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  • Trip Reports Moderator: Xorkoth

~ Truly a Wonder Drug ~ Memantine ~

Id say that it would probably mix good with those, the only thing i have ever combined it with so far is GHB and that was really great. Id think that the Amphetamine in particular could be quite nice @G_Chem.

Today has been a little uncomfortable so far i got sleep last night, woke up at 9:30am with definite withdrawal symptoms mainly manifesting in the form of RLS but in my entire body. I just cant stop moving around its very irritating i will lay in a position and 30 secs later i just have to move its impossible not to.

In the grand scheme of things tho this could be way worse, i only took 50mgs today cuz im trying to get more back towards baseline. Might do one last big dose tomorrow but after that i will be dosing in the lower range as i get ready to go back to work in four days.

Just trying to rest and get through this transition to the Bupe as smoothly as possible. The Memantine really did make an amazing difference i would surely be in much worse shape right now without it.
 
Just took a hot shower for 30mins at least and i feel so much better now, its amazing how the hot water can help you out in this state like that. And then i put on thermal top and cozy pants and i think this is gonna help, i might just have been naturally cold it is twenty degrees outside. Its nice not having anything to do really and just being able chill out snd listen to music, probably gonna make a cup of tea in a few.

Thinking that tommorow i will do one last big dose like maybe 140mgs and then not take anything on monday/tuesday most likely. Induce the Bupe at some point during that period. So by the time wednesday rolls around i will be all set to head back to the kitchen and cook my ass off. This has all been going pretty smoothly, i was so nervous about making this jump from methadone but the memantine made very tolerable.
 
Memantine (40mg/d) + caffeine (just 1 usual cup) gave me feelings of overstimulation, I would not drink caffeine unless you have a serious tolerance/addiction to it. Cigarettes stop feeling pleasurable due to nicotinic acetylcholine antagonism of memantine - this can be a good thing, it's easy to stop smoking on memantine (or DXM, both of which block the same receptor as bupropion which is used to aid with stop smoking).
 
Well im used to using pretty absurd amounts of caffeine everyday, for instance i have capsules that are 100mgs caffeine/l-theanine each and i take three of those on days when im not drinking coffee and tea. If i dont consume caffeine i get headaches i have a pretty unhealthy relationship with it honestly and its a bit of a crutch for me at times. Like when i have to leave for work i 100% need to put caffeine in my system to get in the zone.

Drinking something mild like black tea doesnt really effect me to the point i would become overstimulated. But that being said i havent taken those caffeine pills whatsoever this past week the memantine has me pretty stimulated on its own. But its a smooth sorta uplifting feeling, im just kinda floating about the world today jamming to 80s musik, lovin it ❤️
 
I’ve got my hands on some now but the idea of a multiple day experience means I need to find the time. What’s a good starting dose to test the waters? 10mg? How inebriated will I be? Can I function at my job where I need to be able to think sharply and quickly?

-GC
 
10mgs is not gonna be inebriating whatsoever and you could go about life as normal. I dont think you will really feel all that impaired until you pass 40mgs at least in the sense that you wont be able to work. That being said i have a tolerance to dissos and can handle them out and about very well in large amounts compared to some.

Just start slow and work up and get a feel for it thats what i did. When i first took Memantine i did 20mgs and it just really enhanced my day and i felt real happy. Its a really strong antidepressant and works pretty much immediately in that regard. Its such good medicine, i wish i found it a long time ago.
 
Yeah, 10mg are on the low end. Remember that memantine works differently to most other dissociatives in that it isn't a full channel blocker (at lower dosages) and it needs some amount for it to behave like your usual disso. Some people get clouded brain at low doses though, probably due to the nicotinic antagonism. I never got that. But 40mg were really stimulating back in the day due to memantines D2 agonism possibly, I even got mydriasis from this dosage while nowadays it would do next to nothing due to permatolerance.

I was able to function even with more than 100mg of memantine but it kept me up all night until next afternoon. Was able to function on higher dosages of deschloroketamine also though so maybe I'm not the best guy to judge this. But insomnia from memantine is a real side effect (but then again, any dissos cause it). Only real disso effect I got at high dosages was drifting with eyes closed, no CEVs or even OEVs, no spiritual experiences etc. but I know people with less of tolerance compare memantine to DXM.
 
This stuff sounds like it could be a lot of fun for a festival. A long lasting stimulating disso type experience is exactly what I’ve been looking for. Something that can play nicely with MDMA and LSD.

-GC
 
Yeah i dont get any true visuals from it either aside from the world looking sorta liquidity when im on a huge dose. But like you @plumbus-nine im used to taking pretty monster sizer kinda dosed, like once i passed the gram mark with FXE during that binge last week i was having incredible visuals. But even on 160mgs of Memantine i didnt get any thing really significant.

But thats not saying i dont enjoy it, quite pleasurable drug in fact. I dont get a whole ton of visuals with the PCP analogs either generally until i get into silly 40mg+ dosage ranges. But for someone that doesnt use dissos like we do they might get strong visual effects from Memantine, ive read about it in reports.
 
Memantine helped me too. I detoxed from 80mg of hydromorphone over Christmas. I read about it here in the forum from Plumbus-Nine. Thanks very much!
I originally wanted to taper off the hydromorphone slowly. But then I got corona and didn't want to weaken myself with withdrawal. So on 12/26 I went from 80mg to 0mg.
Otherwise there would not have been enough time for me to recover.
Before starting, I got 4 scientific studies on opioid withdrawal with memantine. Two studies say it works, one study says it doesn't work, and one is undecided.
Unfortunately, I only had 120mg memantine that I took in 6 days. Additional I took 150 mg Lyrica/day. The withdrawal was not completely gone but very moderate.
It has had a very strong effect on me. I slept a lot and once I passed out on my way to the toilet. However, I would caution against taking huge doses of it. That can't be good, and with a half-life of 60 hours, it accumulates heavily.
Anyway, it helped me a lot!
 
Woke up feeling pretty bad this morning, took 100mgs little over an hour ago and just waiting for it to take effect now and give me some relief. Dont think 50mgs is enough to totally cover the withdrawals completely for 24hrs. Thankfully i was able to get a solid six hours of sleep tho which was a blessing. Mainly cuz the insomnia from higher doses of Memantine is the primary drawback from the substance. Wish i had some of my FXE on me right now cuz if i did two fat lines i know id feel so much better.
 
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Well i finally just induced the Buprenorphine, took 4mgs sublingually about an hour ago. Its been 7 days i think at least since i took any Methadone. For this reason i decided to stop the Memantine at this point, it worked wonders carrying me through this transitional period and made the whole process so much smoother than it could have been.

Im expecting it to potentiate the Bupe pretty significantly as well, im absolutely still under the influence of Memantine and its gonna probably be a few days before i am all the way back to baseline. Going to be taking a break from the dissos for a couple weeks and eventually will most likely do a recreational trip on 100mgs when i get the itch again.

This experiment was a great success overall and i hope that anyone reading this that struggles with Opioid Addiction could gain something by reading about my experiences with this compound. Wish you the best of luck on your journey, with all my love ❤️
 
Been feeling fine the transition over to Buprenorphine was seamless at 4mg, actually just saw the doctor today im having it raised to 8mgs primarily to help deal with chronic pain. If i really wanted to tho im sure i could have lowered the dose of Memantine to lke 20mgs and continued on that for a month or so and been of Memantine period. One notably thing is that it gave me a massive tolerance to the Memantine.

When i went to take 100mgs recreationally a few weeks later it was mild and i had to double the dose to 200mgs to get me the same effect as the former dose. Probably over did it staying on 100+mgs for so long but doing so took away all the dope sickness so i dont regret it. Just hoping that my tolerance dissipates over the coming months and that it also doesnt interfer much with my use of other Dissos.

But in the grand scheme it worked for me and i was using it for couple months in lower dosages before i went high for the jump off. If you do plan on doing this id suggest doing a high attack dose with the jump off and then tapering down over time. I was still feeling the withdrawals pretty bad during that week when id wake up and then Memantine wore off, and thats how i justified my dosages to myself.
 
Since today I am again in the process of withdrawing with Memantine.
I had already done that at Christmas, but I had too little memantine and not enough time to recover from the PAWS.
Since January 09 I have been taking 2 mg buphenorphine, which I have substituted for 32 mg hydromorphone since January 21.
Now my attempt no. 2:
This time I got myself more memantine. I still try to take as little as possible.
Today it was: 2x10mg memantine, 100mg pregabalin, 2mg clonazepam, 20mg Ritaline, 10mg amphetamine, 10mg zolpidem.
A wild mix, but it helps!
Now I still have 4 days to work - I am a self-employed management consult - and then fly to a wellness hotel in Portugal for 2 weeks.
My plan is to taper the medication to 0 within the next 7 days. Then I have to overcome the PAWS through sport and wellness, which is why I relapsed on my last attempt.
I'll report from time to time how it's going.
 
Here is a summary of my hydromorphone detox using Memantine.

I react very strongly to the memantine because otherwise I never take dissociatives. So in the last 6 days I took 10mg memantine in the morning and evening (in sum 20mg) , plus Lyrica in decreasing doses from 3x100mg to 2x50mg today.
I took 10mg of zolpidem to sleep - actually it wasn't necessary. I'm just an addict. Hardly anything is noticeable from the withdrawal. I was even working.

I know that Memantine works well because I tried to lower my dose of Hydromphone (~45mg drawn) the previous week.
At first it went quite well but when I had only taken 24mg I woke up at 4am with a bad turkey. It took me an hour to crush a pill. Then I could hardly get the stuff in my nose because it was dripping so heavily.
Then at 6 AM I felt like a human again and was able to go to work. I feel much better with the memantine - It's really very mild.

This is my 2nd attept. I got that far at Christmas. Then I stopped taking the memantine and got bad PAWS. I sat in front of my PC for 3 days and wrote 1 email - nothing else. I was completely un-energetic and unmotivated.
I am afraid it will be the same when I stop taking the memantine tomorow. But this time I took 10 days off and stayed in a sport and wellness hotel in Portugal.
If necessary, I will force myself to do aerobic-sports and sauna. I also take about 5 grams of Iboga rootbark ervery day.
The latest research has shown that this increases the formation of GNDF in the brain. I hope this helps me to build new neural connections.

But I don't have more time than these 10 days.
If I'm not fit again then I'll probably have to take something again.
But I don't want that and I'm doing my best to recover.

I'll report from time to time how it's going.

warm greetings from the Doc
 
Hello everyone,

so here is the summary of my second attempt to quit hydromorphone.
On February 1st, 2023 I stopped taking the hydromorphone. This time I took only app. 32mg per day i.N. I substituted it with 2x 10 mg Memantine and 2x150mg Lyrica. and 20 mg Diazepame.

I then weaned off these medications within 10 days. On the first 0 day I moved to a wellness hotel and forced myself to do aerobic sports and wellness (sauna) there. That was difficult but I did it mostly. Now, after another 9 days I'm back at home and I'm still "on the ropes".
What does I mean I couldn't overcome the PAWS. After two days of tortment I decided to take a small amount of hydromorphome (8mg) and now I can go back to work. Certainly part of it is also psychosomatic, so I'm cheating myself here.

Anyway. It didn't work and now I have to go to "plan B". I will first stabilize on a low level of HM and then go to a professional clinic for 6 weeks in early April. But that's my last try.
If that doesn't help, I'll take methadone for the rest of my life and just languish as a zombie.

I'm very sorry I wasn't strong enough, but that's how it is. I will report how it goes.

Greetings from Germany. From the Doc.
 
cosmic charlie said:
Ever since i began using this compound Memantine its benefited my life in so many ways, both with its therapeutic purposes and its recreational ability. To start off a little backround information, i have been an Opioid Addict for most of my life, over twenty years use of Narcotics. Well i got on Methadone a couple years ago and as time went by i escalated my dosage to 105mgs daily.

Well four months ago i decided i wanted to get off this stuff so i went about researching drugs that could help me in the process. One of the first things that came to my mind was Memantine, ive heard from a prominent and brilliant guy on one of the forums i frequent go on and on about how it eliminated his withdrawals. This obviously planted the seed.

So now i start to drop 5mgs per week and i get down to 40mgs without too much trouble but than that changes. I start to wake up everyday very sick and feeling like i got hit by a truck. Told them to halt my taper for the time being. Then it comes to me, find some Memantine and it could hopefully help i mean its worth a shot once it arrives in the mail i begin my taper once again.

Order my first couple boxes of tablets 120 of them that are 10mgs each. Begin taking two per day and within a couple days i notice a definite decrease in symptoms, like all of the classic ones and i feel right as rain. Now ive been going along and im down to 10mgs of Methadone a day and its been so much easier than before.

Im really grateful that i found this drug because i work full time at a physically demanding job, im a cook. And i dont think i would have been able to get through this without it and not needing time away from my job. Ontop of it has been really good antidepressant and when i take it i have noticeable reduction in symptoms from my bipolar and anxiety.

Now getting onto its recreational effects, i am a huge fan of Dissos and used pretty most of them that are available on the RC market at this point and the classic ones. Here is a list of what i have explores for perspective.

MXE
DMXE
MXiPr
MXPr
DCK
DXM
FXE
n2O
PCP
O-PCE
2F-DCK
Memantine
Ketamine
Ephenidine
3-MeO-PCP
3-MeO-PCE
3-HO-PCP
3-HO-PCE

Well that being said i find this Memantine to be incredibly unique and enjoyable, functional. The dosages i use to get loose so far have been 80-100mgs. It has this incredible euphoria for me that has me absolutely glowing all day and it makes me so happy. It has this sorta 4K like visual effects that makes everything look so fluid and beautiful. Personally i dont get traditional Dissos visuals as in the OEV/CEV type but its more like the entire world is changed into this hyper realistic clarity and seems to have more depth.

The duration is also fantastic IMO because i can dose it in the morning and be fully there for the entire day and still even feel effects the day after. It takes forever to kick in, but once your there its straight bliss and i can even function at my job fine or out and about with my girlfriend. Ive had alot of success using it in combo with GHB as well and when i do both at the same time it puts me straight into god mode and the sex me and my girl have is completely mindblowing.

Well i just wanted to put out my findings after using this stuff for awhile. My usual dosage is 20mgs a day but every once in awhile i like to do a bigger one like i mentioned just as a little treat, plan on doing a combo this month of n2O, Memantine and GHB and im expecting that to be wonderful. Hope somebody out there finds this post useful, this is certainly a versatile compound and a welcome addition to the stash.
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This is really something. I’m looking for something for severe anxiety. I take Percocet for now, but the bliss from that is gone. It only works for pain now and I’m left feeling lost, down and filled with anxiety.
Your thoughts? And do I need a prescription for that stuff?
Love and thanks
 
It depends on where you want to buy the memantine. In most countries you will need a prescription but chances are you can get one as it is not considered a high abuse drug.
The only indication is Alzheimer's and Parkinson's. In some countries like Italy, Portugal and Mexico you can get it without a prescription.
It works fine against the opioid withdrawal. But my problem was the PAWS after the acute withdrawal.
If anybody can give me a advice to overhelm that I would be very thanksful. I tried it with sports, wellness and microdose Iboga. But it was finaly not strong enaught...
 
Dr.Faust said:
It depends on where you want to buy the memantine. In most countries you will need a prescription but chances are you can get one as it is not considered a high abuse drug.
The only indication is Alzheimer's and Parkinson's. In some countries like Italy, Portugal and Mexico you can get it without a prescription.
It works fine against the opioid withdrawal. But my problem was the PAWS after the acute withdrawal.
If anybody can give me a advice to overhelm that I would be very thanksful. I tried it with sports, wellness and microdose Iboga. But it was finaly not strong enaught...
Click to expand...
Maybe you could persevere with the memantine, then try exercise, healthy eating, you could try SSRI/SNRIs, low dose ketamine (infrequently but it's supposed to be good for depression), or pyshedelics like psilocybin or LSD either micro dosed frequently or taken occasionally in higher doses.
There's a lot of ways of treating depression. Or alternatively you can go on low dose bupe (preferably) or, last resort, methadone and sloooowly taper that, then use the memantine when you're ready to jump off.
 
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