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N&PD Moderators: Skorpio | thegreenhand
I Like to Draw Pictures of Random Molecules
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Gaffy
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I'm in class now but I'll try to explain my thinking when I'll get home.
EDIT: It's basically a wild-guess structure-Wise.
If you look at the structure of the L-THP derivates, you'll notice their structure incorporates either M?thylph?nidate or BK-Methamphetamine, and disso-like structure, and that's when I thought they might be active at Sigma receptors. Now look at Siramesine and at 4-PPBP, they both slighlty ressemble the core structure of cannabino?ds. Now back to the L-THP, and overlay it with THC; it matches, so "mixing" them should work.. Then take a look at PRE-084, and adapt it to the carbomethoxy on the one which ressembles MPH. If you follow that logic of overlaying bit by bit, at least that's what I did, you end up with Indeed quite a bulky chem but it seems to match the logic. I made some new ones with explaining:
If you look at the structure of the L-THP derivates, you'll notice their structure incorporates either M?thylph?nidate or BK-Methamphetamine, and disso-like structure, and that's when I thought they might be active at Sigma receptors. Now look at Siramesine and at 4-PPBP, they both slighlty ressemble the core structure of cannabino?ds. Now back to the L-THP, and overlay it with THC; it matches, so "mixing" them should work.. Then take a look at PRE-084, and adapt it to the carbomethoxy on the one which ressembles MPH. If you follow that logic of overlaying bit by bit, at least that's what I did, you end up with Indeed quite a bulky chem but it seems to match the logic. I made some new ones with explaining:
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sekio
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As far as I know, the sigma receptor is pretty promiscuous in its binding, lots of stuff with varying structures have activity. Pregnenolone (steroid), ketamine, methamphetamine, racemethorphan, noscapine, DMT, (es)citalopram, cocaine, etc all have affinity and they have very diverse structures.
Some of those structures remind me of compounds with known hERG blocking activity however, which is Not A Good Thing.
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So apparently phenylalanol carbamate is orally active as a NDRI? Do we know anything about the SAR? How about aminotryptophol carbamate? O-methyl aminotyrosol carbamate?
Some of those structures remind me of compounds with known hERG blocking activity however, which is Not A Good Thing.
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So apparently phenylalanol carbamate is orally active as a NDRI? Do we know anything about the SAR? How about aminotryptophol carbamate? O-methyl aminotyrosol carbamate?
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S.J.B.
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Neat... (+)-methamphetamine with a carbamate tacked on. It can be made in one step from D-phenylalaninol, which is fairly cheap, and the composition-of-matter exclusivity for the compound has expired by now in many countries, so it would seem to be a viable target for research-chemical suppliers.
Interestingly, (+)-methamphetamine itself is only three steps from D-phenylalaninol, or two from the also-widely-available N-Boc-D-phenylalaninol. I wonder if anyone has been using either of these as a precursor for large-scale methamphetamine production?
The tyrosine derivative was patented by the same group as the phenylalaninol carbamate, whereas the tryptophan derivative is unknown.
sekio
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That's actually already an article of commerce, it's just N-methyl methyl phenylalanate.
Dresden
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Thanks Dresden, I put it there because p-F fentanyl is said to be longer lasting than regular fent; btw what do you guys think of the Phenidate-L-THP?
And talking of cocaine analogs, how about this:
Or this:
Gaffy,
Those Actually Look Really Impressive To Me.
AMP
S.J.B.
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The D-phenylalanine derivative, which overlays (+)-methamphetamine, has been made, but I can't find any reports testing it for CNS activity.
Gaffy
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Funny how it ressembles ibogaine. recognise the opioid structure, reminds me of dipipanone..
Inspires this: (to me)
Add a Carbomethoxy next to the phenyl+piperidine and you've got a chem quite similar to yours
More alike:
I Wonder if it'll compare to CarFentanyl potency wise
Inspires this: (to me)
Add a Carbomethoxy next to the phenyl+piperidine and you've got a chem quite similar to yours
More alike:
I Wonder if it'll compare to CarFentanyl potency wise
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Soulfake
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Some stuff I randomly drew. The first ones on the left side are molecules I'm thinking about for a few years now, I have a feeling that there could be something good about them or that something similar could be a great substance. If anyone has thoughts about it I would be thankful for input. They are mainly a combination of the structures from Tilidine, Pethidine, Fencamfamine and Phenmetrazine. As those compounds are all very smooth and have nice effects as well as structures that can resemble opioids and stimulants at the same time I think there would be some potential to find something like a light speedball-like opi-stim. (I used "R" as a placeholder for whatever substitution would fit most.)
(//edit: I made a few mistakes; the nitrogen on the first molecule is not on the third unit for the phenethylamine-core (although the current position could make it more similar to a dissociative?) and the two chems below are the same ones, one should have the reverse ester)
The structures on the right side are just some boring -Phenidates and -Morphenates. I wonder if the N-methyl would make them simple pro-drugs to their parent compound? (I don't know why but I like morpholines and norbornanes somehow, similar to others who love benzodioxole units ^^)
On the left down side are just random chems I drew without much thinking.
I really don't know much about chemistry and have only learned (like many others) what I more or less know from looking at different chems, trying RC's and other substances, reading research papers and combine all that, more or less like the early alchemists who didn't really understand what they were doing ^^
//edit: I think this could have potential, HDMP-28 is strong with a short duration, Isopropylphenidate is smooth with a long duration, maybe it would make the HDMP a bit lighter with longer effects. And the methylmorphenate-analogue without isopropyl as it's already weak.
(//edit: I made a few mistakes; the nitrogen on the first molecule is not on the third unit for the phenethylamine-core (although the current position could make it more similar to a dissociative?) and the two chems below are the same ones, one should have the reverse ester)
The structures on the right side are just some boring -Phenidates and -Morphenates. I wonder if the N-methyl would make them simple pro-drugs to their parent compound? (I don't know why but I like morpholines and norbornanes somehow, similar to others who love benzodioxole units ^^)
On the left down side are just random chems I drew without much thinking.
I really don't know much about chemistry and have only learned (like many others) what I more or less know from looking at different chems, trying RC's and other substances, reading research papers and combine all that, more or less like the early alchemists who didn't really understand what they were doing ^^
//edit: I think this could have potential, HDMP-28 is strong with a short duration, Isopropylphenidate is smooth with a long duration, maybe it would make the HDMP a bit lighter with longer effects. And the methylmorphenate-analogue without isopropyl as it's already weak.
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