Fornax55
Bluelighter
- Joined
- Jun 17, 2010
- Messages
- 466
Hey, I was just poking around and I read this study that was investigating the effects of opioids on blood plasma concentrations of malondialdehyde(MDA).
They found that MDA plasma levels increased during morphine administration and then increased significantly after naloxone injections during withdrawal. Rats treated with antioxidants (alpha-lipoic acid) showed decreases in MDA plasma levels and 'abstinence signs,' the ALA would scavenge peroxides and interfere with other metabolites involved in w/d.
I couldn't find a clear answer about what MDA does if there's too much present in blood plasma, hence the post. This seems to suggest that a notable attenuation of withdrawal symptoms can be garnered from using ALA or other strong antioxidants. Anyone have experience with this, or am I missing something?
https://www.ncbi.nlm.nih.gov/pubmed/18705754
They found that MDA plasma levels increased during morphine administration and then increased significantly after naloxone injections during withdrawal. Rats treated with antioxidants (alpha-lipoic acid) showed decreases in MDA plasma levels and 'abstinence signs,' the ALA would scavenge peroxides and interfere with other metabolites involved in w/d.
I couldn't find a clear answer about what MDA does if there's too much present in blood plasma, hence the post. This seems to suggest that a notable attenuation of withdrawal symptoms can be garnered from using ALA or other strong antioxidants. Anyone have experience with this, or am I missing something?
https://www.ncbi.nlm.nih.gov/pubmed/18705754