Opioids 14-methoxy opioids?

[LikeADaVinci]

I was wondering if anyone has had any experience with 14-Methoxymetopon, or any other 14-methoxy-substituted opioids?

From the literature, it seems that a 14-methoxy moiety confers a 500 fold increase in potency, and 100 fold increase in binding affinity from the parent compound, along with less respiratory depression?

Any experience? Can anyone find any literature on, say, 14-methoxy-codone (the 14-methoxy analogue of oxycodone?)

Thanks,

LikeADaVinci

 

[someguyontheinternet]

This sort of thread may do better in the neuropharm subforum but I'm definitely interested in hearing about this. Is the 14-MeO moiety involved in g protein bias?