nuke
Bluelighter
- Joined
- Nov 7, 2004
- Messages
- 4,191
A thread about this compound; curious if anyone's tried it.
EC50 NE release (nM) 16.1 ± 1.7
EC50 DA release (nM) 24.2 ± 1.1
EC50 5HT release (nM) 1,937 ± 202
Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, Woolverton WL. Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs. J Pharmacol Exp Ther. 313(2), (2005) 848-854.
From the following paper:
Heather L. Kimmel, Daniel F. Manvich a, Bruce E. Blough d, S. Stevens Negus e, Leonard L. Howell "Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey" Pharmacology, Biochemistry and Behavior 94 (2009) 278–284.
It is apparent that despite having EC50 values above those of d-amphetamine for dopamine release, 3-Fluoroamphetamine can elevate basal levels of dopamine roughly three times higher times compared to amphetamine at the same mg/kg dosage in Squirrel Monkeys. That's over 1500% or 15-fold. The levels drop quickly after administration but always remain at least two-fold above the amount produced by amphetamine.
EC50 NE release (nM) 16.1 ± 1.7
EC50 DA release (nM) 24.2 ± 1.1
EC50 5HT release (nM) 1,937 ± 202
Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, Woolverton WL. Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs. J Pharmacol Exp Ther. 313(2), (2005) 848-854.
From the following paper:
Heather L. Kimmel, Daniel F. Manvich a, Bruce E. Blough d, S. Stevens Negus e, Leonard L. Howell "Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey" Pharmacology, Biochemistry and Behavior 94 (2009) 278–284.
It is apparent that despite having EC50 values above those of d-amphetamine for dopamine release, 3-Fluoroamphetamine can elevate basal levels of dopamine roughly three times higher times compared to amphetamine at the same mg/kg dosage in Squirrel Monkeys. That's over 1500% or 15-fold. The levels drop quickly after administration but always remain at least two-fold above the amount produced by amphetamine.