Zalo
Bluelighter
- Joined
- Oct 11, 2012
- Messages
- 410
Hey BlueLight,
I've read that you can sensitize yourself to amphetamines 'permanently' by taking low doses everyday for a week. I'm not sure what the mechanism is behind this, but I'd imagine it to be attributed to increased synaptic connections of dopamine/norepinephrine neurons. Since MDMA affects dopamine/norepinephrine transmission, which is part of why its stimulatory, I'm wondering if those who've sensitized themselves with amphetamines have more pronounced stimulatory effects from MDMA.
A friend of mine with ADHD has been taking low dose amphetamines for most of his life and claimed that he felt like he was going to "explode" with energy the last time he was on MDMA (which was his second time with a slightly higher dose [130mg] from his first time [120mg]). He's 100kg. I'm not sure if he's naturally sensitive to stimulants or the sensitivity was from low dose amphetamine use, so now I'm curious.
Thank you.
I've read that you can sensitize yourself to amphetamines 'permanently' by taking low doses everyday for a week. I'm not sure what the mechanism is behind this, but I'd imagine it to be attributed to increased synaptic connections of dopamine/norepinephrine neurons. Since MDMA affects dopamine/norepinephrine transmission, which is part of why its stimulatory, I'm wondering if those who've sensitized themselves with amphetamines have more pronounced stimulatory effects from MDMA.
A friend of mine with ADHD has been taking low dose amphetamines for most of his life and claimed that he felt like he was going to "explode" with energy the last time he was on MDMA (which was his second time with a slightly higher dose [130mg] from his first time [120mg]). He's 100kg. I'm not sure if he's naturally sensitive to stimulants or the sensitivity was from low dose amphetamine use, so now I'm curious.
Thank you.