Personally, I don't trip if I'm immobilized. I'm waiting anxiously to try the sample of MEM I managed to get, but I'm still recovering from 2 recent surgeries so it's a no go atm. I'm someone who prefers trip out in the back country, not indoors. Not everyone prefers to trip outdoors, so that may not apply to you.
Opioids don't tend to heavily interfere with psychedelics, just mellow it out a bit, esp with tryptamines. YMMV of course