1p lsd

[markosheehan]

Is 1p LSD as safe as regular LSD. I can only get my hands on it and I want to try it but only if it's as safe as normal LSD. I heard that if you leave it in serum that they can detect LSD.

 

[Xorkoth]

It should be just as safe, as it gets converted into LSD in the body. I mean it's quite new, so no one can say for 100% sure I suppose. 1A-LSD, or ALD-52, was first synthesized long ago and seems equally as safe as LSD, and it behaves basically the same, it's converted into LSD in the body.

 

[markosheehan]

Generally when you add a propionyl group to a medicine is it safe does anyone know. ? If it's supposed to be similar to LSD why am i hearing it's only 50% as potent

 

[Cudi]

Similar in effects but not in potency. Yes, Solipsis is correct in saying it gets converted to LSD in the body, but something like only 30% is converted into LSD, not all of it. This is probably a reason for the potency difference

 

[cj187]

There was a study on 1P-LSD that found it to be 38% as potent as LSD in mice. The paper also states that 1P-LSD is converted to LSD in humans, but it doesn't say how much of it or how quickly. I think most or all of it is converted to LSD in humans because LSD and 1P-LSD are similar in potency for most people. It varies from person to person though. There is a minority of people who need a much higher dose of 1P-LSD.

I haven't seen any information about the toxicity of 1P-LSD, but there have been experiments on the effects of ALD-52 on rabbits, and it was found to have a much higher lethal dose and less of an effect on body temperature.

 

[markosheehan]

If not all of it is converted is 1p active by itself. And why was the LD 50 of ald 52 higher

 

[LlewellynDrury]

...but there have been experiments on the effects of ALD-52 on rabbits....

White rabbits??? Go ask Alice I think she'll know...

 

[Hodor]

If not all of it is converted is 1p active by itself. And why was the LD 50 of ald 52 higher

David E. Nichols (who is basically *the* expert on the pharmacology of psychedelics) stated that as long as the propionyl group is attached, it should prevent 1p-LSD from interacting with the receptor.

Also, keep in mind that there are some pretty significant differences in psychedelic potency between species (ex.: AL-LAD being stronger than LSD in mice, but weaker in humans).

In general, most human users will agree that 100 µg of 1P-LSD = approx. 100 µg of ALD-52 = approx. 100 µg of LSD-25.
Lastly, street LSD blotters are often severely underdosed, so 200 µg of 1p might actually be *stronger* than 200 µg of street Acid.

Generally when you add a propionyl group to a medicine is it safe does anyone know?

Did you ever try swiss cheese? If you did, and you aren't dead yet - there's your answer.
(swiss cheese is made using propionic acid-producing bacteria)