Ketamine salts solubility

[AlsoTapered]

(1R,5S)-9-methoxy-9-phenyl-3-(2-phenylethyl)-3-azabicyclo[3.3.1]nonane

(1R,5S)-9-methoxy-9-phenyl-3-(2-phenylethyl)-3-azabicyclo[3.3.1]nonane | C23H29NO | CID 21151698 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

BTW the above compound is an example of an opioid demonstrated to be over x100,000 morphine in potency.

If one has access to ChemOffice, it's worth overlaying the above compound with fentanyl, BDPC and similar compounds. The above compound hasn't seen optimization such as replacing the beta-aromatic with a 2-thienyl or 2-furanyl moiety or the addition of a chiral beta-hydroxy moiety.

But in a PM the Canadian BLer noted that researchers used OHMEfentanyl as a reference compound and were shocked to discover that even after 3 applications of OHMEfentanyl, the compound was not dislodged from the MOR receptors.

When we reach these levels of potency, Ki values are not measured in micromoles (uM) but rather in nanomoles (nM). I have mistakenly read affinity data ASSUMING the values were in uM only to discover upon closer examination that the values were in nMs.

The paper 'A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans'

Although the above paper ostensibly discusses antagonist, it's important to note that opiate ligands which display antagonist activity MUST include a meta-hydroxy moiety on the alpha aromatic (benzene) ring or bioisostere thereof.

 

[vecktor]

^ not a new compound at all. However the potency in vivo is nowhere near as high as is suggested by in vitro. ED50 32ug/kg in guinea pigs. In humans it is not that potent (fentanyl level potency)
Patent is 1972 to Sanko company, Chem Pharm Bull (Japan) 2050-2057 (1970)

I don't understannd this obsession with in vitro potency over everything, are you playing some kind of smackhead top trumps?

Safer opioids would be a good thing and super potent /= safer
Dezocine based compounds with reduced respiratory depression and or ceiling effect would be a better approach if harm reduction really was your priority

 

[Rectify]

MEANIE_GREENY
1-(3,4-dichlorophenyl)-1-oxo-2-(1-pyrrolidinyl)-pentane

 

[Rectify]

1-phenyl-2-methylaminopropane saccharate

50:50 Mix With

MIXED_TREAT
1-phenyl-2-methylaminopropane aspartate

1-phenyl-2-ethylaminopropane saccharate

50:50 Mix With

1-phenyl-2-ethylaminopropane aspartate

N-ETHYL
1-phenyl-2-ethylaminopropane saccharate

MDG
1-(3,4-methylenedioxyphenyl)-2-methylaminopropane gluconate

 

[Rectify]

3-(methanone-1-yl)indole

1-(indole-3-yl)-2-nitroethene

Then Tryptamine, Then DMT.

3-allyl-indole

3-(1-oxo-ethane-2-yl)indole

Then DMT Using Dimethylamine.

 

[Rectify]

 

[MedicinalUser247]

How bout this one. 2-(diphenylmethoxy)-N,N-dimethylpropan-2-amine.

 

[MedicinalUser247]

Here's another that basically the same 2-(diphenylmethoxy)-N,N-dimethylphenylpropan-2-amine.

 

[MedicinalUser247]

Here's another one 2-(3,4,5-trimethoxyphenyl)-1-phenylpropan-2-amine.

 

[Rectify]

Without posting a structure, it's really hard to picture all that.

FURIOUS_GEORGE
1-(furan-2-yl)-2-methylaminopropane

 

[Rectify]

MENDELEEV
1-(2,5-dimethoxy-4-bromophenyl)-1-oxo-2-(1-pyrrolidinyl)pentane

 

[Rectify]

HUCKEL
1-phenyl-1-oxo-2-(2-azaindan-2-yl)pentane

BITTER_SWEET
1-phenyl-1-oxo-2-(1,1,3-trioxo-1-thia-2-azaindan-2-yl)pentane

SYMPHONY
1-(3,4-methylenedioxyphenyl)-2-(1,1,3-trioxo-1-thia-2-azaindan-2-yl)propane

DESIGNER_SACCHARIN
N-methyl-5,6-methylenedioxy-1H-1,2-Benzothiazole-1,1,3-(2H)-trione

SUENOS_DOLCES
1-(indole-3-yl)-2-(2-azaindan-2-yl)ethane

RICO_SUAVE
1-(indole-3-yl)-2-(2-azaindan-2-yl)-1-oxopentane

CHEECH_n_CHONG
1-(1-pentyl-indole-3-yl)-2-(2-azaindan-2-yl)-1-oxopropane

 

[Rectify]

AcOH, HBr

NaN3

NaBH4, MeOH

 

[Rectify]

ENIGMAGICAL
3-(furan-2-yl)-3-(2-pyrrolidinyl)-acetone

AMAIZEING
3-(thiophen-2-yl)-3-(2-pyrrolidinyl)-acetone

BRIDGES_OF_DOPE
1-(furan-2-yl)-2-aminopropane

ERIS
1-(furan-2-yl)-2-ethylaminopropane

AVID_DIVA
N-allyl-1-(furan-2-yl)-2-aminopropane

INSATIABLE_INSURRECTION
N-allyl-1-(4-methylthiophen-2-yl)-2-amino-1-oxopropane

THE_VALIANT_VIKINGS
1-(4,5-dimethylfuran-2-yl)-2-methylaminopropane

G's_UP_HOES_DOWN
1-phenyl-2-(2-oxo-3-oxacyclopentylamino)propane

SID_CAESAR
N-(tert-butyl)-1-phenyl-2-aminopropane

JOY
1-phenyl-2-isopropylaminopropane

DES-O-MPH
3-phenyl-2-oxo-3-(2-piperidinyl)propane

Like Methylphenidate [MPH] sans the O in the MeO portion of Ritalin's carbomethoxy (R-(C=O)-O-CH3) functional group.

 

[Rectify]

ELLEN
1-(4-methoxyphenyl)-1-oxo-N,N-diethylaminopentane

STORMY
1-(3,4-methylenedioxyphenyl)-1-oxo-N-ethylaminopentane

HELEN_"MAMA FAYE"_KITCHENS_MCNAIR
1-phenyl-1-oxo-N-ethyl-N-hydroxyaminopentane

 

[Rectify]

AMP by Lazaru circa 1887
1-phenyl-2-aminopropane; phenylisopropylamine; AlphaMethylPHenylEThylAMINE or amphetamine.

The compound that started it up!

PERSPICACIOUS_PERSEUS
N-hydroxy-1-(4-methoxyphenyl)-2-methylamino-propane

PAN_HORUS
N-hydroxy-1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminopropane

Featuring The All-Seeing Eye Of Newt!

Barely Legal!!!

 

[Rectify]

SONIC_THE_HEDGEHOG
1-(1-oxocyclopent-2,4-diene-3-yl)-2-methylaminopropane

CHECKPOINT!

 

[Rectify]

There are an estimated 10^60th power of chemical compounds. Only 2% of them have been characterized so far.

I focus on dopamine, adrenaline, and serotonin analogs, using Sasha Shulgin's methodology as illustrated in PiHKAL & TiHKAL.

 

[Rectify]

MISS_DOT
1-(2,5-dimethoxy-4-(methylthio)phenyl)-2-aminopropane

 

[Rectify]

POOR_MAN'S_FENTANYL
N-(1-methylpiperidine-4-yl)-aniline

HYATT_WYATT
4-phenyl-4-(2-piperidinyl)-3-oxobutane

DOPER_ROPER
4-phenyl-4-(1-methyl-3-piperidinyl)-3-oxobutane