Jekyl Anhydride
Bluelight Crew
- Joined
- Jul 23, 2016
- Messages
- 5,399
Okay Uncle Scrof quit scaring the kids now. You signed the non disclosure agreement when you left the agency..
linkIn chronic studies, agmatine at a low dose (0.1 mg/kg) which does not affect morphine analgesia acutely prevents tolerance following chronic morphine dosing for 10 days. A higher agmatine dose (10 mg/kg) has a similar effect. Agmatine also blocks tolerance to the δ-opioid receptor ligand [d-Pen2,d-Pen5]enkephalin given intrathecally, but not to the κ3-opioid receptor agonist naloxone benzoylhydrazone. Despite its inactivity on κ1-opioid analgesia in the acute model, agmatine prevents κ1-opioid receptor-mediated tolerance. These studies demonstrate the dramatic interactions between agmatine and opioid analgesia and tolerance.
https://www.ncbi.nlm.nih.gov/pubmed/12852826Recently it has been revealed that some agents that are not able to interact with opioid receptors play an important role in regulating the pharmacological actions of opioids. Especially, some of them show biphasic modulation on opioid functions, which enhance opioid analgesia, but inhibit tolerance to and substance dependence on opioids. We would like to call these agents which do not interact with opioid receptors, but do have biphasic modulation on opioid functions as biphasic opioid function modulator (BOFM). Mainly based on our results, agmatine is a typical BOFM. Agmatine itself was a weak analgesic which enhanced analgesic action of morphine and inhibited tolerance to and dependence on opioid. The main mechanisms of agmatine were related to inhibition of the adaptation of opioid receptor signal transduction induced by chronic treatment of opioid.
https://www.ncbi.nlm.nih.gov/pubmed/17025265Like other monoamine transmitter molecules, agmatine is rapidly metabolized in the periphery and has poor penetration into the brain, which limits the use of agmatine itself as a therapeutic agent. However, the development of agmatinase inhibitors will offer a useful method to increase endogenous agmatine in the brain as a possible therapeutic approach to potentiate morphine analgesia and reduce dependence/withdrawal.
https://www.sciencedirect.com/science/article/pii/S0378874113002481In MOR mRNA expression study, cotreatment of morphine with mitragynine significantly reduced the down-regulation of MOR mRNA expression as compared to morphine treatment only.
These finding suggest that mitragynine could possibly avoid the tolerance and dependence on chronic morphine treatment by reducing the up-regulation of cAMP level as well as reducing the down-regulation of MOR at a lower concentration of mitragynine.
https://www.sciencedirect.com/science/article/pii/S0028390808001305When administered orally, the antinociceptive effect of MGM-9 was seven to 22 times more potent than that of morphine. The antinociceptive effects of MGM-9 were mediated by both μ- and κ-opioid receptors. Subcutaneous administration of MGM-9 twice daily for 5 days led to antinociceptive tolerance. In the gastrointestinal transit study, MGM-9 inhibited gastrointestinal transit, but its effect was weaker than that of morphine at equi-antinociceptive doses. Furthermore, MGM-9 induced less hyperlocomotion and fewer rewarding effects than morphine. The rewarding effect of MGM-9 was blocked by a μ antagonist and enhanced by a κ antagonist. Taken together, the results suggest that MGM-9 is a promising novel analgesic that has a stronger antinociceptive effect and weaker adverse effects than morphine.
I found is link on Agmantine on Reddit but I don't understand it. Anyone wanna translate?
I think it would definitely help w/d as it has a slight glowing effect that accompanies most ndma antagonis. Noticeable potentiation when taking 1gram with 5 grams of kratom. It does not affect duration like GFJ or Tagamet but it definitely seems to increase mood lift/euphoria, similar to 100mgs of dxm without the nasty side effects. From a nootropic perspective it stacks very well with coluracetam and phenylpiracetam.
I think it would definitely help w/d as it has a slight glowing effect that accompanies most ndma antagonis. Noticeable potentiation when taking 1gram with 5 grams of kratom. It does not affect duration like GFJ or Tagamet but it definitely seems to increase mood lift/euphoria, similar to 100mgs of dxm without the nasty side effects. From a nootropic perspective it stacks very well with coluracetam and phenylpiracetam.
mycophile said:So what this guy is saying is just bullshit.
It's annoying when people go around spreading misinformation like this though I don't think he's doing it on purpose because he's not selling Phenylalanine supplements (to the best of my knowledge) so I don't think he has anything to gain there.