Maybe look beyond peptides into what we believe promotes longevity..
Optimal mitochondrial function, reducing mTOR, and IGF-1, telomere lengthening.. etc
This is interdasting to me as, mitochondial function as I understand it, is responsible for ATP production which powers ion pumps, responsible for nerve action potential propagation.
The historical thinking is, "
cellular function slows with age", that is to say, excitatory cellular function (nerve cells), which would correlate with reduced mitochondrial function.
Hormone regulation seems to be a secondary affect of CNS nerve function via the HPA axis thus, my general thinking is, maintenance of good/optimal nervous system function is really kind of the overarching parameter of well being, but in this instance, anti-aging and appearance maintenance.
....
I have an additional contention that inflammatory conditions are somewhat consistent with compromised or insufficient neural firing - inflammatory mediators become active with insufficiently active nerves?
I rationalize that my way of certain endocrinologist treatments aimed treating the "downstream" affects of a compromised nervous system by way of supplementation targeting inflammatory mediators, and in some case, hormone replacement therapy.
A conversation with Mark L. Gordon, M.D.
www.psychologytoday.com
This dude "Mark Gordon" seems to pioneer that, and has written extensively for "Life Extension" magazine as to how his propositions are effective in that capacity (re growth hormone, testosterone supplementation etc).