3-Fluoroamphetamine

[nuke]

A thread about this compound; curious if anyone's tried it.

EC50 NE release (nM) 16.1 ± 1.7
EC50 DA release (nM) 24.2 ± 1.1
EC50 5HT release (nM) 1,937 ± 202

Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, Woolverton WL. Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs. J Pharmacol Exp Ther. 313(2), (2005) 848-854.

From the following paper:
Heather L. Kimmel, Daniel F. Manvich a, Bruce E. Blough d, S. Stevens Negus e, Leonard L. Howell "Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey" Pharmacology, Biochemistry and Behavior 94 (2009) 278–284.

It is apparent that despite having EC50 values above those of d-amphetamine for dopamine release, 3-Fluoroamphetamine can elevate basal levels of dopamine roughly three times higher times compared to amphetamine at the same mg/kg dosage in Squirrel Monkeys. That's over 1500% or 15-fold. The levels drop quickly after administration but always remain at least two-fold above the amount produced by amphetamine.

 

[Sturnam]

Haven't tried it, but might be worried about the levels dropping too quickly. Sounds like that could easily cause a nasty crash with compulsive re-dosing. I'm just reminded of a book on addiction neurobiology that states that the 'crash' from crack comes while cocaine blood levels are still really high.

Do they papers give any idea how long it takes for blood levels to drop, and by what %?

 

[pofacedhoe]

is that more dpamine than meth? because even if it faded out slowly dopamine dropping from a great height will always make you feel like shite.

 

[nuke]

is that more dpamine than meth? because even if it faded out slowly dopamine dropping from a great height will always make you feel like shite.

I'm pretty sure it is, but I don't have a source to back it up at the moment. I believe it's around 1200% for meth and 400% for cocaine. It doesn't include norepinephrine levels as well, which is problematic because if they're even higher the abuse potential might be diminished.

Haven't tried it, but might be worried about the levels dropping too quickly. Sounds like that could easily cause a nasty crash with compulsive re-dosing. I'm just reminded of a book on addiction neurobiology that states that the 'crash' from crack comes while cocaine blood levels are still really high.

Do they papers give any idea how long it takes for blood levels to drop, and by what %?

It's included in the figure. Keep in mind rats are pretty fast metabolisers.

For comparison
d-Amp
EC50 NE release (nM) 7.2 ± 0.44
EC50 DA release (nM) 8.0 ± 0.43
EC50 5HT release (nM) 1756 ± 94

m-Fluoroamphetamine
EC50 NE release (nM) 16.1 ± 1.7
EC50 DA release (nM) 24.2 ± 1.1
EC50 5HT release (nM) 1,937 ± 202

p-Fluoroamphetamine
EC50 NE release (nM) 28.0 ± 1.8
EC50 DA release (nM) 51.5 ± 1.7
EC50 5HT release (nM) 939 ± 76

This brings one to question the overall usefulness of release data as well, if basal dopamine increases in the nucleus accumbens don't appear wholly similar to the release EC50s. The question remains as to why 3-F-AMP would be stronger releaser of dopamine than any of the others, which is somewhat mysterious.

 

[BlueSwede]

Little info on this one - can contribute what little I have. Tried this twice, a couple of months back, dosage about 50-70 mgs, anal administration. No hard comedown/crash as feared above. Very pro-sexual. Tunnel focus, as opposed to the more "open" mental clarity of dl-amphetamine. I'd say equally or less euphoric. The sexual bit is what makes it stand out. I mean I get pretty horny off of regular amph, but that's a comparably tender feeling. This is pushier and more animal-like. So, not a study/work drug ... No side effects unpleasant enough to stand out and be remembered at this dosage.

 

[astenu]

Little info on this one - can contribute what little I have. Tried this twice, a couple of months back, dosage about 50-70 mgs, anal administration. No hard comedown/crash as feared above. Very pro-sexual. Tunnel focus, as opposed to the more "open" mental clarity of dl-amphetamine. I'd say equally or less euphoric. The sexual bit is what makes it stand out. I mean I get pretty horny off of regular amph, but that's a comparably tender feeling. This is pushier and more animal-like. So, not a study/work drug ... No side effects unpleasant enough to stand out and be remembered at this dosage.

What was the total duration of effects? 4-fa sticks around nearly 17 hours for me...am hoping 3-fa will be of shorter duration.

 

[yoyoman]

bump.

Any new info? It looks like something i would like to try, seems maybe an even better amphetamine substitute than 2-fa. I also wonder about the N-methyl versions..

 

[Amu]

bump.

Any new info? It looks like something i would like to try, seems maybe an even better amphetamine substitute than 2-fa. I also wonder about the N-methyl versions..

I was hoping 2-FMA would be a stronger and longer lasting version of 2-FA, with a bit more serotonin action but this does not seem to be the case, as the FMA's seem to have unusual pharmacological properties. Some reports do say it's more potent, but I think the overall "feel" is different.

 

[ebola?]

Yeah...this thread's' not about 2-fma. You should also be explicit about which sources of data you're drawing from to make your conclusions (even if they're preliminary...preliminary is okay with newly emerging compounds).

ebola

 

[yoyoman]

http://beherenow.dreamhosters.com/shulgin_index/

I was hoping 2-FMA would be a stronger and longer lasting version of 2-FA, with a bit more serotonin action but this does not seem to be the case, as the FMA's seem to have unusual pharmacological properties. Some reports do say it's more potent, but I think the overall "feel" is different.

Hmm well I wonder about 3-FMA, but 4-FMA and 2-FMA turned out to be "less good" than their non N-methyl counterparts so who knows.

I personally love to mix both 2-FA and 3-FA together (in the same syringe to IM, or same capsule). Instead of ~40mg of either one, 20mg/20mg i like a lot better.

Makes me wonder what 2,3-difluoroamphetamine would be like. I wonder if its in the Shulgin Index (here's a tease from someone elses cell phone, it shows 2-FA/3-FA and others, makes me want to buy the book!)

 

[kaskelot]

I have experience with 2- 3- and 4fa. 2-fa is so far the best study aid I know, at least if you don't have to take it for longer periods of time, therefor some DARI is the better option, at least for me. The stimulation is very mental, but there is also some euphoria - enough to be motivated to learn rather boring stuff, but not so much that you'll get distracted from your work easily. The duration is shorter compared to 3fa, which has more pros than cons.
With 3fa you don't get that clear-headed stimulation, it feels like it's releasing WAY more DA than NE. Therefore the mental stimulation is very calm, too calm in my opinion. It doesn't provide the same focus and that sharp and clear intellect 2fa does. In addition to that, the releasing of higher amounts of DA produces more craving and compulsive behaviour in my experience.
The comedown and hangover from 3-fa is compareable to that of 4-fa, although 4-fa has more to give in terms of euphoria and empathogenic effects. Besides 3fas legal status and the fact that it's more potent than 4-fa, I don't see any real advantages.

What doses have you been taking?