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Weak DRI + Weak dopamine releaser = Euphoria?

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doctordre

Greenlighter
Joined
Oct 12, 2010
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42
Would the combined effect of a weak dopamine releaser plus a weak dopamine reuptake inhibitor all result in some sort of euphoria?

Edit: As a weak DRI, I'm thinking of benocyclidine, a non-neurotoxic PCP analog. As a weak dopamine releaser, I'm thinking of cathinone.
 
this combo would likely lead to more unpleasant stimulant effects than euphoria.
 
I was under the impression the BTCP has more evidence of it being toxic than evidence for safety?
 
In my experience, this leads to exacerbated cardiovascular effects with euphoria attenuated in comparison to what one would expect additively.

ebola
 
Forget the actual substances I referred to (BTCP and cathinone).

What about the theoretical idea? A dopamine releaser would obviously release some dopamine. A reuptake inhibitor would keep all that dopamine active. Wouldn't that cause a stimulating euphoria?
 
^ No, see what ebola said.

I don't understand the concept of a DRI "keeping all that dopamine active," to be honest :).
 
doctordre said:
Forget the actual substances I referred to (BTCP and cathinone).

What about the theoretical idea? A dopamine releaser would obviously release some dopamine. A reuptake inhibitor would keep all that dopamine active. Wouldn't that cause a stimulating euphoria?
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Like doing meth and coke together? Yes, very euphoric. Until you die.
 
the only drug that does both these things and is in my experience overwhelmingly euphoric is alphamethyltrypatime

trying to make a combo involving cathinones seems stupid as for the most part bar mephedrone they aren't all that euphoric...

i used to do speed and coke together but looking back coke on its own was much better
 
If it weren't the case that known releasers also acted as reuptake inhibitors, there would be greater theoretical chance of synergy (but who knows if there'd be a synergistic increase in desirable effects).

ebola
 
well i normally do meph and afterwards 4-fa which is said to be DRI and it has not felt any worse than combing just dopamine releasers. The same goes for meph and mdpv combo,
 
Hammilton said:
have you tried mcat? not bad by any standard
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no, but
my experiences with mephedrone and methylone also buphedrone (ethcathinone was so shit it doesn't even come into it) have put me of cathinones, buphedrone was the least rough but just turned into a wank fest (literally)

i prefer drugs that give me more than just rampant stimulation these days, but thats just personal preference. though i do love coca tea, but its more for functional things like singing, driving and swimming than wankathons
 
Is there such a thing as "dopamine syndrome" in the same spirit of serotonin syndrome? Serotonin syndrome generally comes from an SSRI/serotonin releasing agent + MAOI. So would a DRI/dopamine releasing agent + MAOI result in "dopamine syndrome"?

Just talkin out of my ass here.
 
^ Yes, hypertensive crisis.

Basically similar to the "cheese syndrome".
 
Fencamfamine is a pretty good stimulant according to some people.
 
Having a mechanism of action somewhat between release and reuptake inhibition is a vastly different affair from combining two separate agents.

ebola
 
dread said:
Fencamfamine is a pretty good stimulant according to some people.
Click to expand...

Some experiments also suggest a role for opioid receptors in the activity of fencamfamine, as low doses can cause paradoxical sedation, and some effects of the drug are blocked by naloxone.
Click to expand...

I'll bet! Sign me up for some 3-methoxy-fencamfamine.
 
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