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Opioids Question about Opana - Bioavailability (fatty meal vs. snorting)

A

Angel789

Greenlighter
Joined
Apr 20, 2011
Messages
1
Hello all!

I am new to bluelight so first I want to say if this thread is in the wrong place I apologize. I really enjoy this site as it has so much useful information on being safe!

I have a question about Opana ER that I am hoping someone can help me with. I have read on here that the bioavailability of Opana ER, when taken orally, is 10% and that when taken with a fatty meal it goes up to about 40-45%. I also have read that insufflating opana ER has a bioavailability of 40-45%. Why is it that most people prefer to snort this medication rather than eat it with a fatty meal? Won't it come out to the same amount in your system?

Isn't it the same to insufflate three a day as it is to take three or four a day with a fatty meal?

I'm basically wondering what is the difference and I'm curious as to why snorting is so much better. Also, if anyone has any comparisons I would be happy to hear them.

Any feedback would be appreciated and thank you in advance!
 
i think most people (myself included) just like to snort things. thats definitely part of the addiction, and yes the Bioavailabiity is much higher. snort it with a big mac, or on top of one, just watch out for the sesame seeds (kidding)
 
hahaha snort it off top of big mac .... funny

iv been told opana aint that much fun of an opiate anyway but thats just me

my fav buzz is/was hi-dose codeine cwe with potentiators and a woman ( but i dont do it no more (( cwe , not the women )) ) tried cpl times but failed since on `done, and iv tried everythin from codeine to i.v gear , it all started with oxys tho my cuz got for broke finger , mmmm oxy my best worst enemy
 
i thought the whole fatty food thing just increased the dumping mechanism of the opana ER time release. I didnt think it actually increased the bioavail of oxymorphone itself, if it did wouldnt there be tons more ODS.....?
 
Been using Opana for a very long time now and snorting is the way to go IMO, ER or IR. The fatty meal thing I dont ever do anymore, it just didnt compare to me. Ive always preferred snorting to eating also when I used oxycodone. Some people love eating them, I just dont get the same feeling as I do when snorting, it may have to do with the drug entering the system at a faster rate, who knows. You just have to try both and decide, its an individual thing as always with opiates. But IMO railing gives the best feeling outside of IV.

Good luck.
 
Why would you wanna eat a fatty meal if you are conscious about eating healthy. I try to eat healthy & the last thing I would do is eat a fatty meal just to get a bit higher off of a pill. Just snort the pills & eat healthy, then again, who said snorting pills is a healthy way to do it.
 
ok i been lookin for a opana megathreaad or some sort of thread to get some questions answered i figued this would be the best bet

ok i been pretty much clean for 3 months (other then a minor slip) and i used subutex to get clean
and i also found out that the sub actually helps good for my pain (i have chronic back pain)
so after i got clean i still kept gettin subutex here and there i usually do on avg. 2mg a day
but the only reason i bring that up is i got a 20mg opana ER i been sitting on for a min
and i want to use it and i want to get the best results out of it ...i took my small dose of bupe like 20
hours ago and ima bout to pass out so it will be tomorrow before i attempt to do the opana 20

so heres my questions ...

1)being that i dont use large amounts of bupe and its gonna be over 24 hours i should be ok
to take the Opana ?
2)ok i been reading alotta shit on here about ways to take these and bio. and i figure im going
to snort it..and i will take the coating off without getting it wet this should be best way?
3)i keep reading i need to eat a fatty meal ..ok i guess i will make a breakfast of eggs and eat cereal
and what ever else junk food i can find.. can i snort my opana then eat the food ..or must i eat first
then wait so long before taking it?
4) and finally i read somewhere there is certain things/pills i can take prior to my takin of the opana to intensify it ....like benadryl (is this correct??)

any answers would be great as i plan on doing this tomorrow in the mornin in between 10-noon
 
Although the bioavailability of a drug is an important factor, people often fail to take into account other important pharmacological values when they are considering how to administer their drugs.

Yes you want the best bang for your buck, but the best bang is not necessarily the highest B.A. When it comes to oxymorphone you can eat it with a high fat meal to bump up the B.A. to about that of snorting, but the time to peak concentration will be longer and the actual peak concentration itself will likely be much lower. The snorting ROA might have a lower B.A. but you will likely get much higher, just for a shorter amount of time.

Consider the following graph showing concentration of drug with time by different ROA, and you can approximate the IV administration as like to intranasal. The AUC (area under the curve) represents the Bioavailability.

220px-AUC_IVPO.svg.png

Although in this case the IV AUC is greater than oral, it is not hard to imagine if PO had an equal AUC without ever rising above a concentration of 50.
 
From mega thread. I wrote this up.

I had to sign up and post what I've collected. The information everyone has provided has been VERY unclear and VERY mixed. Here's What I've gathered from about forty different posts in the thread regarding conversions, dosage, etc.

The nasal bioavailabilty of oxymorphone is ~43%

Anyway, 100mgs insufflated oxy is equal to about 25-30mgs insufflated oxymorphone and around 15-17.5mgs IVed.

100/25 = 4x 100/35 = 3x

ok, i tooted about 10mg up the nose, I feel like a champ right now, a little gel i noticed hmmm, but ill let ya know how I feel in a little while, and my opiate tolerance is about 75-100 mg hydrocodone daily or every other day for 1 year, also an ocassional OC, oh and also tramadol daily. Another question too, is the WD from these gonna be ungodly?

Yes i have taken it, 5 mg, and it worked great, that was with approx. a 60 mg tolerance to oxy.
IMO it is more effective than oxy
just becareful with it, its strong 5 mg was a lot for me, i was throwing up the whole night

4 TIMES STRONGER THAN OC, so whatever your OC tolerance is divide my 4, example if u are use to 40 OC then only insuffulate 10 mg Opana

60-80 mg of OC to get a nice nod where as it only takes me 20 mg of Opana ER to do the same,

oxymorphone is atleast 5 times stronger then oc when they are both snorted.

nasal oxymorphone about 6x the potency of oxycodone. However, if it is opana ER then the time-release matrix/gel may affect this to lower it a little, but still I would imagine even then it should be at least 3-4x the potency of oxy if snorted properly.

100% certainty that 10mg of Opana ER, snorted properly, should be roughly equivalent to 60-80mg of oxycodone.

10mg-ish has me feeling quite nice. Pretty equivalent to 30mgs Perc.

Opana is around 3-8 times more potent than oxycodone when sniffed

Snorted its about 4 to 6 times stronger than oxycodone

10mg of Opana ER will get me feeling better than 40mg OC and for longer.

Opana is 2.25 to 2.5 times as potent per mg compaired to Oxycodone (any form).

If you can get off on 30mg of hydrocodone, I wouldn't mess with more than 5mg of opana at a time.

5mg snorted for me right when I started and had barely any tolerance would put me in a state of intense euphoria, pleasure, calm, ease, chilled ecstasy.

When snorted, approximately a 20-45% bioavailability.

3X-5X as potent as oxycodone. Euphoria wise, I would say 5X-7X.

OM is about 4-5x as strong as OC

Opana is supposedly 4-5 times stronger

i would say 4-5mg of intranasal opana off of a 40er is equal to about 20mg of oxycodone,

3-6x more potent

15mg OM (nasal) x 43% (BA) = 6.45mg OM (in the blood).
15mg oxymorphone snorted is equal to 64.5mg morphine in your system

10mg (snorted) opana about equivilant to 50 mg (oral) oxy. = 1mg = 5 ox oral, 2mg = 10mg ox oral
Intranasal is like 5:1
Click to expand...

Regardless of all these posts, I've determined here's the correct factor.

1mg of OM snorted = 5mg - 7mg OC snorted.
2mg of OM snorted = 10mg- 13mg OC snorted.
3mg of OM snorted = 15mg - 19mg OC snorted.
4mg of OM snorted = 20mg 27mg OC snorted.
5mg of OM snorted = 25mg - 31mg OC snorted.
10mg of OM snorted = 50mg - 57mg OC snorted.
20mg of OM snorted = 100mg OC snorted.
40mg of OM snorted = 200mg OC snorted.

Based on experience in terms of OM - OC snorted

It can range from 3-5X stronger. Depending on how much you eat before, etc. If you drink expect this to increase to around 5-7x.

Nasal Bioavailabilty

The nasal bioavailabilty of oxymorphone is ~43%, depending on user and how snorted (43-51)

OPANA IR VS OPANA ER

IMPORTANTThis will affect how strong of a reaction you get because one the ER will gel in the nose, however it's NOT bad at all, it's barely noticeable. Please realize that this minimal GEL will release slower in the nose vs the IRs. So If you don't feel anything right away, realize if your snorting 5mg + at once depending on pill size it's going to gel a bit and dissolve slowly over time. With some running down the throat and dissipating in the stomach. With the IRs you aren't going to see any gel, and it's going to be a normal powdered pill. Expect the reaction to be faster and you can determine if you need more sooner.

For First time and new Users

An acceptable dose is around 2-3mg. Some people say 5mg but they don't convert it out right, and realize other users have been getting sick of 5mg to start. Start with 2mg wait 30 min, then finish off another 1-2mg more if you're not feeling anything. People will say why so low, well you can never go to low but you can ALWAYS do too much. Also if you're new to opiates, or not tolerant and have never tried opana, you SHOULD start low anyways to get a feel for it. Opana can be and is a very strong drug, be careful and don't push it.

Lastly, not a doctor, etc. don't take my word for any of this, not going to be held responsible, use at own risk
 
Regardless of all these posts, I've determined here's the correct factor.

1mg of OM snorted = 5mg - 7mg OC snorted.
2mg of OM snorted = 10mg- 13mg OC snorted.
3mg of OM snorted = 15mg - 19mg OC snorted.
4mg of OM snorted = 20mg 27mg OC snorted.
5mg of OM snorted = 25mg - 31mg OC snorted.
10mg of OM snorted = 50mg - 57mg OC snorted.
20mg of OM snorted = 100mg OC snorted.
40mg of OM snorted = 200mg OC snorted.

Based on experience in terms of OM - OC snorted

It can range from 3-5X stronger. Depending on how much you eat before, etc. If you drink expect this to increase to around 5-7x.

Nasal Bioavailabilty

The nasal bioavailabilty of oxymorphone is ~43%, depending on user and how snorted (43-51)


I have to say 40mg Opana=120mg OC.. I was blasting 3 40s a day and taking over 60mg of valium or 10mg xanax....When I tried to go back to OG OCs I could not get high off an 80, it took two to feel a nice warmth...hydrocodone, LOL forget about it, took about 190mg before my liver would basically cry for me to stop and drinking was a part of life, so three to six beers....Opana is THE hardest nodd besides the real deal holy field HHHHHH.
 
PS I have had GOOD friends WITH TOL who snorts 40mg and then they throw up immediately! I gave a good friend a yellow stopsign and he tooted it all to the dome and 15min later spilled his glass of water onto himself nodding off, LOL so funny
 
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