2C-X and receptor downregulation

[Xorkoth]

Yeah, the last time I took 2C-E, it was a few years ago right after I got a new batch (which I lost at a music festival ), and I took 2mg as an attempt to microdose. I overshot that and had a pretty hectic day at work. It's not that it was overwhelming, it was just so THERE. Made communication difficult and I even had light visuals.

 

[Bigazznugz]

Is microdosing 2ce a good way to introduce yourself to 2cs? I have some but honestly I don't want all that nausea that comes with a regular dose. I have always been interested in 2cs I just have never gotten into them and seems the best ones are long long gone (2ct7) (2ci)

 

[spikeycloud]

There's been a few times in my life (not too too many.. but a few) where I ate 2C-B every single day or almost every single day. I miss doing it quite regularly... even though I'd prefer to do it somewhat regularly like once a week or so these days if I had the option. I highly doubt there's a correlation between PE & 2C-B or even D for that matter; but everyone is different. There's a few Ted Talks on sexuality that might be interesting to look at. The human brain is pretty much the most important sexual organ. Things like Pornography can affect the way you operate sexually. Daily habits involving sexual thought can affect things like that as well.

Maybe there is not direct correlation. But taking it 1-2 times a week for a year or two (around 100-150 doses of 3-10 MG those two years). can mean serious receptor down regulation. And I believe that serotonin plays a big part in how long you can last. If you take a SSRI for an example you last a lot longer.

I tried a lot of things to get rid of PE. Like Pelvic exercises, more exercise, healthier diet but it does not seem to change anything. Only on amphetamines I can last a lot longer but I cannot take those anymore.

Edit:

And it is not only that, I feel very different for sometime now that I forced to think and believe things that are not chosen by me. Which makes me feel very alienated. I think that the 2Cx did that too but not sure.

 

[FractalMe]

What if it only causes the mechanical issues you are experiencing and the mood issues are from the PE not directly the 2c? I'd be very upset if that happened to me, being satisfied sexually is definitely a big part of our most core desires.

Edit: Essentially what the post before me explained (in much better detail)

 

[spikeycloud]

What if it only causes the mechanical issues you are experiencing and the mood issues are from the PE not directly the 2c? I'd be very upset if that happened to me, being satisfied sexually is definitely a big part of our most core desires.

Edit: Essentially what the post before me explained (in much better detail)

That is a very good point you bring up. That is indeed a core desire of me as well. I'm very afraid not being able to have good sex anymore. Unfortunately I have not found a way to fix it just yet.

 

[The Hypnotist]

Yesterday was my first time microdosing anything. Took 500ug 2C-E yesterday. Had some in solution in the fridge and the idea crossed my mind. Felt some clear change in consciousness. Some kind of increased alertedness mix with some restlessness. Not a very useful state to be in. A bit like first signs from proper trip never developing. Body feeling was reminiscent of tripping though in a very weak level. Could feel my salivation increasing, and minimum unrest in the stomach which felt a bit uncomfortable. Probably I should go under 500ug for its nootropic effect.
Didn't see much point in the state so I ended up staking some 3-meo-pcp on top which was definitely wilder on top of that...but that's another story. I'll post later in the 3-meo thread what I found relevant.

 

[Xorkoth]

I've tried microdosing on 2C-E and I don't like it for that purpose, 2C-E is too strong or something. I'd recommend LSD/lysergamides for microdosing or you could try 250ug of DOC. I bet 2C-C would work too, and I'm pretty sure 2C-D is legendary for low/micro dosing as a nootropic-style substance.

 

[spikeycloud]

I've tried microdosing on 2C-E and I don't like it for that purpose, 2C-E is too strong or something. I'd recommend LSD/lysergamides for microdosing or you could try 250ug of DOC. I bet 2C-C would work too, and I'm pretty sure 2C-D is legendary for low/micro dosing as a nootropic-style substance.

I recommend 2C-D more than C because 2C-D has no nausea IME.

 

[Xorkoth]

I find 2C-C to not have any nausea either, but it does seem that the general consensus is that 2C-D is the easiest on the body of the 2C-Xs.

 

[The Hypnotist]

I've tried microdosing on 2C-E and I don't like it for that purpose, 2C-E is too strong or something. I'd recommend LSD/lysergamides for microdosing or you could try 250ug of DOC. I bet 2C-C would work too, and I'm pretty sure 2C-D is legendary for low/micro dosing as a nootropic-style substance.

It makes sense what you say. You probably talked me out of even exploring lower dosages. I just did it because this thread triggered my curiosity and had it within a hand's reach. If I ever try again I would probably go for LSD

 

[spikeycloud]

I find 2C-C to not have any nausea either, but it does seem that the general consensus is that 2C-D is the easiest on the body of the 2C-Xs.

Om what doses do you take C then? I want to mention that I have a special vendor where you can only buy stuff if you know someone else there. They have extreme quality. I can feel from their 2C-C on doses as little as 2 MG.

2C-D seems indeed the most easiest on the body. Though I still suspect that I you take it 150 times in 2 year it can down regulate your serotonin receptors big time.

 

[Cotcha Yankinov]

As we know, 2CX are serotonin anogist and those are believed to downregulate receptors. Does this mean that if you use them a lot they can cause depression as well?

Even though 5-HT2A activation with psychedelics helps depression for many, I wouldn't run that logic in reverse and assume that 5-HT2A downregulation would lead to depression. Mainly because psychedelic's activation of 5-HT2A is kinda special, and activation of 5-HT2A with endogenous serotonin may not be as "mood lifting", in the short term or long term.

5-HT2A receptors do provide excitatory input to many mood related brain areas but there are certainly drugs that block 5-HT2A that help with depression, so one has to question just how important having fully online 5-HT2A receptors is for mood, or if a little downregulation with psychedelics wouldn't matter.

Its also possible that some of the emotional blunting seen at the beginning of SSRI use (before 5-HT2A desensitizes) is due to 5-HT2A over-activation, and that psychedelic's desensitization of 5-HT2A is therapeutic.

In many cases, overexpression of 5-HT2A receptors seems involved in the pathology of depression or is at least noted in depressives, and chronic use of SSRIs downregulates 5-HT2A therapeutically.

Its also possible that some desensitization to the effects of psychedelics aren't occurring solely due to 5-HT2A downregulation.

However, long term overuse of psychedelics can.. strain the psyche. Do watch yourself, and practice mindful meditation (which combines lovely with psychedelics).

 

[Xorkoth]

Om what doses do you take C then? I want to mention that I have a special vendor where you can only buy stuff if you know someone else there. They have extreme quality. I can feel from their 2C-C on doses as little as 2 MG.

2C-D seems indeed the most easiest on the body. Though I still suspect that I you take it 150 times in 2 year it can down regulate your serotonin receptors big time.

I have the same 2C-C. I take 30-40mg normally. I took 10mg yesterday and felt it for sure but it was very mild.

It's worth noting that when I first started experimenting with these things, I got horrific nausea on the come-ups, I remember I puked 10 times in a row from 2C-I the first time I took it. For some reason over the years I don't get that at all anymore, not even from AMT which is notorious for nausea at first. 2C-I doesn't even make my stomach twinge, nor does 2C-C or basically anything else. So I may be a bit of a freak.

 

[spikeycloud]

Even though 5-HT2A activation with psychedelics helps depression for many, I wouldn't run that logic in reverse and assume that 5-HT2A downregulation would lead to depression. Mainly because psychedelic's activation of 5-HT2A is kinda special, and activation of 5-HT2A with endogenous serotonin may not be as "mood lifting", in the short term or long term.

5-HT2A receptors do provide excitatory input to many mood related brain areas but there are certainly drugs that block 5-HT2A that help with depression, so one has to question just how important having fully online 5-HT2A receptors is for mood, or if a little downregulation with psychedelics wouldn't matter.

Its also possible that some of the emotional blunting seen at the beginning of SSRI use (before 5-HT2A desensitizes) is due to 5-HT2A over-activation, and that psychedelic's desensitization of 5-HT2A is therapeutic.

In many cases, overexpression of 5-HT2A receptors seems involved in the pathology of depression or is at least noted in depressives, and chronic use of SSRIs downregulates 5-HT2A therapeutically.

Its also possible that some desensitization to the effects of psychedelics aren't occurring solely due to 5-HT2A downregulation.

However, long term overuse of psychedelics can.. strain the psyche. Do watch yourself, and practice mindful meditation (which combines lovely with psychedelics).

The problem I have is that I'm feeling tired and mind foggy almost the whole day and it feels like that a completely different thinker takes me over a lot of the time. I know I should see things more positive but it seems that the mind is forcing me to think negative about almost everything it is not even a choice that I make it just happens without my consent That also count for the complete identification with those thoughts. Even though I know they are not true, the moment I'm identified with them it is my reality it is really bizarre. You prob can understand that this can be very annoying if it happens every 5 seconds or so (on a bad day). And before mindfulness I was not even aware of this I thought it was how things are for me.

First I thought that these autmatic indentifications were due 4fa and 3fa. But last time is almost 3 months ago. It is close to impossible to still have a hangover from that. I think it is mental exhaustion. Because I can do interval cardio for 45 min after each other no problem.

I'm eating healthy, I'm exercising, stopped eating sugar, doing sometimes meditation. But it just will not get away. So I thought the 2cx could be the culprit

 

[Cotcha Yankinov]

I think you stand a lot to gain by learning to apply mindfulness throughout the day, unfortunately I don't think a strong inner monologue is helpful to many people with depression

 

[spikeycloud]

I think you stand a lot to gain by learning to apply mindfulness throughout the day, unfortunately I don't think a strong inner monologue is helpful to many people with depression

True if I have less inner talk I feel better. Though meditation has not really made it less and that makes it hard to keep doing it daily. Esp because I find it extremely boring to do. But I will try to do it more.