100mg of Oxycodone a day tolerance. Why does hydromorphine(ORAL) feel so light

[Delmonte421]

So I have been taking one 80mg oxy in the morning and maybe 30mg in the afternoon and thats it. I have been really doing well with learning to restrict myself and the withdrawals on 100mg a day are not that bad, but not nothing. I took 24mg of hydromorphine at lunch and it took an hour to an hour and a half to take full effect and its very light and this is 12 hours after my last opiate. I would have figured it to metabolize quicker

 

[AlsoTapered]

Hydromorphone is not 100% cross-tolerant with oxycodone. In fact, it would appear that they bind differently (that 14-OH I presume). You can take a heck of a lot of morphine or hydromorphone to stop withdrawal if you are dependent on oxycodone. In fact, I believe that you can wind up being dependent on both.

If your doctor switches your opiate, they will give 25-50% less that the equipotent dose because their isn't 100% cross-tolerance.

 

[Delmonte421]

switched back to oxy, took a half 80mg ER but crushed it so made it IR, and half a 30mg IR (T-189). I felt the euphoria in minutes (subliminal absorption?) and within 20 already felt the "high"
hydromorphine doesn't seem to give me any euphoria that isn't forced.

 

[Delmonte421]

So today I woke up 1am( I fucking have the worst sleep) took an 80mg and 2mg xanax... at 12pm I took 24mg of hydromorphine and now like an hour ago I ate 55mg and got a very nice buzz. I got myself down to between 150-90mg a day with 3mg xanax which I am very happy with cause its affordable

 

[ColoradoOpiateGirl]

My chronic pain doctor makes me choose between my benzos script and him. He WILL NOT prescribe me opioids while I'm also being prescribed benzodiazepines simultaneously, to cover his ass. That's a lot of potentiation. Do you have a smart watch or a way to monitor your vitals, narcan, a wife/roommate/friend to be with you? Lol I'm a nervous Nellie always have been, but especially chewing the ER makes me concerned for you. I once did that and think I almost died lol.

I'm sorry the hydromorphone is feeling useless and you're not sleeping well. Hope you feel better soon and stay safe!

 

[G_Chem]

Hydromorphone is usually horrible bioavailability orally. From my experience, 24mg orally wouldn’t touch a 100mg a day oxy habit. I actually had a similar habit at one point and tried something similar only snorted them, didn’t feel much.

-GC

 

[Delmonte421]

do opiate conversion charts not take into account bioavailability or does it assume 100% on all opiates.
Like today, I just got up, 55mg oxycodone and 1mg xanax will need to hold me over until lunch where I have 16mg of hydromorphine then a 30mg oxycodone for dinner. Fucking sucks, I have job interview in another country tomorrow and I gotta hop a flight tonight.

Conversion chart would have me believe that 16mg of hydromorhpine is equal to 4 times it amount while oxycodone is only 3... so is hydro really only 1 since its bioavailability, for easier mathsssssss, 25% making 4/4=1 ?
SOURCE

Im new to opiates and any help would be greatly appreciated. I grabbed a bunch more hydromorphine, cause there cheap and work for WD. I got a bunch of 20mg guys coming and 80's. I got myself down to 90mg a day from close to 300mg a day, on real bad days. I would love to take 24/48 hours completely off but I wake up real sick and its too easy to reach for a ir oxy then kratom every morning.