Agomelatine Worsens Parkison's Disease.

[Bravoncius Roxford]

Agomelatine is a melatonergic antidepressant manufactured by the French pharmceutical company, Servier. It is also a weak antagonist of certain serotonin receptors. A new study indicates that agomelatine accelerates the progression of Parkinson's and worsens symptoms of the disease, like dyskinesia in laboratory rats. Autopsies of the brains of the rats show markers of increased inflammation, oxidative stress and loss of cells in the striatum. Here is the study: https://www.ncbi.nlm.nih.gov/pubmed/30716425 This merits consideration for those thinking about using AM as na antidepressant, especially for those with a tendency for Parkinson's.

 

[S.J.B.]

Let's be clear that these rats do not have Parkinson's disease, which is a human disease, but a model thereof. The researchers state in the abstract: "agomelatine exacerbates rotenone-induced toxicity which mimics Parkinson's disease pathology."

 

[Skorpio]

Well shit. I guess I have to stop taking rotenone.

 

[Bravoncius Roxford]

Well shit. I guess I have to stop taking rotenone.

The rats given only rotenone displayed significantly lower levels of damage to the striatum than the rats that were also given agomelatine. This would indicate AM is toxic on it's own.