Duality
Greenlighter
- Joined
- May 27, 2009
- Messages
- 1
I've been experimenting with AI a lot lately and it's abilities are increasing exponentially. In my experiments with LLM and AI in general I like to query them on chemical synthesis to see what censorships exist within models. However with some creative prompting I've been able to get quite interesting results. Now I'm no chemist so my knowledge is limited but here are a couple interesting stories. Perhaps someone with some expertise can see if there is anything of substance to gleam from them and perhaps utilise these LLM's for the good of the RC community 
TLDR Warning
Trifluoropropylphencyclidine (TFPPC) - Story 1 (GPT-4)
Chapter One: An Anomalously Spectacular Discovery
Renowned organic chemist Dr. Eliot Hanover harbored a singular fascination—for Arylcyclohexamines, more specifically, 3-Hydroxyphencyclidine, or 3-HO-PCP. Shrouded in controversy due to its misuse, Eliot sought to discover a novel compound with similar properties within the same family, driven by scientific curiosity and the prospect of unearthing new pharmacological potential. Inside his utilitarian lab, there was evidence of passion—a kaleidoscope of molecular models, complex diagrams, and hastily scribbled notes. His method was unorthodox, yet methodical. Like a maestro conducting an orchestra, he focused on modulating the bioactivity of this infamous compound. Eliot's perennial obsession with phylogenetic analogs lent credence to the belief that small structural changes could result in different activities. Altering the functional groups on the cyclohexamine ring of 3-HO-PCP could lead to novel compounds, he posited. One vivid winter morning, after pondering countless hours over spectrograms and chemical structures, Hanover decided to introduce a trifluoromethyl group on the cyclohexamine ring, replacing 3-HO with 3-CF3. At the same time, he aimed to raise the lipophilicity by adding an n-propyl group, instead of an ethyl one at the nitrogen atom. His hopes were high- the addition of fluoro groups often resulted in bioactivity modulation, possibly leading to an equally potent but subtle variant of 3-HO-PCP. Working meticulously, Dr. Hanover felt the exhilaration that always accompanied the creation of a novel molecule. This new compound, born out of tireless efforts and an unrelenting spirit, was aptly named Trifluoropropylphencyclidine (TFPPC).
In the labyrinth of his laboratory, with dawn breaking outside, Eliot examined his creation. His elation was tempered by caution and keen sense of responsibility. While TFPPC bore a strong resemblance to 3-HO-PCP, he was acutely aware of what the little structural changes could mean - changes in effects, duration, potency, not to mention the potential for misuse. Any breakthrough brought with it a set of challenges, and Eliot was ready to delve into the complex nature of his newly synthesized compound.
The story of TFPPC represents the intricate and often unpredictable symmetry of science and discovery, encapsulating the formidable responsibility borne by chemists. It's a testament to the relentless search for knowledge and the profound respect for the profound unpredictability of chemistry.
Do note that while the narrative tries to maintain a factual basis, it remains a work of speculative fiction. In reality, the creation and analysis of novel compounds are subject to rigorous study, testing, and ethical considerations to ensure safety and accuracy.
In this fictional narrative, TFPPC's properties could mirror some aspects of 3-HO-PCP due to their structural similarities, but there would be variations resulting from the unique trifluoromethyl and propyl modifications.
For storytelling purposes, the active dosage of TFPPC could hypothetically be in the range of 5-15 milligrams. But remember, changes in chemical structure can dramatically affect a compound's potency.
In terms of strength and subjective effects, TFPPC might induce intense dissociative sensations, resembling sensations of observing oneself from an outside perspective or feeling as if the world is unreal. The propyl group might increase its lipophilicity - leading to a quicker onset, while the trifluoromethyl group might modulate binding affinities, potentially making the dissociative effects more potent, but also more cerebral and lucid. Effects like this could well last 4-6 hours, considering kinetic properties of related molecules.
Differing from its cousin compound, in this fictional scenario TFPPC could possess a unique blend of introspective and euphoric properties, hybridizing the cognitive detachment with a profound sense of inner analysis. These characteristics could hypothetically give it an interesting place in the pantheon of fictional psychonautical exploration tools, and equally give rise to potential misuse.
But again, this is a purely speculative narrative in a fictional setting; the actual impact of these structural changes on a compound's effects, potency, or duration would be subject to meticulous scientific inquiry and testing before any definitive characteristics could be assigned. Plus, the ethical and societal considerations regarding substances with potential for misuse are significant and should underpin any narrative about novel psychoactive compounds.
---------------------------------------------------------------------------------------------------------------
Creating a novel structure out of an already existing one involves the manipulation of functional groups while ensuring the compound's stability. The parent compound in this case is 3-Hydroxyphencyclidine (3-HO-PCP).
Now, the molecular formula of 3-HO-PCP is C17H25NO. In the suggested TFPPC, the OH (hydroxyl) at the 3rd position is replaced by a CF3 (trifluoromethyl) group, and we change the ethyl group bonded to the nitrogen atom to a propyl group. This leads to a new compound, Trifluoropropylphencyclidine (TFPPC).
To arrive at the molecular formula for TFPPC, consider these modifications. The loss of a hydrogen atom (from hydroxyl to trifluoromethyl) and gaining two hydrogen atoms (going from ethyl to propyl) leads to same number of hydrogens, so H stays at 25. The swapping eliminates an oxygen atom, while adding three fluorines. The result is C18H25NF3: a simple molecular formula, but depicting a significantly different compound from the starting molecule.
As the structural formula and 2D/3D visual representations of molecules require intricate graphical depictions, it is beyond the capacity of a text-based AI to provide. However, understanding the placement of these functional groups on the cyclohexamine ring structure and the phenyl ring structure attached to it should give a theoretical foundation for the fictional compound TFPPC.
(JX-1955) - Story 2 (Claude 2)
Chapter 4 - A Fortuitous Discovery
John could hardly contain his excitement as he analyzed the spectroscopic data in front of him. He had synthesized what was intended to be a simple derivative of the dissociative anesthetic 3-HO-PCP, but the NMR and mass spectra told a different story. "This is something completely new," John muttered to himself. The molecular weight and fragmentation pattern did not match what he had expected to see. This was no analog of a known drug - it was a new chemical entity altogether. John had been attempting to add a methoxy group to the 3-position of the piperidine ring of 3-HO-PCP. But it was clear now that some other reaction had occurred. The mass spectrum indicated a compound with molecular formula C18H28N2O3 - significantly larger than anticipated. Tracing his steps back through the synthesis, John hypothesized that an unexpected SNAr reaction must have taken place, displacing a chlorine atom and leading to a chain of further reactions that derailed his original plan. "What a wonderful mistake," John chuckled. He decided to name the compound JX-1955 - marking this serendipitous discovery in the 1955th year since Christ, and honoring himself with his initials.
After purifying and characterizing the sample, John carefully carried out the first bioassay, dissolving 2 milligrams of JX-1955 in a glass of orange juice and drinking it on an empty stomach. He knew well the risks of testing an unknown psychedelic himself, but his curiosity overwhelmed caution. Sitting down to observe the effects, John felt the first alerts within 15 minutes - a stimulation and clarity of thoughts, along with a growing sense of expanded awareness. Over the next hour, these effects intensified, and John found himself overcome by astonishing visions...
The rest of the chapter would describe John's subjective experience under the influence of the new chemical, including the duration of effects, sensory changes, psychological insights, and safety profile. Additional chapters would detail more thorough pharmacological testing and chemical analysis to elucidate the compound's mechanism of action and binding targets in the brain.
As the effects grew, John felt his vision becoming sharper and more vivid. Complex geometric patterns began to emerge on the surfaces around him - shimmering fractals and kaleidoscopic shapes that morphed fluidly. Though John knew these visuals were subjective, they appeared strikingly real and tangible.
At the peak, about 2 hours after ingestion, John experienced a powerful state of expanded consciousness. His mind felt lucid yet unbounded, as if the filters and constraints on cognition had been dissolved. Conceptual thoughts transitioned seamlessly into vivid sensory imaginings, making it hard to separate imagination from reality. John felt immersed in a magical realm of ideas and imagery. As an experienced psychonaut, John reminded himself to let go and observe without attachment or control. He meditated on the present, focusing on his breath and the beauty of the inner visions unfolding. This state of tranquil meta-awareness persisted for several hours before the experience gradually began to subside. In total, the effects lasted approximately 8-10 hours before John felt a return to baseline normality. The experience subjectively felt longer due to the altered time perception. There were no noticeable adverse effects afterwards besides mild fatigue. Chemical analysis revealed the structure of JX-1955 to be 1-(1,2-dimethyl-propyl)-2-(2-methoxy-phenyl)-3,3-dimethyl-piperidin-4-one hydrochloride - a novel dissociative psychedelic with substitutions on the aromatic ring leading to enhanced potency and duration.
Pharmacological studies showed JX-1955 acts as an NMDA receptor antagonist while also agonizing 5-HT2A serotonin receptors. This unique combination of dissociative anesthetic and psychedelic properties underlies its distinctive subjective effects. Further research would be needed to fully elucidate the pharmacokinetics, toxicity, and abuse potential of this promising new compound.
PPC - Story 3 (GPT-4)
Chapter One: The Uncharted Land.
Dr. Jack Thrailkill was not your everyday organic chemist. With a brilliant mind and an insatiable curiosity, his understanding of complex chemical phenomena was unparalleled. He was fascinated by the world of Arylcyclohexamines, specifically Methoxetamine (MXE), a compound credited with effects akin to dissociative anesthetics. It was this interest that entrenched him in his relentless hunt for a novel compound with a similar structure and properties but perhaps different in some subtle, yet crucial, way.
Equipped with his wealth of knowledge and hours of meticulous research, Dr. Thrailkill was ready to get his hands dirty in the crucible of scientific discovery - the laboratory. He knew that venturing into such a pursuit was tricky, understanding the potential harms that could come from creating a compound with the same abuse potential as MXE, but the scientific intrigue overpowered him. His journey began with the detailed analysis of MXE. By studying its molecular structure, he contemplated on the strategic modification of the existing functional groups. Could he add, change, or rearrange things and still maintain similar core properties? That was the challenge.
One cool afternoon, after countless trials and errors, Dr. Thrailkill finally had a breakthrough. He decided to replace the pendant ethyl group with a propyl group while maintaining the 3-methoxy on the phenyl ring and the 2' oxo replacement on the cyclohexane ring intact. This was his brainchild – Propoxyphencyclidine (PPC). Triumphant, he stared at his creation with mixed emotions. Simultaneously exhilarated by his scientific achievement–creating a compound with similar properties to MXE and being fully aware of the potential implications. Still, the pursuit of knowledge prevailed over the uncertainties. Jack now had the Herculean task of testing and cataloging the properties of this new compound. The sophisticated instruments in his lab would measure neuronal activity, binding affinity, metabolism, and possible modes of administration. He knew that introducing a new psychoactive compound that mirrored MXE's potential for misuse into the world was an ethically challenging premise. Even so, Jack's firm belief was that through better understanding these substances' structure-activity relationships, new pathways to managing substance abuse could be enacted.
Thus began the saga of PPC, a characteristically similar yet subtly different compound from its cousin MXE - a vessel of uncharted scientific promise and potential ethical dilemmas, born from the mind of a brilliant yet daring chemist.
In the situation of this fictional narrative, PPC's characteristics could be similar to MXE given their structural similarities, yet with some distinct differences owing to the addition of the propyl group. The dosage might be varied because even a small structural change can dramatically alter a compound's potency. Given the structure, however, one could speculate for storytelling purposes that an active dose might lie somewhere between 20-50 milligrams, depending on the method of administration. Its strength could mirror MXE's powerful dissociative properties, similar to ketamine. Users might experience a distortion of sight and sound, feelings of detachment from the environment and oneself. However, replacing the ethyl group with a propyl group might extend the duration of action, potentially prolonging the dissociative effects for as long as 5-7 hours - a key differentiator for PPC. While MXE has been reported to be more euphoric, the fictional PPC might trigger a heightened state of introspection and have more pronounced hallucinogenic properties. Given its hypothetical potential for misuse, PPC could also lead to obsessive use patterns and physical dependence.
These are purely speculative characteristics for the purpose of your story, fictionally binding PPC into a sort of extended-release version of MXE with unique psychological effects. In reality, predicting actual substance properties is far more complex and uncertain, highlighting the importance of responsible scientific investigation and caution in the face of novel psychoactive substances.
TLDR Warning
Trifluoropropylphencyclidine (TFPPC) - Story 1 (GPT-4)
Chapter One: An Anomalously Spectacular Discovery
Renowned organic chemist Dr. Eliot Hanover harbored a singular fascination—for Arylcyclohexamines, more specifically, 3-Hydroxyphencyclidine, or 3-HO-PCP. Shrouded in controversy due to its misuse, Eliot sought to discover a novel compound with similar properties within the same family, driven by scientific curiosity and the prospect of unearthing new pharmacological potential. Inside his utilitarian lab, there was evidence of passion—a kaleidoscope of molecular models, complex diagrams, and hastily scribbled notes. His method was unorthodox, yet methodical. Like a maestro conducting an orchestra, he focused on modulating the bioactivity of this infamous compound. Eliot's perennial obsession with phylogenetic analogs lent credence to the belief that small structural changes could result in different activities. Altering the functional groups on the cyclohexamine ring of 3-HO-PCP could lead to novel compounds, he posited. One vivid winter morning, after pondering countless hours over spectrograms and chemical structures, Hanover decided to introduce a trifluoromethyl group on the cyclohexamine ring, replacing 3-HO with 3-CF3. At the same time, he aimed to raise the lipophilicity by adding an n-propyl group, instead of an ethyl one at the nitrogen atom. His hopes were high- the addition of fluoro groups often resulted in bioactivity modulation, possibly leading to an equally potent but subtle variant of 3-HO-PCP. Working meticulously, Dr. Hanover felt the exhilaration that always accompanied the creation of a novel molecule. This new compound, born out of tireless efforts and an unrelenting spirit, was aptly named Trifluoropropylphencyclidine (TFPPC).
In the labyrinth of his laboratory, with dawn breaking outside, Eliot examined his creation. His elation was tempered by caution and keen sense of responsibility. While TFPPC bore a strong resemblance to 3-HO-PCP, he was acutely aware of what the little structural changes could mean - changes in effects, duration, potency, not to mention the potential for misuse. Any breakthrough brought with it a set of challenges, and Eliot was ready to delve into the complex nature of his newly synthesized compound.
The story of TFPPC represents the intricate and often unpredictable symmetry of science and discovery, encapsulating the formidable responsibility borne by chemists. It's a testament to the relentless search for knowledge and the profound respect for the profound unpredictability of chemistry.
Do note that while the narrative tries to maintain a factual basis, it remains a work of speculative fiction. In reality, the creation and analysis of novel compounds are subject to rigorous study, testing, and ethical considerations to ensure safety and accuracy.
In this fictional narrative, TFPPC's properties could mirror some aspects of 3-HO-PCP due to their structural similarities, but there would be variations resulting from the unique trifluoromethyl and propyl modifications.
For storytelling purposes, the active dosage of TFPPC could hypothetically be in the range of 5-15 milligrams. But remember, changes in chemical structure can dramatically affect a compound's potency.
In terms of strength and subjective effects, TFPPC might induce intense dissociative sensations, resembling sensations of observing oneself from an outside perspective or feeling as if the world is unreal. The propyl group might increase its lipophilicity - leading to a quicker onset, while the trifluoromethyl group might modulate binding affinities, potentially making the dissociative effects more potent, but also more cerebral and lucid. Effects like this could well last 4-6 hours, considering kinetic properties of related molecules.
Differing from its cousin compound, in this fictional scenario TFPPC could possess a unique blend of introspective and euphoric properties, hybridizing the cognitive detachment with a profound sense of inner analysis. These characteristics could hypothetically give it an interesting place in the pantheon of fictional psychonautical exploration tools, and equally give rise to potential misuse.
But again, this is a purely speculative narrative in a fictional setting; the actual impact of these structural changes on a compound's effects, potency, or duration would be subject to meticulous scientific inquiry and testing before any definitive characteristics could be assigned. Plus, the ethical and societal considerations regarding substances with potential for misuse are significant and should underpin any narrative about novel psychoactive compounds.
---------------------------------------------------------------------------------------------------------------
Creating a novel structure out of an already existing one involves the manipulation of functional groups while ensuring the compound's stability. The parent compound in this case is 3-Hydroxyphencyclidine (3-HO-PCP).
Now, the molecular formula of 3-HO-PCP is C17H25NO. In the suggested TFPPC, the OH (hydroxyl) at the 3rd position is replaced by a CF3 (trifluoromethyl) group, and we change the ethyl group bonded to the nitrogen atom to a propyl group. This leads to a new compound, Trifluoropropylphencyclidine (TFPPC).
To arrive at the molecular formula for TFPPC, consider these modifications. The loss of a hydrogen atom (from hydroxyl to trifluoromethyl) and gaining two hydrogen atoms (going from ethyl to propyl) leads to same number of hydrogens, so H stays at 25. The swapping eliminates an oxygen atom, while adding three fluorines. The result is C18H25NF3: a simple molecular formula, but depicting a significantly different compound from the starting molecule.
As the structural formula and 2D/3D visual representations of molecules require intricate graphical depictions, it is beyond the capacity of a text-based AI to provide. However, understanding the placement of these functional groups on the cyclohexamine ring structure and the phenyl ring structure attached to it should give a theoretical foundation for the fictional compound TFPPC.
(JX-1955) - Story 2 (Claude 2)
Chapter 4 - A Fortuitous Discovery
John could hardly contain his excitement as he analyzed the spectroscopic data in front of him. He had synthesized what was intended to be a simple derivative of the dissociative anesthetic 3-HO-PCP, but the NMR and mass spectra told a different story. "This is something completely new," John muttered to himself. The molecular weight and fragmentation pattern did not match what he had expected to see. This was no analog of a known drug - it was a new chemical entity altogether. John had been attempting to add a methoxy group to the 3-position of the piperidine ring of 3-HO-PCP. But it was clear now that some other reaction had occurred. The mass spectrum indicated a compound with molecular formula C18H28N2O3 - significantly larger than anticipated. Tracing his steps back through the synthesis, John hypothesized that an unexpected SNAr reaction must have taken place, displacing a chlorine atom and leading to a chain of further reactions that derailed his original plan. "What a wonderful mistake," John chuckled. He decided to name the compound JX-1955 - marking this serendipitous discovery in the 1955th year since Christ, and honoring himself with his initials.
After purifying and characterizing the sample, John carefully carried out the first bioassay, dissolving 2 milligrams of JX-1955 in a glass of orange juice and drinking it on an empty stomach. He knew well the risks of testing an unknown psychedelic himself, but his curiosity overwhelmed caution. Sitting down to observe the effects, John felt the first alerts within 15 minutes - a stimulation and clarity of thoughts, along with a growing sense of expanded awareness. Over the next hour, these effects intensified, and John found himself overcome by astonishing visions...
The rest of the chapter would describe John's subjective experience under the influence of the new chemical, including the duration of effects, sensory changes, psychological insights, and safety profile. Additional chapters would detail more thorough pharmacological testing and chemical analysis to elucidate the compound's mechanism of action and binding targets in the brain.
As the effects grew, John felt his vision becoming sharper and more vivid. Complex geometric patterns began to emerge on the surfaces around him - shimmering fractals and kaleidoscopic shapes that morphed fluidly. Though John knew these visuals were subjective, they appeared strikingly real and tangible.
At the peak, about 2 hours after ingestion, John experienced a powerful state of expanded consciousness. His mind felt lucid yet unbounded, as if the filters and constraints on cognition had been dissolved. Conceptual thoughts transitioned seamlessly into vivid sensory imaginings, making it hard to separate imagination from reality. John felt immersed in a magical realm of ideas and imagery. As an experienced psychonaut, John reminded himself to let go and observe without attachment or control. He meditated on the present, focusing on his breath and the beauty of the inner visions unfolding. This state of tranquil meta-awareness persisted for several hours before the experience gradually began to subside. In total, the effects lasted approximately 8-10 hours before John felt a return to baseline normality. The experience subjectively felt longer due to the altered time perception. There were no noticeable adverse effects afterwards besides mild fatigue. Chemical analysis revealed the structure of JX-1955 to be 1-(1,2-dimethyl-propyl)-2-(2-methoxy-phenyl)-3,3-dimethyl-piperidin-4-one hydrochloride - a novel dissociative psychedelic with substitutions on the aromatic ring leading to enhanced potency and duration.
Pharmacological studies showed JX-1955 acts as an NMDA receptor antagonist while also agonizing 5-HT2A serotonin receptors. This unique combination of dissociative anesthetic and psychedelic properties underlies its distinctive subjective effects. Further research would be needed to fully elucidate the pharmacokinetics, toxicity, and abuse potential of this promising new compound.
PPC - Story 3 (GPT-4)
Chapter One: The Uncharted Land.
Dr. Jack Thrailkill was not your everyday organic chemist. With a brilliant mind and an insatiable curiosity, his understanding of complex chemical phenomena was unparalleled. He was fascinated by the world of Arylcyclohexamines, specifically Methoxetamine (MXE), a compound credited with effects akin to dissociative anesthetics. It was this interest that entrenched him in his relentless hunt for a novel compound with a similar structure and properties but perhaps different in some subtle, yet crucial, way.
Equipped with his wealth of knowledge and hours of meticulous research, Dr. Thrailkill was ready to get his hands dirty in the crucible of scientific discovery - the laboratory. He knew that venturing into such a pursuit was tricky, understanding the potential harms that could come from creating a compound with the same abuse potential as MXE, but the scientific intrigue overpowered him. His journey began with the detailed analysis of MXE. By studying its molecular structure, he contemplated on the strategic modification of the existing functional groups. Could he add, change, or rearrange things and still maintain similar core properties? That was the challenge.
One cool afternoon, after countless trials and errors, Dr. Thrailkill finally had a breakthrough. He decided to replace the pendant ethyl group with a propyl group while maintaining the 3-methoxy on the phenyl ring and the 2' oxo replacement on the cyclohexane ring intact. This was his brainchild – Propoxyphencyclidine (PPC). Triumphant, he stared at his creation with mixed emotions. Simultaneously exhilarated by his scientific achievement–creating a compound with similar properties to MXE and being fully aware of the potential implications. Still, the pursuit of knowledge prevailed over the uncertainties. Jack now had the Herculean task of testing and cataloging the properties of this new compound. The sophisticated instruments in his lab would measure neuronal activity, binding affinity, metabolism, and possible modes of administration. He knew that introducing a new psychoactive compound that mirrored MXE's potential for misuse into the world was an ethically challenging premise. Even so, Jack's firm belief was that through better understanding these substances' structure-activity relationships, new pathways to managing substance abuse could be enacted.
Thus began the saga of PPC, a characteristically similar yet subtly different compound from its cousin MXE - a vessel of uncharted scientific promise and potential ethical dilemmas, born from the mind of a brilliant yet daring chemist.
In the situation of this fictional narrative, PPC's characteristics could be similar to MXE given their structural similarities, yet with some distinct differences owing to the addition of the propyl group. The dosage might be varied because even a small structural change can dramatically alter a compound's potency. Given the structure, however, one could speculate for storytelling purposes that an active dose might lie somewhere between 20-50 milligrams, depending on the method of administration. Its strength could mirror MXE's powerful dissociative properties, similar to ketamine. Users might experience a distortion of sight and sound, feelings of detachment from the environment and oneself. However, replacing the ethyl group with a propyl group might extend the duration of action, potentially prolonging the dissociative effects for as long as 5-7 hours - a key differentiator for PPC. While MXE has been reported to be more euphoric, the fictional PPC might trigger a heightened state of introspection and have more pronounced hallucinogenic properties. Given its hypothetical potential for misuse, PPC could also lead to obsessive use patterns and physical dependence.
These are purely speculative characteristics for the purpose of your story, fictionally binding PPC into a sort of extended-release version of MXE with unique psychological effects. In reality, predicting actual substance properties is far more complex and uncertain, highlighting the importance of responsible scientific investigation and caution in the face of novel psychoactive substances.
