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Anti-aging drugs discovered
By Bradley J. Fikes
MARCH 9, 2015
A new class of anti-aging drugs has been identified in a study by a team from The Scripps Research Institute and the Mayo Clinic. In mice, the drugs reduce frailty, improve heart function and extends a healthy lifespan.
The drugs, which the researchers have dubbed "senolytics," work by causing senescent cells to die. These cells secrete harmful substances that damage other cells, including stem cells, said study contributor Laura J. Niedernhofer, a Scripps Research scientist in Jupiter, Florida.
Since these substances are already approved for human use, researchers say clinical trials should be relatively easy to arrange in a short time. They are the cancer drug dasatinib, sold under the brand name Sprycel; and quercetin, a nutritional supplement with antihistamine and anti-inflammatory properties. And even stronger drugs may be discovered, now that researchers know what to look for.
"If senolytic agents can indeed be brought into clinical application, they could be transformative," the study stated. "With intermittent short treatments, it may eventually become feasible to delay, prevent, alleviate, or even reverse multiple chronic diseases and disabilities as a group, instead of one at a time."
continued here http://www.utsandiego.com/news/2015/mar/09/aging-scripps-mayo-senolytics/
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The Achilles’ Heel of Senescent Cells: From Transcriptome to Senolytic Drugs
By Bradley J. Fikes
MARCH 9, 2015
A new class of anti-aging drugs has been identified in a study by a team from The Scripps Research Institute and the Mayo Clinic. In mice, the drugs reduce frailty, improve heart function and extends a healthy lifespan.
The drugs, which the researchers have dubbed "senolytics," work by causing senescent cells to die. These cells secrete harmful substances that damage other cells, including stem cells, said study contributor Laura J. Niedernhofer, a Scripps Research scientist in Jupiter, Florida.
Since these substances are already approved for human use, researchers say clinical trials should be relatively easy to arrange in a short time. They are the cancer drug dasatinib, sold under the brand name Sprycel; and quercetin, a nutritional supplement with antihistamine and anti-inflammatory properties. And even stronger drugs may be discovered, now that researchers know what to look for.
"If senolytic agents can indeed be brought into clinical application, they could be transformative," the study stated. "With intermittent short treatments, it may eventually become feasible to delay, prevent, alleviate, or even reverse multiple chronic diseases and disabilities as a group, instead of one at a time."
continued here http://www.utsandiego.com/news/2015/mar/09/aging-scripps-mayo-senolytics/
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The Achilles’ Heel of Senescent Cells: From Transcriptome to Senolytic Drugs
