenidate, MDPV, the like), but will not totally block the focus-enhancing stimulatory effects that norepinephrine is more responsible for. So stimulants are a "maybe". MDMA is included, though it may not be as "trippy" it could work.
I am told that DMT is not entirely blocked by 5-HT2a antagonism, it could be interesting to try.
Dissociative drugs like PCP, ketamine should work, being NMDA antagonists. DXM may work too, it is also a serotonin/norepinephrine reuptake and sigma agonist. Nitrous oxide should work.
Amanita muscaria, and its active component muscimol, would be active. It acts at GABA-A.
Salvia divinorum, kappa opioid agonist, powerful hallucinogen, should work.
GHB and its friends will probably work (GABA-B and GHB receptor)
Caffeine, alcohol, amyl nitrite, all OK.
Cannabis and other cannabinoids should work.
Are there any more fun drugs I missed?